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Factor XII Inactivation

MedGen UID:
1384135
•Concept ID:
C4329972
•
Disease or Syndrome

Definition

Presence of inactivating antibodies to factor XII in the blood. [from NCI]

Professional guidelines

PubMed

Thromboelastography used to assess coagulation during treatment with molecular adsorbent recirculating system.
Doria C, Mandalà L, Smith JD, Caruana G, Scott VL, Gruttadauria S, Magnone M, Marino IR
Clin Transplant 2004 Aug;18(4):365-71. doi: 10.1111/j.1399-0012.2004.00172.x. PMID: 15233811

Recent clinical studies

Etiology

New insights into hereditary angio-oedema: Molecular diagnosis and therapy.
Nagy N, Grattan CE, McGrath JA
Australas J Dermatol 2010 Aug;51(3):157-62. doi: 10.1111/j.1440-0960.2010.00649.x. PMID: 20695852
Pathogenesis of malignant pleural mesothelioma.
Jaurand MC, Fleury-Feith J
Respirology 2005 Jan;10(1):2-8. doi: 10.1111/j.1440-1843.2005.00694.x. PMID: 15691231
Measurement of activated factor XII in health and disease.
Coppola R, Cristilli P, Cugno M, Ariëns RA, Mari D, Mannucci PM
Blood Coagul Fibrinolysis 1996 Jul;7(5):530-5. doi: 10.1097/00001721-199607000-00004. PMID: 8874863
Heparin and its derivatives modulate serine proteinases (SERPS) serine proteinase inhibitors (SERPINS) balance. Physiopathological relevance.
Hornebeck W, Lafuma C, Robert L, Móczár M, Móczár E
Pathol Res Pract 1994 Oct;190(9-10):895-902. doi: 10.1016/S0344-0338(11)80993-3. PMID: 7899138
Relationship between factor XII, von Willebrand factor and postoperative deep vein thrombosis.
Nilsson T, Mellbring G, Hedner U
Acta Chir Scand 1986 May;152:347-9. PMID: 3090810

Diagnosis

Hereditary and acquired angioedema.
Patel G, Pongracic JA
Allergy Asthma Proc 2019 Nov 1;40(6):441-445. doi: 10.2500/aap.2019.40.4267. PMID: 31690390
Hereditary angioedema with normal C1-INH (HAE type III).
Riedl MA
J Allergy Clin Immunol Pract 2013 Sep-Oct;1(5):427-32. Epub 2013 Aug 2 doi: 10.1016/j.jaip.2013.06.004. PMID: 24565612
Pathophysiology of hereditary angioedema.
Zuraw BL, Christiansen SC
Am J Rhinol Allergy 2011 Nov-Dec;25(6):373-8. doi: 10.2500/ajra.2011.25.3661. PMID: 22185738
Hereditary angioedema.
Bracho FA
Curr Opin Hematol 2005 Nov;12(6):493-8. doi: 10.1097/01.moo.0000179805.57486.4e. PMID: 16217168
Pathogenesis of malignant pleural mesothelioma.
Jaurand MC, Fleury-Feith J
Respirology 2005 Jan;10(1):2-8. doi: 10.1111/j.1440-1843.2005.00694.x. PMID: 15691231

Therapy

Bradykinin-mediated diseases.
Kaplan AP
Chem Immunol Allergy 2014;100:140-7. Epub 2014 May 22 doi: 10.1159/000358619. PMID: 24925394
Pathophysiology of hereditary angioedema.
Zuraw BL, Christiansen SC
Am J Rhinol Allergy 2011 Nov-Dec;25(6):373-8. doi: 10.2500/ajra.2011.25.3661. PMID: 22185738
New insights into hereditary angio-oedema: Molecular diagnosis and therapy.
Nagy N, Grattan CE, McGrath JA
Australas J Dermatol 2010 Aug;51(3):157-62. doi: 10.1111/j.1440-0960.2010.00649.x. PMID: 20695852
The bradykinin-forming cascade and its role in hereditary angioedema.
Kaplan AP, Joseph K
Ann Allergy Asthma Immunol 2010 Mar;104(3):193-204. doi: 10.1016/j.anai.2010.01.007. PMID: 20377108
Plasminogen activation: biochemistry, physiology, and therapeutics.
Wun TC
Crit Rev Biotechnol 1988;8(2):131-48. doi: 10.3109/07388558809150542. PMID: 2976309

Prognosis

The Pathophysiology of The Antiphospholipid Syndrome: A Perspective From The Blood Coagulation System.
Arreola-Diaz R, Majluf-Cruz A, Sanchez-Torres LE, Hernandez-Juarez J
Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221088576. doi: 10.1177/10760296221088576. PMID: 35317658Free PMC Article
Hereditary angioedema with F12 mutation: factors modifying the clinical phenotype.
Charignon D, Ghannam A, Defendi F, Ponard D, Monnier N, López Trascasa M, Launay D, Caballero T, Djenouhat K, Fain O, Cichon S, Martin L, Drouet C
Allergy 2014 Dec;69(12):1659-65. Epub 2014 Oct 10 doi: 10.1111/all.12515. PMID: 25134986
The burden of illness in patients with hereditary angioedema.
Banerji A
Ann Allergy Asthma Immunol 2013 Nov;111(5):329-36. Epub 2013 Sep 18 doi: 10.1016/j.anai.2013.08.019. PMID: 24125136
Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor.
de Agostini A, Lijnen HR, Pixley RA, Colman RW, Schapira M
J Clin Invest 1984 Jun;73(6):1542-9. doi: 10.1172/JCI111360. PMID: 6725552Free PMC Article
Plasma prekallikrein, factor XII, antithrombin III, C1(-)-inhibitor and alpha 2-macroglobulin in critically ill patients with suspected disseminated intravascular coagulation (DIC).
Lämmle B, Tran TH, Ritz R, Duckert F
Am J Clin Pathol 1984 Oct;82(4):396-404. doi: 10.1093/ajcp/82.4.396. PMID: 6206713

Clinical prediction guides

Platelet surface-associated activation and secretion-mediated inhibition of coagulation factor XII.
Zakharova NV, Artemenko EO, Podoplelova NA, Sveshnikova AN, Demina IA, Ataullakhanov FI, Panteleev MA
PLoS One 2015;10(2):e0116665. Epub 2015 Feb 17 doi: 10.1371/journal.pone.0116665. PMID: 25688860Free PMC Article
The bradykinin-forming cascade and its role in hereditary angioedema.
Kaplan AP, Joseph K
Ann Allergy Asthma Immunol 2010 Mar;104(3):193-204. doi: 10.1016/j.anai.2010.01.007. PMID: 20377108
Pathogenesis of malignant pleural mesothelioma.
Jaurand MC, Fleury-Feith J
Respirology 2005 Jan;10(1):2-8. doi: 10.1111/j.1440-1843.2005.00694.x. PMID: 15691231
Factor XII, plasma prekallikrein, alpha 2-macroglobulin and C1-inhibitor levels in renal allograft recipients during immunosuppression with cyclosporin A--sequential measurements over four months in 17 patients.
Lohri A, Huser B, Lämmle B, Oberholzer M, Thiel G, Duckert F
Thromb Haemost 1987 Dec 18;58(4):993-7. PMID: 2451306
Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor.
de Agostini A, Lijnen HR, Pixley RA, Colman RW, Schapira M
J Clin Invest 1984 Jun;73(6):1542-9. doi: 10.1172/JCI111360. PMID: 6725552Free PMC Article

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