U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sclerosis of the carpal bones

MedGen UID:
1387787
•Concept ID:
C4477088
•
Finding
HPO: HP:0500031

Definition

An elevation in bone density in one or more carpal bones of the hand. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSclerosis of the carpal bones

Professional guidelines

PubMed

Arthroscopically assisted use of injectable bone graft substitutes for management of scaphoid nonunions.
Chu PJ, Shih JT
Arthroscopy 2011 Jan;27(1):31-7. Epub 2010 Oct 8 doi: 10.1016/j.arthro.2010.05.015. PMID: 20934844
Kienbock's disease: diagnosis and treatment.
Allan CH, Joshi A, Lichtman DM
J Am Acad Orthop Surg 2001 Mar-Apr;9(2):128-36. doi: 10.5435/00124635-200103000-00006. PMID: 11281636
Kienböck's disease: conservative management versus radial shortening.
Salmon J, Stanley JK, Trail IA
J Bone Joint Surg Br 2000 Aug;82(6):820-3. doi: 10.1302/0301-620x.82b6.10570. PMID: 10990304

Recent clinical studies

Etiology

Genetic and clinical phenotypic analysis of familial stapes sclerosis caused by an NOG mutation.
Yu R, Jiang H, Liao H, Luo W
BMC Med Genomics 2020 Dec 11;13(1):187. doi: 10.1186/s12920-020-00843-5. PMID: 33308208Free PMC Article
Avascular Necrosis of the Carpal Bones Other Than Kienböck Disease.
Afshar A, Tabrizi A
J Hand Surg Am 2020 Feb;45(2):148-152. Epub 2019 Oct 1 doi: 10.1016/j.jhsa.2019.05.022. PMID: 31585747
Radiographic signs of hook of hamate fracture: evaluation of diagnostic utility.
Spencer J, Hunt SL, Zhang C, Walter C, Everist B
Skeletal Radiol 2019 Dec;48(12):1891-1898. Epub 2019 May 27 doi: 10.1007/s00256-019-03221-0. PMID: 31134315
Kienböck Disease in the Skeletally Immature Patient.
Afshar A
J Hand Surg Am 2018 May;43(5):465-469. Epub 2018 Mar 21 doi: 10.1016/j.jhsa.2018.02.029. PMID: 29573896
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Diagnosis

Classification and Radiographic Characterization of Kienböck Disease.
Lockwood WC, Lauder A
Hand Clin 2022 Nov;38(4):405-415. doi: 10.1016/j.hcl.2022.03.004. PMID: 36244708
Avascular Necrosis of the Carpal Bones Other Than Kienböck Disease.
Afshar A, Tabrizi A
J Hand Surg Am 2020 Feb;45(2):148-152. Epub 2019 Oct 1 doi: 10.1016/j.jhsa.2019.05.022. PMID: 31585747
Radiographic signs of hook of hamate fracture: evaluation of diagnostic utility.
Spencer J, Hunt SL, Zhang C, Walter C, Everist B
Skeletal Radiol 2019 Dec;48(12):1891-1898. Epub 2019 May 27 doi: 10.1007/s00256-019-03221-0. PMID: 31134315
Osteopoikilosis.
Ellanti P, Clarke B, Gray J
Ir J Med Sci 2010 Dec;179(4):615-6. Epub 2010 Oct 1 doi: 10.1007/s11845-010-0595-y. PMID: 20886307
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Therapy

Radiographic signs of hook of hamate fracture: evaluation of diagnostic utility.
Spencer J, Hunt SL, Zhang C, Walter C, Everist B
Skeletal Radiol 2019 Dec;48(12):1891-1898. Epub 2019 May 27 doi: 10.1007/s00256-019-03221-0. PMID: 31134315
Radiographic Assessment of the Robert and Lateral Views in Trapeziometacarpal Osteoarthrosis.
Oheb J, Lansinger Y, Jansen JA, Nguyen JQ, Porembski MA, Rayan GM
Hand Surg 2015;20(2):251-9. doi: 10.1142/S0218810415500203. PMID: 26051765
Arthroscopically assisted use of injectable bone graft substitutes for management of scaphoid nonunions.
Chu PJ, Shih JT
Arthroscopy 2011 Jan;27(1):31-7. Epub 2010 Oct 8 doi: 10.1016/j.arthro.2010.05.015. PMID: 20934844
Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis.
Bilic R, Simic P, Jelic M, Stern-Padovan R, Dodig D, van Meerdervoort HP, Martinovic S, Ivankovic D, Pecina M, Vukicevic S
Int Orthop 2006 Apr;30(2):128-34. Epub 2006 Feb 28 doi: 10.1007/s00264-005-0045-z. PMID: 16506027Free PMC Article
Avascular necrosis of the carpal scaphoid associated with progressive systemic sclerosis.
Kawai H, Tsuyuguchi Y, Yonenobu K, Inoue A, Tada K
Hand 1983 Oct;15(3):270-3. PMID: 6642301

Prognosis

Is osteonecrosis of the lunate bone an underestimated feature of systemic sclerosis? A case series of nine patients and review of literature.
Frerix M, Kröger K, Szalay G, Müller-Ladner U, Tarner IH
Semin Arthritis Rheum 2016 Feb;45(4):446-54. Epub 2015 Aug 4 doi: 10.1016/j.semarthrit.2015.07.010. PMID: 26493463
Temporary scaphocapitate fixation with or without radial shortening for adolescent Kienböck's disease.
Cha SM, Shin HD, Ahn JS, Noh CK
J Pediatr Orthop B 2015 May;24(3):207-14. doi: 10.1097/BPB.0000000000000165. PMID: 25714941
Osteotomy of the radius without shortening for Kienböck disease: a 10-year follow-up.
Blanco RH, Blanco FR
J Hand Surg Am 2012 Nov;37(11):2221-5. Epub 2012 Sep 18 doi: 10.1016/j.jhsa.2012.07.023. PMID: 22995698
Displaced scaphoid waist fractures: the use of a week 4 CT scan to predict the likelihood of union with nonoperative treatment.
Amirfeyz R, Bebbington A, Downing ND, Oni JA, Davis TR
J Hand Surg Eur Vol 2011 Jul;36(6):498-502. Epub 2011 Apr 5 doi: 10.1177/1753193411403092. PMID: 21467089
Analysis of proximal fragment sclerosis and surgical outcome of scaphoid non-union by magnetic resonance imaging.
Sakuma M, Nakamura R, Imaeda T
J Hand Surg Br 1995 Apr;20(2):201-5. doi: 10.1016/s0266-7681(05)80050-6. PMID: 7797970

Clinical prediction guides

Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients.
Tsunakawa Y, Hamada M, Matsunaga Y, Fuseya S, Jeon H, Wakimoto Y, Usui T, Kanai M, Mizuno S, Morito N, Takahashi S
Exp Anim 2019 Feb 26;68(1):103-111. Epub 2018 Oct 26 doi: 10.1538/expanim.18-0093. PMID: 30369533Free PMC Article
Is osteonecrosis of the lunate bone an underestimated feature of systemic sclerosis? A case series of nine patients and review of literature.
Frerix M, Kröger K, Szalay G, Müller-Ladner U, Tarner IH
Semin Arthritis Rheum 2016 Feb;45(4):446-54. Epub 2015 Aug 4 doi: 10.1016/j.semarthrit.2015.07.010. PMID: 26493463
Analysis of proximal fragment sclerosis and surgical outcome of scaphoid non-union by magnetic resonance imaging.
Sakuma M, Nakamura R, Imaeda T
J Hand Surg Br 1995 Apr;20(2):201-5. doi: 10.1016/s0266-7681(05)80050-6. PMID: 7797970
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357
Radiographic signs of union of scaphoid fractures. An analysis of inter-observer agreement and reproducibility.
Dias JJ, Taylor M, Thompson J, Brenkel IJ, Gregg PJ
J Bone Joint Surg Br 1988 Mar;70(2):299-301. doi: 10.1302/0301-620X.70B2.3346310. PMID: 3346310

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...