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Posterior Fossa Neoplasm

MedGen UID:
1379669
•Concept ID:
C2103465
•
Neoplastic Process
Synonyms: Posterior Cranial Fossa Neoplasm; Posterior Cranial Fossa Tumor

Definition

A neoplasm that arises from the posterior cranial fossa. Examples include meningiomas and medulloblastomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPosterior Fossa Neoplasm

Professional guidelines

PubMed

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Differential diagnosis of T2 hyperintense brainstem lesions: Part 2. Diffuse lesions.
Guzmán-De-Villoria JA, Ferreiro-Argüelles C, Fernández-García P
Semin Ultrasound CT MR 2010 Jun;31(3):260-74. doi: 10.1053/j.sult.2010.03.002. PMID: 20483393

Recent clinical studies

Etiology

Case series: acute mood symptoms associated with posterior fossa lesions in children.
Turkel SB, Shu Chen L, Nelson MD, Hyder D, Gilles FH, Woodall L, Braslow K, Tavaré CJ
J Neuropsychiatry Clin Neurosci 2004 Fall;16(4):443-5. doi: 10.1176/jnp.16.4.443. PMID: 15616170

Diagnosis

Rosette-forming glioneuronal tumor: an update.
Anyanwu CT, Robinson TM, Huang JH
Clin Transl Oncol 2020 May;22(5):623-630. Epub 2019 Jul 16 doi: 10.1007/s12094-019-02179-8. PMID: 31313067
Posterior fossa neoplasm and PHACES syndrome: a case report.
Wallen KE, Hadar EJ, Perry V, Bouldin TW, Loehr J, Blatt J
J Pediatr Hematol Oncol 2009 Mar;31(3):203-5. doi: 10.1097/MPH.0b013e3181983b15. PMID: 19262249
Case series: acute mood symptoms associated with posterior fossa lesions in children.
Turkel SB, Shu Chen L, Nelson MD, Hyder D, Gilles FH, Woodall L, Braslow K, Tavaré CJ
J Neuropsychiatry Clin Neurosci 2004 Fall;16(4):443-5. doi: 10.1176/jnp.16.4.443. PMID: 15616170
Primitive neuroectodermal tumor in the cerebellopontine angle with isochromosome 17q presenting as meningioma in a woman 26 years of age.
Izycka-Swieszewska E, Debiec-Rychter M, Kloc W
Clin Neuropathol 2003 Mar-Apr;22(2):66-70. PMID: 12670052
Giant intracranial aneurysm presenting as a posterior fossa mass.
Cohen AR, Aleksic S, Budzilovich GN, Pinto RS, Flamm ES
Surg Neurol 1983 Aug;20(2):160-4. doi: 10.1016/0090-3019(83)90470-6. PMID: 6879414

Prognosis

Rosette-forming glioneuronal tumor: an update.
Anyanwu CT, Robinson TM, Huang JH
Clin Transl Oncol 2020 May;22(5):623-630. Epub 2019 Jul 16 doi: 10.1007/s12094-019-02179-8. PMID: 31313067
Deletion mapping of the medulloblastoma locus on chromosome 17p.
Cogen PH, Daneshvar L, Metzger AK, Edwards MS
Genomics 1990 Oct;8(2):279-85. doi: 10.1016/0888-7543(90)90283-z. PMID: 1979050

Clinical prediction guides

Deletion mapping of the medulloblastoma locus on chromosome 17p.
Cogen PH, Daneshvar L, Metzger AK, Edwards MS
Genomics 1990 Oct;8(2):279-85. doi: 10.1016/0888-7543(90)90283-z. PMID: 1979050

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