U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NTRK2 Gene Rearrangement

MedGen UID:
1380776
Concept ID:
C4330760
Cell or Molecular Dysfunction
Synonyms: Neurotrophic Tyrosine Kinase Receptor 2 Gene Rearrangement; Neurotrophic Tyrosine Kinase Receptor Type 2 Gene Rearrangement; NTRK2 Rearrangement; TRKB Tyrosine Kinase Gene Rearrangement; Tropomyosin-Related Kinase B Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the NTRK2 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNTRK2 Gene Rearrangement

Professional guidelines

PubMed

Bourhis A, Caumont C, Quintin-Roué I, Magro E, Dissaux G, Remoué A, Le Noac'h P, Douet-Guilbert N, Seizeur R, Tyulyandina A, Schick U, Merlio JP, Marcorelles P, Cappellen D, Uguen A
Pathology 2022 Feb;54(1):55-62. Epub 2021 Sep 10 doi: 10.1016/j.pathol.2021.05.100. PMID: 34518039

Recent clinical studies

Etiology

Zhao R, Yao F, Xiang C, Zhao J, Shang Z, Guo L, Ding W, Ma S, Yu A, Shao J, Zhu L, Han Y
J Pathol Clin Res 2021 Jul;7(4):375-384. Epub 2021 Mar 26 doi: 10.1002/cjp2.208. PMID: 33768710Free PMC Article
Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C
Acta Neuropathol Commun 2020 Nov 5;8(1):182. doi: 10.1186/s40478-020-01054-w. PMID: 33153497Free PMC Article
Leal JL, Peters G, Szaumkessel M, Leong T, Asadi K, Rivalland G, Do H, Senko C, Mitchell PL, Quing CZ, Dobrovic A, Thapa B, John T
Lung Cancer 2020 Aug;146:154-159. Epub 2020 May 24 doi: 10.1016/j.lungcan.2020.05.019. PMID: 32540558
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators
Lancet Oncol 2020 Feb;21(2):271-282. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30691-6. PMID: 31838007Free PMC Article
Nobusawa S, Hirato J, Yokoo H
Brain Tumor Pathol 2014 Oct;31(4):229-33. Epub 2014 Sep 3 doi: 10.1007/s10014-014-0200-6. PMID: 25182241

Diagnosis

Wu S, Liu Y, Li K, Liang Z, Zeng X
J Mol Diagn 2023 Aug;25(8):569-582. Epub 2023 May 25 doi: 10.1016/j.jmoldx.2023.04.007. PMID: 37236546
Hondelink LM, Schrader AMR, Asri Aghmuni G, Solleveld-Westerink N, Cleton-Jansen AM, van Egmond D, Boot A, Ouahoud S, Khalifa MN, Wai Lam S, Morreau H, Bovee JVMG, van Wezel T, Cohen D
Eur J Cancer 2022 Sep;173:229-237. Epub 2022 Aug 4 doi: 10.1016/j.ejca.2022.06.030. PMID: 35933886
Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C
Acta Neuropathol Commun 2020 Nov 5;8(1):182. doi: 10.1186/s40478-020-01054-w. PMID: 33153497Free PMC Article
Solomon JP, Hechtman JF
Cancer Res 2019 Jul 1;79(13):3163-3168. Epub 2019 Jun 13 doi: 10.1158/0008-5472.CAN-19-0372. PMID: 31196931Free PMC Article
Rudzinski ER, Lockwood CM, Stohr BA, Vargas SO, Sheridan R, Black JO, Rajaram V, Laetsch TW, Davis JL
Am J Surg Pathol 2018 Jul;42(7):927-935. doi: 10.1097/PAS.0000000000001062. PMID: 29683818

Therapy

Gao L, Ai X, Lu S
Lung Cancer 2024 Jan;187:107443. Epub 2023 Dec 15 doi: 10.1016/j.lungcan.2023.107443. PMID: 38113652
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators
Lancet Oncol 2020 Feb;21(2):271-282. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30691-6. PMID: 31838007Free PMC Article

Prognosis

Mosaieby E, Martínek P, Ondič O
Mol Genet Genomic Med 2022 Aug;10(8):e1994. Epub 2022 May 27 doi: 10.1002/mgg3.1994. PMID: 35621010Free PMC Article
Bourhis A, Caumont C, Quintin-Roué I, Magro E, Dissaux G, Remoué A, Le Noac'h P, Douet-Guilbert N, Seizeur R, Tyulyandina A, Schick U, Merlio JP, Marcorelles P, Cappellen D, Uguen A
Pathology 2022 Feb;54(1):55-62. Epub 2021 Sep 10 doi: 10.1016/j.pathol.2021.05.100. PMID: 34518039
Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C
Acta Neuropathol Commun 2020 Nov 5;8(1):182. doi: 10.1186/s40478-020-01054-w. PMID: 33153497Free PMC Article
Rudzinski ER, Lockwood CM, Stohr BA, Vargas SO, Sheridan R, Black JO, Rajaram V, Laetsch TW, Davis JL
Am J Surg Pathol 2018 Jul;42(7):927-935. doi: 10.1097/PAS.0000000000001062. PMID: 29683818
Murphy DA, Ely HA, Shoemaker R, Boomer A, Culver BP, Hoskins I, Haimes JD, Walters RD, Fernandez D, Stahl JA, Lee J, Kim KM, Lamoureux J, Christiansen J
Appl Immunohistochem Mol Morphol 2017 Aug;25(7):513-523. doi: 10.1097/PAI.0000000000000360. PMID: 27028240Free PMC Article

Clinical prediction guides

Mosaieby E, Martínek P, Ondič O
Mol Genet Genomic Med 2022 Aug;10(8):e1994. Epub 2022 May 27 doi: 10.1002/mgg3.1994. PMID: 35621010Free PMC Article
Bourhis A, Caumont C, Quintin-Roué I, Magro E, Dissaux G, Remoué A, Le Noac'h P, Douet-Guilbert N, Seizeur R, Tyulyandina A, Schick U, Merlio JP, Marcorelles P, Cappellen D, Uguen A
Pathology 2022 Feb;54(1):55-62. Epub 2021 Sep 10 doi: 10.1016/j.pathol.2021.05.100. PMID: 34518039
Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C
Acta Neuropathol Commun 2020 Nov 5;8(1):182. doi: 10.1186/s40478-020-01054-w. PMID: 33153497Free PMC Article
Rudzinski ER, Lockwood CM, Stohr BA, Vargas SO, Sheridan R, Black JO, Rajaram V, Laetsch TW, Davis JL
Am J Surg Pathol 2018 Jul;42(7):927-935. doi: 10.1097/PAS.0000000000001062. PMID: 29683818
Nobusawa S, Hirato J, Yokoo H
Brain Tumor Pathol 2014 Oct;31(4):229-33. Epub 2014 Sep 3 doi: 10.1007/s10014-014-0200-6. PMID: 25182241

Recent systematic reviews

Suurmeijer AJH, Dickson BC, Swanson D, Zhang L, Sung YS, Cotzia P, Fletcher CDM, Antonescu CR
Genes Chromosomes Cancer 2018 Dec;57(12):611-621. Epub 2018 Oct 1 doi: 10.1002/gcc.22671. PMID: 30276917Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...