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Obesity-Associated Insulin Resistance

MedGen UID:
1383912
•Concept ID:
C4331921
•
Disease or Syndrome

Definition

Insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObesity-Associated Insulin Resistance

Professional guidelines

PubMed

The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.
Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips BR, Mauger DT, Wenzel SE, Fajt ML, Koliwad SK, Denlinger LC, Woodruff PG, Jarjour NN, Fahy JV; National Heart, Lung, and Blood Institute Severe Asthma Research Program-3
Am J Respir Crit Care Med 2022 Nov 1;206(9):1096-1106. doi: 10.1164/rccm.202112-2745OC. PMID: 35687105Free PMC Article
The evaluation and management of childhood type 2 diabetes mellitus.
Scollan-Koliopoulos M, David B
Prim Care Diabetes 2011 Oct;5(3):151-8. Epub 2011 May 26 doi: 10.1016/j.pcd.2011.04.002. PMID: 21616738
Pathogenesis, risk assessment and prevention of type 2 diabetes mellitus.
Joost HG
Obes Facts 2008;1(3):128-37. Epub 2008 Jun 20 doi: 10.1159/000137673. PMID: 20054172Free PMC Article

Recent clinical studies

Etiology

Adipose tissue and insulin resistance in obese.
Ahmed B, Sultana R, Greene MW
Biomed Pharmacother 2021 May;137:111315. Epub 2021 Feb 6 doi: 10.1016/j.biopha.2021.111315. PMID: 33561645
Mechanistic Links between Obesity, Insulin, and Cancer.
Perry RJ, Shulman GI
Trends Cancer 2020 Feb;6(2):75-78. Epub 2020 Jan 14 doi: 10.1016/j.trecan.2019.12.003. PMID: 32061306Free PMC Article
Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
Al-Sulaiti H, Diboun I, Agha MV, Mohamed FFS, Atkin S, Dömling AS, Elrayess MA, Mazloum NA
J Transl Med 2019 Oct 22;17(1):348. doi: 10.1186/s12967-019-2096-8. PMID: 31640727Free PMC Article
Obesity, insulin resistance and free fatty acids.
Boden G
Curr Opin Endocrinol Diabetes Obes 2011 Apr;18(2):139-43. doi: 10.1097/MED.0b013e3283444b09. PMID: 21297467Free PMC Article
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP
Cell Metab 2009 Apr;9(4):311-26. doi: 10.1016/j.cmet.2009.02.002. PMID: 19356713Free PMC Article

Diagnosis

Does obesity-associated insulin resistance affect brain structure and function of adolescents differentially by sex?
Gabay A, London S, Yates KF, Convit A
Psychiatry Res Neuroimaging 2022 Jan;319:111417. Epub 2021 Nov 24 doi: 10.1016/j.pscychresns.2021.111417. PMID: 34875560Free PMC Article
Adipose tissue and insulin resistance in obese.
Ahmed B, Sultana R, Greene MW
Biomed Pharmacother 2021 May;137:111315. Epub 2021 Feb 6 doi: 10.1016/j.biopha.2021.111315. PMID: 33561645
Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
Al-Sulaiti H, Diboun I, Agha MV, Mohamed FFS, Atkin S, Dömling AS, Elrayess MA, Mazloum NA
J Transl Med 2019 Oct 22;17(1):348. doi: 10.1186/s12967-019-2096-8. PMID: 31640727Free PMC Article
Adipose extracellular matrix remodelling in obesity and insulin resistance.
Lin D, Chun TH, Kang L
Biochem Pharmacol 2016 Nov 1;119:8-16. Epub 2016 May 12 doi: 10.1016/j.bcp.2016.05.005. PMID: 27179976Free PMC Article
Insulin resistance and insulin sensitizers.
Stumvoll M, Häring H
Horm Res 2001;55 Suppl 2:3-13. doi: 10.1159/000063466. PMID: 11684868

Therapy

Adipocyte subpopulations mediate lipolysis and obesity-induced insulin resistance.
Huang J, Sharma R, Siyar S, Sharma V, Puri V, Lee KY
J Endocrinol 2024 Mar 1;260(3) Epub 2024 Jan 22 doi: 10.1530/JOE-23-0149. PMID: 38174979
Effect of acute TLR4 inhibition on insulin resistance in humans.
Liang H, Sathavarodom N, Colmenares C, Gelfond J, Espinoza SE, Ganapathy V, Musi N
J Clin Invest 2022 Nov 1;132(21) doi: 10.1172/JCI162291. PMID: 36066991Free PMC Article
Hypothalamic inflammation in obesity and metabolic disease.
Jais A, Brüning JC
J Clin Invest 2017 Jan 3;127(1):24-32. doi: 10.1172/JCI88878. PMID: 28045396Free PMC Article
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP
Cell Metab 2009 Apr;9(4):311-26. doi: 10.1016/j.cmet.2009.02.002. PMID: 19356713Free PMC Article
Insulin resistance and insulin sensitizers.
Stumvoll M, Häring H
Horm Res 2001;55 Suppl 2:3-13. doi: 10.1159/000063466. PMID: 11684868

Prognosis

Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity.
Jachthuber Trub C, Balikcioglu M, Freemark M, Bain J, Muehlbauer M, Ilkayeva O, White PJ, Armstrong S, Østbye T, Grambow S, Gumus Balikcioglu P
Endocrinol Diabetes Metab 2021 Jul;4(3):e00250. Epub 2021 Apr 1 doi: 10.1002/edm2.250. PMID: 34277974Free PMC Article
Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes.
Dahik VD, Frisdal E, Le Goff W
Int J Mol Sci 2020 Jul 31;21(15) doi: 10.3390/ijms21155505. PMID: 32752107Free PMC Article
Mechanistic Links between Obesity, Insulin, and Cancer.
Perry RJ, Shulman GI
Trends Cancer 2020 Feb;6(2):75-78. Epub 2020 Jan 14 doi: 10.1016/j.trecan.2019.12.003. PMID: 32061306Free PMC Article
Immunopathology of Adipose Tissue during Metabolic Syndrome.
Ghazarian M, Luck H, Revelo XS, Winer S, Winer DA
Turk Patoloji Derg 2015;31 Suppl 1:172-80. doi: 10.5146/tjpath.2015.01323. PMID: 26177326
The evaluation and management of childhood type 2 diabetes mellitus.
Scollan-Koliopoulos M, David B
Prim Care Diabetes 2011 Oct;5(3):151-8. Epub 2011 May 26 doi: 10.1016/j.pcd.2011.04.002. PMID: 21616738

Clinical prediction guides

CD8(+) Treg cells play a role in the obesity-associated insulin resistance.
Barbosa P, Pinho A, Lázaro A, Rosendo-Silva D, Paula D, Campos J, Tralhão JG, Pereira MJ, Paiva A, Laranjeira P, Carvalho E
Life Sci 2024 Jan 1;336:122306. Epub 2023 Nov 27 doi: 10.1016/j.lfs.2023.122306. PMID: 38030055
Does obesity-associated insulin resistance affect brain structure and function of adolescents differentially by sex?
Gabay A, London S, Yates KF, Convit A
Psychiatry Res Neuroimaging 2022 Jan;319:111417. Epub 2021 Nov 24 doi: 10.1016/j.pscychresns.2021.111417. PMID: 34875560Free PMC Article
Adipose extracellular matrix remodelling in obesity and insulin resistance.
Lin D, Chun TH, Kang L
Biochem Pharmacol 2016 Nov 1;119:8-16. Epub 2016 May 12 doi: 10.1016/j.bcp.2016.05.005. PMID: 27179976Free PMC Article
Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity.
Eckardt K, Taube A, Eckel J
Rev Endocr Metab Disord 2011 Sep;12(3):163-72. doi: 10.1007/s11154-011-9168-2. PMID: 21336841
Insulin resistance and insulin sensitizers.
Stumvoll M, Häring H
Horm Res 2001;55 Suppl 2:3-13. doi: 10.1159/000063466. PMID: 11684868

Recent systematic reviews

Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes.
De Spiegeleer M, De Paepe E, Van Meulebroek L, Gies I, De Schepper J, Vanhaecke L
Mol Med 2021 Nov 6;27(1):145. doi: 10.1186/s10020-021-00394-0. PMID: 34742239Free PMC Article
Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review.
Himbert C, Thompson H, Ulrich CM
Obes Facts 2017;10(6):648-665. Epub 2017 Dec 14 doi: 10.1159/000479972. PMID: 29237161Free PMC Article

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