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Recurrent Childhood Medulloblastoma

MedGen UID:
137886
•Concept ID:
C0338342
•
Neoplastic Process
Synonyms: Recurrent Pediatric Medulloblastoma; Relapsed Childhood Medulloblastoma; Relapsed Pediatric Medulloblastoma

Definition

The reemergence of childhood medulloblastoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Medulloblastoma

Professional guidelines

PubMed

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Radiotherapy Advances in Paediatric Medulloblastoma Treatment.
Padovani L, Horan G, Ajithkumar T
Clin Oncol (R Coll Radiol) 2019 Mar;31(3):171-181. Epub 2019 Jan 14 doi: 10.1016/j.clon.2019.01.001. PMID: 30655168
Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm.
Coluccia D, Figuereido C, Isik S, Smith C, Rutka JT
Curr Neurol Neurosci Rep 2016 May;16(5):43. doi: 10.1007/s11910-016-0644-7. PMID: 27021772

Recent clinical studies

Etiology

An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.
Adile AA, Bakhshinyan D, Suk Y, Uehling D, Saini M, Aman A, Magolan J, Subapanditha MK, McKenna D, Chokshi C, Savage N, Kameda-Smith MM, Venugopal C, Singh SK
J Neurooncol 2023 Jul;163(3):635-645. Epub 2023 Jun 24 doi: 10.1007/s11060-023-04372-w. PMID: 37354357

Diagnosis

An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.
Adile AA, Bakhshinyan D, Suk Y, Uehling D, Saini M, Aman A, Magolan J, Subapanditha MK, McKenna D, Chokshi C, Savage N, Kameda-Smith MM, Venugopal C, Singh SK
J Neurooncol 2023 Jul;163(3):635-645. Epub 2023 Jun 24 doi: 10.1007/s11060-023-04372-w. PMID: 37354357

Therapy

An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.
Adile AA, Bakhshinyan D, Suk Y, Uehling D, Saini M, Aman A, Magolan J, Subapanditha MK, McKenna D, Chokshi C, Savage N, Kameda-Smith MM, Venugopal C, Singh SK
J Neurooncol 2023 Jul;163(3):635-645. Epub 2023 Jun 24 doi: 10.1007/s11060-023-04372-w. PMID: 37354357
Phase II study of ifosfamide in childhood brain tumors: a report by the French Society of Pediatric Oncology (SFOP).
Chastagner P, Sommelet-Olive D, Kalifa C, Brunat-Mentigny M, Zucker JM, Demeocq F, Baranzelli MC, Tron P, Bergeron C, Pein F
Med Pediatr Oncol 1993;21(1):49-53. doi: 10.1002/mpo.2950210110. PMID: 8381203

Prognosis

Phase II study of ifosfamide in childhood brain tumors: a report by the French Society of Pediatric Oncology (SFOP).
Chastagner P, Sommelet-Olive D, Kalifa C, Brunat-Mentigny M, Zucker JM, Demeocq F, Baranzelli MC, Tron P, Bergeron C, Pein F
Med Pediatr Oncol 1993;21(1):49-53. doi: 10.1002/mpo.2950210110. PMID: 8381203

Clinical prediction guides

Phase II study of ifosfamide in childhood brain tumors: a report by the French Society of Pediatric Oncology (SFOP).
Chastagner P, Sommelet-Olive D, Kalifa C, Brunat-Mentigny M, Zucker JM, Demeocq F, Baranzelli MC, Tron P, Bergeron C, Pein F
Med Pediatr Oncol 1993;21(1):49-53. doi: 10.1002/mpo.2950210110. PMID: 8381203

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