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Undifferentiated schizophrenia

MedGen UID:
140267
•Concept ID:
C0392322
•
Mental or Behavioral Dysfunction
Synonym: Schizophrenia, atypical
SNOMED CT: Atypical schizophrenia (111484002); Undifferentiated schizophrenia (111484002)

Definition

A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated schizophrenia

Professional guidelines

PubMed

Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.
Grover S, Chakrabarti S, Hazari N, Avasthi A
Psychiatry Res 2017 Mar;249:349-353. Epub 2017 Jan 18 doi: 10.1016/j.psychres.2017.01.042. PMID: 28152470
Weight Gain Risk Factor assessment checklist: overview and recommendation for use.
Treuer T, Pendlebury J, Lockman H, Bushe C, Karagianis J, Raskin J, Lipkovich I
Neuro Endocrinol Lett 2011;32(2):199-205. PMID: 21552187
Interactive risk factors for treatment adherence in a chronic psychotic disorders population.
Corriss DJ, Smith TE, Hull JW, Lim RW, Pratt SI, Romanelli S
Psychiatry Res 1999 Dec 27;89(3):269-74. doi: 10.1016/s0165-1781(99)00111-0. PMID: 10708273

Recent clinical studies

Etiology

Integrated untargeted fecal metabolomics and gut microbiota strategy for screening potential biomarkers associated with schizophrenia.
Gao Y, Liu X, Pan M, Zeng D, Zhou X, Tsunoda M, Zhang Y, Xie X, Wang R, Hu W, Li L, Yang H, Song Y
J Psychiatr Res 2022 Dec;156:628-638. Epub 2022 Nov 7 doi: 10.1016/j.jpsychires.2022.10.072. PMID: 36375230
A Preventive Role of RANTES Genetic Variation against Undifferentiated Schizophrenia.
Saoud H, Ben Afia A, Aflouk Y, Gaha L, Bel Hadj Jrad B
Immunol Invest 2022 Aug;51(6):1843-1855. Epub 2022 Apr 27 doi: 10.1080/08820139.2022.2067001. PMID: 35476033
The validity of the DSM-IV diagnostic classification system of non-affective psychoses.
Korver-Nieberg N, Quee PJ, Boos HB, Simons CJ; GROUP
Aust N Z J Psychiatry 2011 Dec;45(12):1061-8. Epub 2011 Oct 25 doi: 10.3109/00048674.2011.620562. PMID: 22026404
Diagnostic issues in chronic schizophrenia: kraepelinian schizophrenia, undifferentiated schizophrenia, and state-independent negative symptoms.
Keefe RS, Lobel DS, Mohs RC, Silverman JM, Harvey PD, Davidson M, Losonczy MF, Davis KL
Schizophr Res 1991 Mar-Apr;4(2):71-9. doi: 10.1016/0920-9964(91)90026-n. PMID: 2039764
Early longitudinal course of acute-chronic and paranoid--undifferentiated schizophrenia subtypes and schizophreniform disorder.
Marengo JT, Harrow M, Westermeyer JF
J Abnorm Psychol 1991 Nov;100(4):600-3. doi: 10.1037//0021-843x.100.4.600. PMID: 1757674

Diagnosis

Integrated untargeted fecal metabolomics and gut microbiota strategy for screening potential biomarkers associated with schizophrenia.
Gao Y, Liu X, Pan M, Zeng D, Zhou X, Tsunoda M, Zhang Y, Xie X, Wang R, Hu W, Li L, Yang H, Song Y
J Psychiatr Res 2022 Dec;156:628-638. Epub 2022 Nov 7 doi: 10.1016/j.jpsychires.2022.10.072. PMID: 36375230
The validity of the DSM-IV diagnostic classification system of non-affective psychoses.
Korver-Nieberg N, Quee PJ, Boos HB, Simons CJ; GROUP
Aust N Z J Psychiatry 2011 Dec;45(12):1061-8. Epub 2011 Oct 25 doi: 10.3109/00048674.2011.620562. PMID: 22026404
Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences.
Benedetti F, Radaelli D, Poletti S, Falini A, Cavallaro R, Dallaspezia S, Riccaboni R, Scotti G, Smeraldi E
Psychol Med 2011 Mar;41(3):509-19. Epub 2010 Jun 9 doi: 10.1017/S0033291710001108. PMID: 20529416
Diagnostic issues in chronic schizophrenia: kraepelinian schizophrenia, undifferentiated schizophrenia, and state-independent negative symptoms.
Keefe RS, Lobel DS, Mohs RC, Silverman JM, Harvey PD, Davidson M, Losonczy MF, Davis KL
Schizophr Res 1991 Mar-Apr;4(2):71-9. doi: 10.1016/0920-9964(91)90026-n. PMID: 2039764
Early longitudinal course of acute-chronic and paranoid--undifferentiated schizophrenia subtypes and schizophreniform disorder.
Marengo JT, Harrow M, Westermeyer JF
J Abnorm Psychol 1991 Nov;100(4):600-3. doi: 10.1037//0021-843x.100.4.600. PMID: 1757674

Therapy

Postmortem studies on mitochondria in schizophrenia.
Roberts RC
Schizophr Res 2017 Sep;187:17-25. Epub 2017 Feb 9 doi: 10.1016/j.schres.2017.01.056. PMID: 28189530Free PMC Article
Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.
Grover S, Chakrabarti S, Hazari N, Avasthi A
Psychiatry Res 2017 Mar;249:349-353. Epub 2017 Jan 18 doi: 10.1016/j.psychres.2017.01.042. PMID: 28152470
Psychiatric comorbidity in temporal DNET and improvement after surgery.
Landais A, Crespel A, Moulis JL, Coubes P, Gelisse P
Neurochirurgie 2016 Jun;62(3):165-70. Epub 2016 May 26 doi: 10.1016/j.neuchi.2016.02.002. PMID: 27237726
Diagnostic issues in chronic schizophrenia: kraepelinian schizophrenia, undifferentiated schizophrenia, and state-independent negative symptoms.
Keefe RS, Lobel DS, Mohs RC, Silverman JM, Harvey PD, Davidson M, Losonczy MF, Davis KL
Schizophr Res 1991 Mar-Apr;4(2):71-9. doi: 10.1016/0920-9964(91)90026-n. PMID: 2039764
Detection and management of the neuroleptic malignant syndrome.
Bond WS
Clin Pharm 1984 May-Jun;3(3):302-7. PMID: 6145537

Prognosis

Fluctuations in schizophrenic births by year.
Torrey EF, Rawlings RR
Br J Psychiatry 1996 Dec;169(6):772-5. doi: 10.1192/bjp.169.6.772. PMID: 8968637
Early longitudinal course of acute-chronic and paranoid--undifferentiated schizophrenia subtypes and schizophreniform disorder.
Marengo JT, Harrow M, Westermeyer JF
J Abnorm Psychol 1991 Nov;100(4):600-3. doi: 10.1037//0021-843x.100.4.600. PMID: 1757674
Natural history of schizophrenia subtypes. I. Longitudinal study of paranoid, hebephrenic, and undifferentiated schizophrenia.
Fenton WS, McGlashan TH
Arch Gen Psychiatry 1991 Nov;48(11):969-77. doi: 10.1001/archpsyc.1991.01810350009002. PMID: 1747020
Urinary free-cortisol levels in posttraumatic stress disorder patients.
Mason JW, Giller EL, Kosten TR, Ostroff RB, Podd L
J Nerv Ment Dis 1986 Mar;174(3):145-9. doi: 10.1097/00005053-198603000-00003. PMID: 3950596
Subtype stability in schizophrenia.
Kendler KS, Gruenberg AM, Tsuang MT
Am J Psychiatry 1985 Jul;142(7):827-32. doi: 10.1176/ajp.142.7.827. PMID: 4014504

Clinical prediction guides

Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.
Grover S, Chakrabarti S, Hazari N, Avasthi A
Psychiatry Res 2017 Mar;249:349-353. Epub 2017 Jan 18 doi: 10.1016/j.psychres.2017.01.042. PMID: 28152470
Psychiatric comorbidity in temporal DNET and improvement after surgery.
Landais A, Crespel A, Moulis JL, Coubes P, Gelisse P
Neurochirurgie 2016 Jun;62(3):165-70. Epub 2016 May 26 doi: 10.1016/j.neuchi.2016.02.002. PMID: 27237726
The validity of the DSM-IV diagnostic classification system of non-affective psychoses.
Korver-Nieberg N, Quee PJ, Boos HB, Simons CJ; GROUP
Aust N Z J Psychiatry 2011 Dec;45(12):1061-8. Epub 2011 Oct 25 doi: 10.3109/00048674.2011.620562. PMID: 22026404
A case of agitated catatonia.
Cottencin O, Thomas P, Vaiva G, Rascle C, Goudemand M
Pharmacopsychiatry 1999 Jan;32(1):38-40. doi: 10.1055/s-2007-979186. PMID: 10071181
Fluctuations in schizophrenic births by year.
Torrey EF, Rawlings RR
Br J Psychiatry 1996 Dec;169(6):772-5. doi: 10.1192/bjp.169.6.772. PMID: 8968637

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