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Hypodipsia

MedGen UID:
1382654
•Concept ID:
C0919912
•
Finding
HPO: HP:0025382

Definition

Reduced fluid intake (drinking) in a clinical situation where the plasma molarity or sodium concentration normally would induce greater fluid intake. [from HPO]

Professional guidelines

PubMed

Morbidity and mortality associated with vasopressin analogue treatment.
Toumba M, Stanhope R
J Pediatr Endocrinol Metab 2006 Mar;19(3):197-201. doi: 10.1515/jpem.2006.19.3.197. PMID: 16607917
The management of diabetes mellitus in older individuals.
Morley JE, Perry HM 3rd
Drugs 1991 Apr;41(4):548-65. doi: 10.2165/00003495-199141040-00004. PMID: 1711959
Hypernatremia due to hypodipsia and elevated threshold for vasopressin release. Effects of treatment with hydrochlorothiazide, chlorpropamide and tolbutamide.
Mahoney JH, Goodman AD
N Engl J Med 1968 Nov 28;279(22):1191-6. doi: 10.1056/NEJM196811282792203. PMID: 4301177

Recent clinical studies

Etiology

Quench the thirst: lessons from clinical thirst trials.
Arai SR, Butzlaff A, Stotts NA, Puntillo KA
Biol Res Nurs 2014 Oct;16(4):456-66. Epub 2013 Oct 16 doi: 10.1177/1099800413505900. PMID: 24136996Free PMC Article
Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes.
Stamelou M, Christ H, Reuss A, Oertel W, Höglinger G
Mov Disord 2011 Apr;26(5):901-5. Epub 2011 Mar 7 doi: 10.1002/mds.23587. PMID: 21384428
The management of diabetes mellitus in older individuals.
Morley JE, Perry HM 3rd
Drugs 1991 Apr;41(4):548-65. doi: 10.2165/00003495-199141040-00004. PMID: 1711959
Aging and risks for dehydration.
Silver AJ
Cleve Clin J Med 1990 Jun;57(4):341-4. doi: 10.3949/ccjm.57.4.341. PMID: 2194700
Hypodipsia in geriatric patients.
Miller PD, Krebs RA, Neal BJ, McIntyre DO
Am J Med 1982 Sep;73(3):354-6. doi: 10.1016/0002-9343(82)90726-4. PMID: 7124762

Diagnosis

Hypodipsic-hypernatremia syndrome in an adult with polycythemia: a case report.
Chothia MY, George K, Sheik M, Davids MR
J Med Case Rep 2018 Dec 27;12(1):381. doi: 10.1186/s13256-018-1938-y. PMID: 30587223Free PMC Article
ROHHAD in a 9-year-old boy — clinical case.
Kot K, Moszczyńska E, Lecka-Ambroziak A, Migdał M, Szalecki M
Endokrynol Pol 2016;67(2):226-31. doi: 10.5603/EP.a2016.0037. PMID: 26884306
Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes.
Stamelou M, Christ H, Reuss A, Oertel W, Höglinger G
Mov Disord 2011 Apr;26(5):901-5. Epub 2011 Mar 7 doi: 10.1002/mds.23587. PMID: 21384428
Glycerol kinase deficiency presenting with hypodipsia, osmotic diuresis and severe hypernatraemia.
Mak TW, Wong LM, Wong SN, Tse K, Lai JP
J Inherit Metab Dis 2005;28(6):1159-61. doi: 10.1007/s10545-005-0101-2. PMID: 16435217
The hypodipsia-hypernatraemia syndrome presenting with obesity.
Powell D, Codd M, Skrabanek P, Tempany E
Ir J Med Sci 1983 Sep;152(9):357-9. doi: 10.1007/BF02954735. PMID: 6642963

Therapy

Quench the thirst: lessons from clinical thirst trials.
Arai SR, Butzlaff A, Stotts NA, Puntillo KA
Biol Res Nurs 2014 Oct;16(4):456-66. Epub 2013 Oct 16 doi: 10.1177/1099800413505900. PMID: 24136996Free PMC Article
Morbidity and mortality associated with vasopressin analogue treatment.
Toumba M, Stanhope R
J Pediatr Endocrinol Metab 2006 Mar;19(3):197-201. doi: 10.1515/jpem.2006.19.3.197. PMID: 16607917
The management of diabetes mellitus in older individuals.
Morley JE, Perry HM 3rd
Drugs 1991 Apr;41(4):548-65. doi: 10.2165/00003495-199141040-00004. PMID: 1711959
Hypodipsia-hypernatremia syndrome.
Schaad U, Vassella F, Zuppinger K, Oetliker O
Helv Paediatr Acta 1979 Feb;34(1):63-76. PMID: 429194
Syndrome of hypernatremia, hypodipsia and partial diabetes insipidus: a new interpretation.
Sridhar CB, Calvert GD, Ibbertson HK
J Clin Endocrinol Metab 1974 May;38(5):890-901. doi: 10.1210/jcem-38-5-890. PMID: 4823926

Prognosis

Extreme hypernatraemia: a case report and brief review.
Holley AD, Green S, Davoren P
Crit Care Resusc 2007 Mar;9(1):55-8. PMID: 17352668
Hypothalamic dysfunction in a child: a distinct syndrome? Report of a case and review of the literature.
Proulx F, Weber ML, Collu R, Lelièvre M, Larbrisseau A, Delisle M
Eur J Pediatr 1993 Jun;152(6):526-9. doi: 10.1007/BF01955066. PMID: 7687546

Clinical prediction guides

Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes.
Stamelou M, Christ H, Reuss A, Oertel W, Höglinger G
Mov Disord 2011 Apr;26(5):901-5. Epub 2011 Mar 7 doi: 10.1002/mds.23587. PMID: 21384428
Salt-losing nephropathy associated with inappropriate secretion of atrial natriuretic peptide--a new clinical syndrome.
Rodríguez-Soriano J, Vallo A
Pediatr Nephrol 1997 Oct;11(5):565-72. doi: 10.1007/s004670050339. PMID: 9323281
Recurrent hypothermia, hypersomnolence, central sleep apnea, hypodipsia, hypernatremia, hypothyroidism, hyperprolactinemia and growth hormone deficiency in a boy--treatment with clomipramine.
Gurewitz R, Blum I, Lavie P, Pertzelan A, Stivel M, Weinstein R, Galatzer A, Laron Z
Acta Endocrinol Suppl (Copenh) 1986;279:468-72. doi: 10.1530/acta.0.112s468. PMID: 3465179
Transient diabetes insipidus with elevated serum osmolarity associated with 'benign' febrile illness.
Dorfman SG, Ruark GW, Agus ZS, Jacobs RL, Young RL
Arch Intern Med 1977 Oct;137(10):1479-81. PMID: 921428

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