U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal vestibular saccule morphology

MedGen UID:
1384115
•Concept ID:
C4476902
•
Anatomical Abnormality
HPO: HP:0030999

Definition

Any structural anomaly of the saccule of the vestibule. The saccule is the otolith organ that senses motions in the sagittal plane (i.e., up-down movement). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal vestibular saccule morphology

Recent clinical studies

Etiology

Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Peripheral vestibular pathology in Mondini dysplasia.
Kaya S, Hızlı Ö, Kaya FK, Monsanto RD, Paparella MM, Cureoglu S
Laryngoscope 2017 Jan;127(1):206-209. Epub 2016 Apr 14 doi: 10.1002/lary.25995. PMID: 27075694
Interaural difference values of vestibular evoked myogenic.
Moallemi M, Hajiabolhassan F, Fatahi J, Abolfazli R, Jalaei S, Khamseh F
Acta Med Iran 2015;53(1):33-8. PMID: 25597603
Peripheral vestibular system in Down syndrome: quantitative assessment of vestibular histopathology.
Inagaki T, Morita N, Cureoglu S, Schachern PA, Nomiya S, Nomiya R, Paparella MM
Otolaryngol Head Neck Surg 2011 Feb;144(2):280-3. doi: 10.1177/0194599810391204. PMID: 21493431
Vestibular evoked myogenic potential latencies in Meniere disease and vestibular schwannoma.
Beyea JA, Zeitouni AG
J Otolaryngol Head Neck Surg 2010 Jun;39(3):253-8. PMID: 20470669

Diagnosis

Clinical features of otolith organ-specific vestibular dysfunction.
Fujimoto C, Suzuki S, Kinoshita M, Egami N, Sugasawa K, Iwasaki S
Clin Neurophysiol 2018 Jan;129(1):238-245. Epub 2017 Nov 21 doi: 10.1016/j.clinph.2017.11.006. PMID: 29207275
Interaural difference values of vestibular evoked myogenic.
Moallemi M, Hajiabolhassan F, Fatahi J, Abolfazli R, Jalaei S, Khamseh F
Acta Med Iran 2015;53(1):33-8. PMID: 25597603
Vestibular evoked myogenic potential latencies in Meniere disease and vestibular schwannoma.
Beyea JA, Zeitouni AG
J Otolaryngol Head Neck Surg 2010 Jun;39(3):253-8. PMID: 20470669
Evolutionary changes in the cochlea and labyrinth: Solving the problem of sound transmission to the balance organs of the inner ear.
Carey J, Amin N
Anat Rec A Discov Mol Cell Evol Biol 2006 Apr;288(4):482-9. doi: 10.1002/ar.a.20306. PMID: 16552774
Vestibulo-ocular physiology underlying vestibular hypofunction.
Schubert MC, Minor LB
Phys Ther 2004 Apr;84(4):373-85. PMID: 15049730

Therapy

Head-shaking aids in the diagnosis of acute audiovestibular loss due to anterior inferior cerebellar artery infarction.
Huh YE, Koo JW, Lee H, Kim JS
Audiol Neurootol 2013;18(2):114-24. Epub 2012 Dec 28 doi: 10.1159/000345643. PMID: 23296146
Vestibular evoked myogenic potentials in acute acoustic trauma.
Wang YP, Hsu WC, Young YH
Otol Neurotol 2006 Oct;27(7):956-61. doi: 10.1097/01.mao.0000231590.57348.4b. PMID: 17006346
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility.
Peterka RJ
Acta Astronaut 1994 Jul;33:1-8. doi: 10.1016/0094-5765(94)90101-5. PMID: 11539508
Vaterite otoconia in two cases of otoconial membrane dysplasia.
Wright CG, Rouse RC, Johnsson LG, Weinberg AG, Hubbard DG
Ann Otol Rhinol Laryngol 1982 Mar-Apr;91(2 Pt 1):193-9. doi: 10.1177/000348948209100215. PMID: 6123288
Experimental pathogenesis of hydrops.
Kimura RS
Arch Otorhinolaryngol 1976 Sep 16;212(4):263-75. doi: 10.1007/BF00453674. PMID: 990078

Prognosis

Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Why do patients with PSP fall? Evidence for abnormal otolith responses.
Liao K, Wagner J, Joshi A, Estrovich I, Walker MF, Strupp M, Leigh RJ
Neurology 2008 Mar 4;70(10):802-9. Epub 2008 Jan 16 doi: 10.1212/01.wnl.0000304134.33380.1e. PMID: 18199830
Vestibular evoked myogenic potentials in acute acoustic trauma.
Wang YP, Hsu WC, Young YH
Otol Neurotol 2006 Oct;27(7):956-61. doi: 10.1097/01.mao.0000231590.57348.4b. PMID: 17006346
Vestibulo-ocular physiology underlying vestibular hypofunction.
Schubert MC, Minor LB
Phys Ther 2004 Apr;84(4):373-85. PMID: 15049730
Cogan's syndrome: clinical significance of antibodies against the inner ear and cornea.
Helmchen C, Arbusow V, Jäger L, Strupp M, Stöcker W, Schulz P
Acta Otolaryngol 1999;119(5):528-36. doi: 10.1080/00016489950180748. PMID: 10478591

Clinical prediction guides

The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans.
Maroto AF, Borrajo M, Prades S, Callejo À, Amilibia E, Pérez-Grau M, Roca-Ribas F, Castellanos E, Barrallo-Gimeno A, Llorens J
Arch Toxicol 2023 Jul;97(7):1943-1961. Epub 2023 May 17 doi: 10.1007/s00204-023-03518-z. PMID: 37195449Free PMC Article
Retro-labyrinthine Lesion Site Detected by Galvanic Vestibular Stimulation Elicited Vestibular-evoked Myogenic Potentials in Patients with Auditory Neuropathy.
Chen ZC, Zhang YZ, Zhao HD, Wei X, Murofushi T, Hu J, Cheng Y, Chen FY, Xu XD, Xu M, Zhang Q
Curr Med Sci 2021 Aug;41(4):695-704. Epub 2021 Aug 17 doi: 10.1007/s11596-021-2411-5. PMID: 34403094
Different findings of morphological changes and functional decline in the vestibule and the semicircular canal in ipsilateral delayed endolymphatic hydrops.
Yu J, Zhou YJ, Xu XD, Tian L, Ren DD, Ding CR, Wang J, Chi FL
Clin Neurophysiol 2020 Jul;131(7):1487-1494. Epub 2020 Apr 23 doi: 10.1016/j.clinph.2020.03.032. PMID: 32388473
Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Streptidine, a metabolic derivative produced after administration of streptomycin in vivo, is vestibulotoxic in rats.
Granados O, Meza G
Histol Histopathol 2005 Apr;20(2):357-64. doi: 10.14670/HH-20.357. PMID: 15736038

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...