U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Congenital Hyperthyroidism

MedGen UID:
1393085
•Concept ID:
C1262098
•
Disease or Syndrome

Definition

Hyperthyroidism, the cause of which is present at birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital Hyperthyroidism

Professional guidelines

PubMed

Hyperthyroidism in early infancy: pathogenesis, clinical features and diagnosis with a focus on neonatal hyperthyroidism.
Polak M
Thyroid 1998 Dec;8(12):1171-7. doi: 10.1089/thy.1998.8.1171. PMID: 9920374

Recent clinical studies

Etiology

Screening of congenital hyperthyroidism in Morocco: a pilot study.
Maniar S, Amor C, Bijjou A
East Mediterr Health J 2019 Jan 23;24(11):1066-1073. doi: 10.26719/2018.24.11.1066. PMID: 30701521
Evaluation of inflammatory and oxidative biomarkers in children with well-controlled congenital hypothyroidism.
Qiu YL, Zhu H, Ma SG, Liu H, Li Q, Ji CM
J Pediatr Endocrinol Metab 2015 Jul;28(7-8):761-5. doi: 10.1515/jpem-2014-0428. PMID: 25879312
Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings.
Zoeller RT, Rovet J
J Neuroendocrinol 2004 Oct;16(10):809-18. doi: 10.1111/j.1365-2826.2004.01243.x. PMID: 15500540
Ocular manifestations in children and adolescents with thyrotoxicosis.
Grüters A
Exp Clin Endocrinol Diabetes 1999;107 Suppl 5:S172-4. doi: 10.1055/s-0029-1212178. PMID: 10614915
Congenital hyperthyroidism.
Krude H, Biebermann H, Krohn HP, Dralle H, Grüters A
Exp Clin Endocrinol Diabetes 1997;105 Suppl 4:6-11. doi: 10.1055/s-0029-1211924. PMID: 9439907

Diagnosis

Spatial Distribution of Congenital Hypothyroidism.
Mahaki B, Mehrnejat N, Zabihi M, Dalvi M, Kazemitabaee M
Arch Iran Med 2021 Aug 1;24(8):636-642. doi: 10.34172/aim.2021.90. PMID: 34488332
Hypothyroidism and hyperthyroidism.
Guerri G, Bressan S, Sartori M, Costantini A, Benedetti S, Agostini F, Tezzele S, Cecchin S, Scaramuzza A, Bertelli M
Acta Biomed 2019 Sep 30;90(10-S):83-86. doi: 10.23750/abm.v90i10-S.8765. PMID: 31577260Free PMC Article
Congenital hyperthyroidism: the fetus as a patient.
Polak M, Legac I, Vuillard E, Guibourdenche J, Castanet M, Luton D
Horm Res 2006;65(5):235-42. Epub 2006 Mar 30 doi: 10.1159/000092454. PMID: 16582565
Hyperthyroidism in early infancy: pathogenesis, clinical features and diagnosis with a focus on neonatal hyperthyroidism.
Polak M
Thyroid 1998 Dec;8(12):1171-7. doi: 10.1089/thy.1998.8.1171. PMID: 9920374
Congenital hyperthyroidism.
Krude H, Biebermann H, Krohn HP, Dralle H, Grüters A
Exp Clin Endocrinol Diabetes 1997;105 Suppl 4:6-11. doi: 10.1055/s-0029-1211924. PMID: 9439907

Therapy

Screening of congenital hyperthyroidism in Morocco: a pilot study.
Maniar S, Amor C, Bijjou A
East Mediterr Health J 2019 Jan 23;24(11):1066-1073. doi: 10.26719/2018.24.11.1066. PMID: 30701521
Constitutively active germline mutation of the thyrotropin receptor gene as a cause of congenital hyperthyroidism.
Schwab KO, Gerlich M, Broecker M, Söhlemann P, Derwahl M, Lohse MJ
J Pediatr 1997 Dec;131(6):899-904. doi: 10.1016/s0022-3476(97)70040-4. PMID: 9427897
Properties of thyroid-stimulating hormone and cortisol secretion by the human newborn on the day of birth.
de Zegher F, Vanhole C, Van den Berghe G, Devlieger H, Eggermont E, Veldhuis JD
J Clin Endocrinol Metab 1994 Aug;79(2):576-81. doi: 10.1210/jcem.79.2.8045979. PMID: 8045979
Clinical application of evoked EEG responses in infants. III: congenital hypothyroidism.
Hrbek A, Fällström SP, Karlberg P, Olsson T
Dev Med Child Neurol 1982 Apr;24(2):164-72. doi: 10.1111/j.1469-8749.1982.tb08795.x. PMID: 7095294
Congenital hyperthyroidism.
Pilapil VR, Frame EM
J Fla Med Assoc 1967 Apr;54(4):343-6. PMID: 6068788

Prognosis

Spatial Distribution of Congenital Hypothyroidism.
Mahaki B, Mehrnejat N, Zabihi M, Dalvi M, Kazemitabaee M
Arch Iran Med 2021 Aug 1;24(8):636-642. doi: 10.34172/aim.2021.90. PMID: 34488332
Evaluation of inflammatory and oxidative biomarkers in children with well-controlled congenital hypothyroidism.
Qiu YL, Zhu H, Ma SG, Liu H, Li Q, Ji CM
J Pediatr Endocrinol Metab 2015 Jul;28(7-8):761-5. doi: 10.1515/jpem-2014-0428. PMID: 25879312
Multiple relapses of hyperthyroidism after thyroid surgeries in a patient with long term follow-up of sporadic non-autoimmune hyperthyroidism.
Bircan R, Miehle K, Mladenova G, Ivanova R, Ivanova R, Sarafova A, Borissova AM, Lüblinghoff J, Paschke R
Exp Clin Endocrinol Diabetes 2008 Jun;116(6):341-6. doi: 10.1055/s-2007-1004566. PMID: 18528812
TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5.
Karges B, Krause G, Homoki J, Debatin KM, de Roux N, Karges W
J Endocrinol 2005 Aug;186(2):377-85. doi: 10.1677/joe.1.06208. PMID: 16079263
Ocular manifestations in children and adolescents with thyrotoxicosis.
Grüters A
Exp Clin Endocrinol Diabetes 1999;107 Suppl 5:S172-4. doi: 10.1055/s-0029-1212178. PMID: 10614915

Clinical prediction guides

Spatial Distribution of Congenital Hypothyroidism.
Mahaki B, Mehrnejat N, Zabihi M, Dalvi M, Kazemitabaee M
Arch Iran Med 2021 Aug 1;24(8):636-642. doi: 10.34172/aim.2021.90. PMID: 34488332
Thyroid gland development and defects.
Kratzsch J, Pulzer F
Best Pract Res Clin Endocrinol Metab 2008 Feb;22(1):57-75. doi: 10.1016/j.beem.2007.08.006. PMID: 18279780
Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings.
Zoeller RT, Rovet J
J Neuroendocrinol 2004 Oct;16(10):809-18. doi: 10.1111/j.1365-2826.2004.01243.x. PMID: 15500540
Ocular manifestations in children and adolescents with thyrotoxicosis.
Grüters A
Exp Clin Endocrinol Diabetes 1999;107 Suppl 5:S172-4. doi: 10.1055/s-0029-1212178. PMID: 10614915
Constitutively activating TSH receptor mutations as the cause of toxic thyroid adenoma, multinodular toxic goiter and autosomal dominant non autoimmune hyperthyroidism.
Paschke R
Exp Clin Endocrinol Diabetes 1996;104 Suppl 4:129-32. doi: 10.1055/s-0029-1211720. PMID: 8981020

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...