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Synovial lining hyperplasia

MedGen UID:
140824
•Concept ID:
C0410574
•
Disease or Syndrome
Synonyms: Hypertrophies, Synovial; Hypertrophy, Synovial; Synovial Hypertrophies; Synovial Hypertrophy; Synovial Thickening; Synovial Thickenings; Thickening, Synovial; Thickenings, Synovial
SNOMED CT: Synovial thickening (240206002); Synovial hypertrophy (240206002)
 
HPO: HP:0005186

Definition

Synovial hyperplasia involves proliferation of mesenchymal stromal/stem cells and leads to synovial thickening, which can be observed radiographically. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSynovial lining hyperplasia

Conditions with this feature

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome
MedGen UID:
349226
•Concept ID:
C1859690
•
Disease or Syndrome
The camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is an autosomal recessive condition characterized by the association of congenital or early-onset camptodactyly and noninflammatory arthropathy with synovial hyperplasia. Progressive coxa vara deformity and/or noninflammatory pericardial or pleural effusions are found in some patients (summary by Faivre et al., 2000).
See: Condition Record
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome

Professional guidelines

PubMed

Apoptosis in the rheumatoid arthritis synovial membrane: modulation by disease-modifying anti-rheumatic drug treatment.
Smith MD, Weedon H, Papangelis V, Walker J, Roberts-Thomson PJ, Ahern MJ
Rheumatology (Oxford) 2010 May;49(5):862-75. Epub 2010 Feb 10 doi: 10.1093/rheumatology/kep467. PMID: 20147446

Recent clinical studies

Etiology

Tuberculosis of the knee.
Hoffman EB, Allin J, Campbell JA, Leisegang FM
Clin Orthop Relat Res 2002 May;(398):100-6. doi: 10.1097/00003086-200205000-00014. PMID: 11964637

Diagnosis

Rheumatoid Arthritis Morning Stiffness Is Associated With Synovial Fibrin and Neutrophils.
Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie MP, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM
Arthritis Rheumatol 2020 Apr;72(4):557-564. Epub 2020 Feb 12 doi: 10.1002/art.41141. PMID: 31612614Free PMC Article
Tuberculosis of the knee.
Hoffman EB, Allin J, Campbell JA, Leisegang FM
Clin Orthop Relat Res 2002 May;(398):100-6. doi: 10.1097/00003086-200205000-00014. PMID: 11964637

Therapy

Apoptosis in the rheumatoid arthritis synovial membrane: modulation by disease-modifying anti-rheumatic drug treatment.
Smith MD, Weedon H, Papangelis V, Walker J, Roberts-Thomson PJ, Ahern MJ
Rheumatology (Oxford) 2010 May;49(5):862-75. Epub 2010 Feb 10 doi: 10.1093/rheumatology/kep467. PMID: 20147446
Tuberculosis of the knee.
Hoffman EB, Allin J, Campbell JA, Leisegang FM
Clin Orthop Relat Res 2002 May;(398):100-6. doi: 10.1097/00003086-200205000-00014. PMID: 11964637

Prognosis

The role of synovitis in osteoarthritis pathogenesis.
Scanzello CR, Goldring SR
Bone 2012 Aug;51(2):249-57. Epub 2012 Feb 22 doi: 10.1016/j.bone.2012.02.012. PMID: 22387238Free PMC Article
Tuberculosis of the knee.
Hoffman EB, Allin J, Campbell JA, Leisegang FM
Clin Orthop Relat Res 2002 May;(398):100-6. doi: 10.1097/00003086-200205000-00014. PMID: 11964637

Clinical prediction guides

Rheumatoid Arthritis Morning Stiffness Is Associated With Synovial Fibrin and Neutrophils.
Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie MP, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM
Arthritis Rheumatol 2020 Apr;72(4):557-564. Epub 2020 Feb 12 doi: 10.1002/art.41141. PMID: 31612614Free PMC Article
Ultrasound colour Doppler is associated with synovial pathology in biopsies from hand joints in rheumatoid arthritis patients: a cross-sectional study.
Andersen M, Ellegaard K, Hebsgaard JB, Christensen R, Torp-Pedersen S, Kvist PH, Søe N, Rømer J, Vendel N, Bartels EM, Danneskiold-Samsøe B, Bliddal H
Ann Rheum Dis 2014 Apr;73(4):678-83. Epub 2013 Mar 8 doi: 10.1136/annrheumdis-2012-202669. PMID: 23475981
Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis.
Fan L, Wang Q, Liu R, Zong M, He D, Zhang H, Ding Y, Ma J
Arthritis Res Ther 2012 Dec 10;14(6):R266. doi: 10.1186/ar4112. PMID: 23217276Free PMC Article
The role of synovitis in osteoarthritis pathogenesis.
Scanzello CR, Goldring SR
Bone 2012 Aug;51(2):249-57. Epub 2012 Feb 22 doi: 10.1016/j.bone.2012.02.012. PMID: 22387238Free PMC Article
Tuberculosis of the knee.
Hoffman EB, Allin J, Campbell JA, Leisegang FM
Clin Orthop Relat Res 2002 May;(398):100-6. doi: 10.1097/00003086-200205000-00014. PMID: 11964637

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