Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Lack of Adrenarche

MedGen UID:: 1378949
•Concept ID:: C4330530
•: Finding

Definition

Absent or incomplete development of adrenal androgen-mediated secondary sexual characteristics. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLack of Adrenarche

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Site or System
    - Reproductive System Finding
      - Lack of Adrenarche

Recent clinical studies

Etiology

Case report: 11-ketotestosterone may potentiate advanced bone age as seen in some cases of Wiedemann-Steiner Syndrome.

Buchanan K, Greenup E, Hurst ACE, Sunil B, Ashraf AP
Front Endocrinol (Lausanne) 2022;13:1004114. Epub 2022 Oct 3 doi: 10.3389/fendo.2022.1004114. PMID: 36263329 Free PMC Article

Relationship between sex hormones, reproductive stages and ADHD: a systematic review.

Camara B, Padoin C, Bolea B
Arch Womens Ment Health 2022 Feb;25(1):1-8. Epub 2021 Sep 6 doi: 10.1007/s00737-021-01181-w. PMID: 34487213

DNA methylation is not involved in specific down-regulation of HSD3B2, NR4A1 and RARB genes in androgen-secreting cells of human adrenal cortex.

Baquedano MS, Perez Garrido N, Goñi J, Saraco N, Aliberti P, Berensztein E, Rivarola MA, Belgorosky A
Mol Cell Endocrinol 2017 Feb 5;441:46-54. Epub 2016 Sep 23 doi: 10.1016/j.mce.2016.09.024. PMID: 27670690

Persistence of delayed adrenarche in boys with thalassemia.

Filosa A, Di Maio S, Esposito G, De Martinis F, De Terlizzi F
J Pediatr Endocrinol Metab 2001 Apr;14(4):407-14. doi: 10.1515/jpem.2001.14.4.407. PMID: 11327374

Premature adrenarche. Clinical and diagnostic features.

Kaplowitz PB, Cockrell JL, Young RB
Clin Pediatr (Phila) 1986 Jan;25(1):28-34. doi: 10.1177/000992288602500105. PMID: 2935348

See all (9)

Diagnosis

A rare occurrence of non-classic congenital adrenal hyperplasia and type 1 diabetes mellitus in a girl with Prader-Willi Syndrome: Case report and review of the literature.

Aureli A, Bocchini S, Mariani M, Crinò A, Cappa M, Fintini D
Front Endocrinol (Lausanne) 2023;14:1148318. Epub 2023 Apr 12 doi: 10.3389/fendo.2023.1148318. PMID: 37124733 Free PMC Article

Case report: 11-ketotestosterone may potentiate advanced bone age as seen in some cases of Wiedemann-Steiner Syndrome.

Buchanan K, Greenup E, Hurst ACE, Sunil B, Ashraf AP
Front Endocrinol (Lausanne) 2022;13:1004114. Epub 2022 Oct 3 doi: 10.3389/fendo.2022.1004114. PMID: 36263329 Free PMC Article

Relationship between sex hormones, reproductive stages and ADHD: a systematic review.

Camara B, Padoin C, Bolea B
Arch Womens Ment Health 2022 Feb;25(1):1-8. Epub 2021 Sep 6 doi: 10.1007/s00737-021-01181-w. PMID: 34487213

Concomitant mutations in the P450 oxidoreductase and androgen receptor genes presenting with 46,XY disordered sex development and androgenization at adrenarche.

Idkowiak J, Malunowicz EM, Dhir V, Reisch N, Szarras-Czapnik M, Holmes DM, Shackleton CH, Davies JD, Hughes IA, Krone N, Arlt W
J Clin Endocrinol Metab 2010 Jul;95(7):3418-27. Epub 2010 Apr 21 doi: 10.1210/jc.2010-0058. PMID: 20410220 Free PMC Article

Premature adrenarche. Clinical and diagnostic features.

Kaplowitz PB, Cockrell JL, Young RB
Clin Pediatr (Phila) 1986 Jan;25(1):28-34. doi: 10.1177/000992288602500105. PMID: 2935348

See all (10)

Therapy

A rare occurrence of non-classic congenital adrenal hyperplasia and type 1 diabetes mellitus in a girl with Prader-Willi Syndrome: Case report and review of the literature.

Aureli A, Bocchini S, Mariani M, Crinò A, Cappa M, Fintini D
Front Endocrinol (Lausanne) 2023;14:1148318. Epub 2023 Apr 12 doi: 10.3389/fendo.2023.1148318. PMID: 37124733 Free PMC Article

Increased adrenal androgen levels in patients with Prader-Willi syndrome are associated with insulin, IGF-I, and leptin, but not with measures of obesity.

L'Allemand D, Eiholzer U, Rousson V, Girard J, Blum W, Torresani T, Gasser T
Horm Res 2002;58(5):215-22. doi: 10.1159/000066263. PMID: 12401940

Persistence of delayed adrenarche in boys with thalassemia.

Filosa A, Di Maio S, Esposito G, De Martinis F, De Terlizzi F
J Pediatr Endocrinol Metab 2001 Apr;14(4):407-14. doi: 10.1515/jpem.2001.14.4.407. PMID: 11327374

Diminished adrenal androgen secretion in familial glucocorticoid deficiency implicates a significant role for ACTH in the induction of adrenarche.

Weber A, Clark AJ, Perry LA, Honour JW, Savage MO
Clin Endocrinol (Oxf) 1997 Apr;46(4):431-7. doi: 10.1046/j.1365-2265.1997.1580969.x. PMID: 9196605

Vaginal bleeding: presenting symptom of acquired primary hypothyroidism in a seven year-old girl.

Rakover Y, Weiner E, Shalev E, Luboshitsky R
J Pediatr Endocrinol 1993 Apr-Jun;6(2):197-200. PMID: 8348225

See all (5)

Prognosis

Pubertal outcome in a female with virilizing adrenocortical carcinoma.

Breidbart E, Cameo T, Garvin JH, Hibshoosh H, Oberfield SE
J Pediatr Endocrinol Metab 2016 Apr;29(4):503-9. doi: 10.1515/jpem-2015-0123. PMID: 26812773 Free PMC Article

See all (1)

Clinical prediction guides

Relationship between sex hormones, reproductive stages and ADHD: a systematic review.

Camara B, Padoin C, Bolea B
Arch Womens Ment Health 2022 Feb;25(1):1-8. Epub 2021 Sep 6 doi: 10.1007/s00737-021-01181-w. PMID: 34487213

DNA methylation is not involved in specific down-regulation of HSD3B2, NR4A1 and RARB genes in androgen-secreting cells of human adrenal cortex.

Persistence of delayed adrenarche in boys with thalassemia.

Filosa A, Di Maio S, Esposito G, De Martinis F, De Terlizzi F
J Pediatr Endocrinol Metab 2001 Apr;14(4):407-14. doi: 10.1515/jpem.2001.14.4.407. PMID: 11327374

Two types of growth hormone rhythm in boys with constitutional short stature.

Keret R, Ashkenazi IE, Wasserman M, Bauman B, Pertzelan A, Ticher A, Laron Z
J Pediatr Endocrinol Metab 1996 Nov-Dec;9(6):599-607. doi: 10.1515/jpem.1996.9.6.599. PMID: 9004175

Premenarcheal endocrine changes in relation to age at menarche.

Apter D, Vihko R
Clin Endocrinol (Oxf) 1985 Jun;22(6):753-60. doi: 10.1111/j.1365-2265.1985.tb00165.x. PMID: 3160508

See all (6)