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Flu-Like Symptoms

MedGen UID:
140262
•Concept ID:
C0392171
•
Sign or Symptom
Synonyms: ILI; Influenza-Like Illness

Definition

Complaints describing a pattern similar to influenza, which may include one or more of the following symptoms: fever, chills, muscle or body aches, cough, sore throat, rhinitis, or fatigue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlu-Like Symptoms

Professional guidelines

PubMed

COVID-19 diagnosis and management: a comprehensive review.
Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, Scarlata S, Agrò FE
J Intern Med 2020 Aug;288(2):192-206. Epub 2020 May 13 doi: 10.1111/joim.13091. PMID: 32348588Free PMC Article
Brucella - Virulence Factors, Pathogenesis and Treatment.
Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A
Pol J Microbiol 2018 Jun 30;67(2):151-161. doi: 10.21307/pjm-2018-029. PMID: 30015453Free PMC Article
EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses.
Belyaev I, Dean A, Eger H, Hubmann G, Jandrisovits R, Kern M, Kundi M, Moshammer H, Lercher P, Müller K, Oberfeld G, Ohnsorge P, Pelzmann P, Scheingraber C, Thill R
Rev Environ Health 2016 Sep 1;31(3):363-97. doi: 10.1515/reveh-2016-0011. PMID: 27454111

Recent clinical studies

Etiology

COVID-19 and the antiphospholipid syndrome.
Serrano M, Espinosa G, Serrano A, Cervera R
Autoimmun Rev 2022 Dec;21(12):103206. Epub 2022 Oct 3 doi: 10.1016/j.autrev.2022.103206. PMID: 36195247Free PMC Article
Discontinuing antidepressants: Pearls and pitfalls.
Zwiebel SJ, Viguera AC
Cleve Clin J Med 2022 Jan 4;89(1):18-26. doi: 10.3949/ccjm.89a.21020. PMID: 34983798
Cardiovascular Manifestations of COVID-19.
Nandy S, Wan SH, Brenes-Salazar J
Curr Cardiol Rev 2021;17(4):e230421187503. doi: 10.2174/1573403X16999201102213827. PMID: 33143614Free PMC Article
A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology.
de Leon J, Ruan CJ, Schoretsanitis G, De Las Cuevas C
Psychother Psychosom 2020;89(4):200-214. Epub 2020 Apr 14 doi: 10.1159/000507638. PMID: 32289791Free PMC Article
Hantavirus.
Hawes S, Seabolt JP
Clin Lab Sci 2003 Winter;16(1):39-42. PMID: 12587657

Diagnosis

Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.
Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A
J Neurol Sci 2021 Sep 15;428:117607. Epub 2021 Aug 3 doi: 10.1016/j.jns.2021.117607. PMID: 34365148Free PMC Article
Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians.
Batah SS, Fabro AT
Respir Med 2021 Jan;176:106239. Epub 2020 Nov 19 doi: 10.1016/j.rmed.2020.106239. PMID: 33246294Free PMC Article
New onset refractory status epilepticus (NORSE).
Sculier C, Gaspard N
Seizure 2019 May;68:72-78. Epub 2018 Sep 29 doi: 10.1016/j.seizure.2018.09.018. PMID: 30482654
EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses.
Belyaev I, Dean A, Eger H, Hubmann G, Jandrisovits R, Kern M, Kundi M, Moshammer H, Lercher P, Müller K, Oberfeld G, Ohnsorge P, Pelzmann P, Scheingraber C, Thill R
Rev Environ Health 2016 Sep 1;31(3):363-97. doi: 10.1515/reveh-2016-0011. PMID: 27454111
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Therapy

Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD-a randomized controlled trial.
Cukoski S, Lindemann CH, Arjune S, Todorova P, Brecht T, Kühn A, Oehm S, Strubl S, Becker I, Kämmerer U, Torres JA, Meyer F, Schömig T, Hokamp NG, Siedek F, Gottschalk I, Benzing T, Schmidt J, Antczak P, Weimbs T, Grundmann F, Müller RU
Cell Rep Med 2023 Nov 21;4(11):101283. Epub 2023 Nov 7 doi: 10.1016/j.xcrm.2023.101283. PMID: 37935200Free PMC Article
Discontinuing antidepressants: Pearls and pitfalls.
Zwiebel SJ, Viguera AC
Cleve Clin J Med 2022 Jan 4;89(1):18-26. doi: 10.3949/ccjm.89a.21020. PMID: 34983798
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.
Wrangle JM, Velcheti V, Patel MR, Garrett-Mayer E, Hill EG, Ravenel JG, Miller JS, Farhad M, Anderton K, Lindsey K, Taffaro-Neskey M, Sherman C, Suriano S, Swiderska-Syn M, Sion A, Harris J, Edwards AR, Rytlewski JA, Sanders CM, Yusko EC, Robinson MD, Krieg C, Redmond WL, Egan JO, Rhode PR, Jeng EK, Rock AD, Wong HC, Rubinstein MP
Lancet Oncol 2018 May;19(5):694-704. Epub 2018 Apr 5 doi: 10.1016/S1470-2045(18)30148-7. PMID: 29628312Free PMC Article
Fluoropolymer-associated illness.
Hays HL, Spiller H
Clin Toxicol (Phila) 2014 Sep-Oct;52(8):848-55. doi: 10.3109/15563650.2014.946610. PMID: 25200453
Flu-like symptoms following botulinum toxin therapy.
Baizabal-Carvallo JF, Jankovic J, Pappert E
Toxicon 2011 Jul;58(1):1-7. Epub 2011 May 19 doi: 10.1016/j.toxicon.2011.04.019. PMID: 21620881

Prognosis

Cardiovascular Manifestations of COVID-19.
Nandy S, Wan SH, Brenes-Salazar J
Curr Cardiol Rev 2021;17(4):e230421187503. doi: 10.2174/1573403X16999201102213827. PMID: 33143614Free PMC Article
Coagulopathy associated with COVID-19.
Bílková S, Hirmerová J
Vnitr Lek 2020 Fall;66(7):402-408. PMID: 33380117
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
New onset refractory status epilepticus (NORSE).
Sculier C, Gaspard N
Seizure 2019 May;68:72-78. Epub 2018 Sep 29 doi: 10.1016/j.seizure.2018.09.018. PMID: 30482654
Hypersensitivity pneumonitis.
Pitcher WD
Am J Med Sci 1990 Oct;300(4):251-66. doi: 10.1097/00000441-199010000-00010. PMID: 2248279

Clinical prediction guides

COVID-19 and cardiovascular manifestations.
Parvu S, Müller K, Dahdal D, Cosmin I, Christodorescu R, Duda-Seiman D, Man D, Sharma A, Dragoi R, Baneu P, Dragan S
Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4509-4519. doi: 10.26355/eurrev_202206_29090. PMID: 35776052
Risk factors prediction, clinical outcomes, and mortality in COVID-19 patients.
Alizadehsani R, Alizadeh Sani Z, Behjati M, Roshanzamir Z, Hussain S, Abedini N, Hasanzadeh F, Khosravi A, Shoeibi A, Roshanzamir M, Moradnejad P, Nahavandi S, Khozeimeh F, Zare A, Panahiazar M, Acharya UR, Islam SMS
J Med Virol 2021 Apr;93(4):2307-2320. Epub 2020 Dec 17 doi: 10.1002/jmv.26699. PMID: 33247599Free PMC Article
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.
Wrangle JM, Velcheti V, Patel MR, Garrett-Mayer E, Hill EG, Ravenel JG, Miller JS, Farhad M, Anderton K, Lindsey K, Taffaro-Neskey M, Sherman C, Suriano S, Swiderska-Syn M, Sion A, Harris J, Edwards AR, Rytlewski JA, Sanders CM, Yusko EC, Robinson MD, Krieg C, Redmond WL, Egan JO, Rhode PR, Jeng EK, Rock AD, Wong HC, Rubinstein MP
Lancet Oncol 2018 May;19(5):694-704. Epub 2018 Apr 5 doi: 10.1016/S1470-2045(18)30148-7. PMID: 29628312Free PMC Article
Chikungunya virus infection: an overview.
Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Recent systematic reviews

COVID-19 and the Immune Response: A Multi-Phasic Approach to the Treatment of COVID-19.
Sapir T, Averch Z, Lerman B, Bodzin A, Fishman Y, Maitra R
Int J Mol Sci 2022 Aug 3;23(15) doi: 10.3390/ijms23158606. PMID: 35955740Free PMC Article
COVID-19 and cardiovascular manifestations.
Parvu S, Müller K, Dahdal D, Cosmin I, Christodorescu R, Duda-Seiman D, Man D, Sharma A, Dragoi R, Baneu P, Dragan S
Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4509-4519. doi: 10.26355/eurrev_202206_29090. PMID: 35776052
Propionyl-L-carnitine for intermittent claudication.
Kamoen V, Vander Stichele R, Campens L, De Bacquer D, Van Bortel L, de Backer TL
Cochrane Database Syst Rev 2021 Dec 26;12(12):CD010117. doi: 10.1002/14651858.CD010117.pub2. PMID: 34954832Free PMC Article
Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.
Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A
J Neurol Sci 2021 Sep 15;428:117607. Epub 2021 Aug 3 doi: 10.1016/j.jns.2021.117607. PMID: 34365148Free PMC Article
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article

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