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Neoplasms, Multiple Primary

MedGen UID:
14323
•Concept ID:
C0027663
•
Neoplastic Process
Synonyms: Multiple Primary Neoplasm; Multiple Primary Neoplasms; Multiple Primary Neoplasms, Synchronous; Neoplasm, Multiple Primary; Neoplasm, Synchronous; Neoplasms, Synchronous; Neoplasms, Synchronous Multiple Primary; Primary Neoplasm, Multiple; Primary Neoplasms, Multiple; Synchronous Multiple Primary Neoplasms; Synchronous Neoplasm; Synchronous Neoplasms

Definition

Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites. [from MeSH]

Professional guidelines

PubMed

Diagnostic and treatment considerations for synchronous cancer of the ovary and endometrium.
Glassman D, Rauh-Hain JA, Tandon N, Fattahi N
Int J Gynecol Cancer 2023 Jan 3;33(1):118-122. doi: 10.1136/ijgc-2022-004140. PMID: 36603893
Does synchronous early head and neck cancer with esophageal cancer need treatment after preoperative chemotherapy?
Kanamori K, Kurita D, Hirano Y, Ishiyama K, Oguma J, Masutomi K, Daiko H
Gen Thorac Cardiovasc Surg 2022 Mar;70(3):280-284. Epub 2021 Nov 27 doi: 10.1007/s11748-021-01744-9. PMID: 34837129
Genetic susceptibility to multiple primary neoplasms in the upper aero-digestive tract: genotype score and phenotype correlation.
Hussain T, Kotnis A, Sarin R, Mulherkar R
Cancer Lett 2013 May 10;332(1):46-54. Epub 2013 Jan 21 doi: 10.1016/j.canlet.2013.01.017. PMID: 23348701

Recent clinical studies

Etiology

Multiple primary melanomas: A literature review.
Apostu AP, Ungureanu L, Halmagyi SR, Trufin II, Șenilă SC
Medicine (Baltimore) 2023 Jul 28;102(30):e34378. doi: 10.1097/MD.0000000000034378. PMID: 37505174Free PMC Article
Landscapes of synchronous multiple primary cancers detected by next-generation sequencing.
Kong Y, Li J, Lin H, Liang X, Zhou X
FEBS Open Bio 2022 Nov;12(11):1996-2005. Epub 2022 Oct 2 doi: 10.1002/2211-5463.13491. PMID: 36128740Free PMC Article
Genetic and immune characteristics of multiple primary lung cancers and lung metastases.
Yang R, Li P, Wang D, Wang L, Yin J, Yu B, Li M, Wang S, Wang Y
Thorac Cancer 2021 Oct;12(19):2544-2550. Epub 2021 Sep 12 doi: 10.1111/1759-7714.14134. PMID: 34510768Free PMC Article
Multiple Primary Melanomas Occurring Around the Same Time: A Review of Terminology and Implications.
Shih S, Dai C, Shih T, Khachemoune A
J Drugs Dermatol 2020 May 1;19(5):471-474. PMID: 32484627
Multicentric osteosarcoma.
Hameed S, Vijayan S, Naik M, Rao S
Singapore Med J 2012 Oct;53(10):e214-7. PMID: 23112033

Diagnosis

Landscapes of synchronous multiple primary cancers detected by next-generation sequencing.
Kong Y, Li J, Lin H, Liang X, Zhou X
FEBS Open Bio 2022 Nov;12(11):1996-2005. Epub 2022 Oct 2 doi: 10.1002/2211-5463.13491. PMID: 36128740Free PMC Article
Lung Cancer Staging.
Kutob L, Schneider F
Surg Pathol Clin 2020 Mar;13(1):57-71. Epub 2019 Dec 18 doi: 10.1016/j.path.2019.10.003. PMID: 32005435
Multiple primary lung cancer: A literature review.
Romaszko AM, Doboszyńska A
Adv Clin Exp Med 2018 May;27(5):725-730. doi: 10.17219/acem/68631. PMID: 29790681
Multicentric osteosarcoma.
Hameed S, Vijayan S, Naik M, Rao S
Singapore Med J 2012 Oct;53(10):e214-7. PMID: 23112033
Primary and secondary neoplasms of the spleen.
Kaza RK, Azar S, Al-Hawary MM, Francis IR
Cancer Imaging 2010 Aug 13;10(1):173-82. doi: 10.1102/1470-7330.2010.0026. PMID: 20713317Free PMC Article

Therapy

Immunotherapy for bilateral multiple ground glass opacities: An exploratory study for synchronous multiple primary lung cancer.
Xu L, Shi M, Wang S, Li M, Yin W, Zhang J, Zhu J, Jiang F, Xia W, Qiu N, Zhang Z, Huang J, Ma Z, Meng F, Zhu H, Dong G, Wang J, Yin R
Front Immunol 2022;13:1009621. Epub 2022 Oct 25 doi: 10.3389/fimmu.2022.1009621. PMID: 36389707Free PMC Article
Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature.
De Luca A, Frusone F, Vergine M, Cocchiara R, La Torre G, Ballesio L, Monti M, Amabile MI
In Vivo 2019 Jul-Aug;33(4):1313-1324. doi: 10.21873/invivo.11605. PMID: 31280224Free PMC Article
Gastrointestinal stromal tumors: diagnosis, therapy and follow-up care in Austria.
Bareck E, Ba-Ssalamah A, Brodowicz T, Eisterer W, Häfner M, Högenauer C, Kastner U, Kühr T, Längle F, Liegl-Atzwanger B, Schoppmann SF, Widmann G, Wrba F, Zacherl J, Ploner F; Austrian representatives of Medical and Surgical Oncology, Pathology, Radiology, Nuclear Medicine, Gastroenterology, and Laboratory Medicine
Wien Med Wochenschr 2013 Mar;163(5-6):137-52. Epub 2013 Mar 19 doi: 10.1007/s10354-013-0187-3. PMID: 23508516
Double pituitary adenomas.
Iacovazzo D, Bianchi A, Lugli F, Milardi D, Giampietro A, Lucci-Cordisco E, Doglietto F, Lauriola L, De Marinis L
Endocrine 2013 Apr;43(2):452-7. Epub 2013 Jan 17 doi: 10.1007/s12020-013-9876-3. PMID: 23325364
Multiple primary melanoma.
Moseley HS, Giuliano AE, Storm FK 3rd, Clark WH, Robinson DS, Morton DL
Cancer 1979 Mar;43(3):939-44. doi: 10.1002/1097-0142(197903)43:3<939::aid-cncr2820430323>3.0.co;2-n. PMID: 427733

Prognosis

Multiple primary melanomas: A literature review.
Apostu AP, Ungureanu L, Halmagyi SR, Trufin II, Șenilă SC
Medicine (Baltimore) 2023 Jul 28;102(30):e34378. doi: 10.1097/MD.0000000000034378. PMID: 37505174Free PMC Article
Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Nie Y, Wang X, Yang F, Zhou Z, Wang J, Chen K
Clin Lung Cancer 2021 Jul;22(4):341-350.e3. Epub 2020 Nov 5 doi: 10.1016/j.cllc.2020.10.022. PMID: 33243621
Clinicopathologic features and prognosis of synchronous and metachronous multiple primary colorectal cancer.
Zhang C, Cui M, Xing J, Yang H, Yao Z, Zhang N, Su X
Clin Transl Oncol 2021 Feb;23(2):335-343. Epub 2020 Jun 26 doi: 10.1007/s12094-020-02426-3. PMID: 32592156
Multiple Primary Melanomas Occurring Around the Same Time: A Review of Terminology and Implications.
Shih S, Dai C, Shih T, Khachemoune A
J Drugs Dermatol 2020 May 1;19(5):471-474. PMID: 32484627
Multiple primary melanomas.
Johnson TM, Hamilton T, Lowe L
J Am Acad Dermatol 1998 Sep;39(3):422-7. doi: 10.1016/s0190-9622(98)70318-4. PMID: 9738776

Clinical prediction guides

Genetic and immune characteristics of multiple primary lung cancers and lung metastases.
Yang R, Li P, Wang D, Wang L, Yin J, Yu B, Li M, Wang S, Wang Y
Thorac Cancer 2021 Oct;12(19):2544-2550. Epub 2021 Sep 12 doi: 10.1111/1759-7714.14134. PMID: 34510768Free PMC Article
Multiomics analysis reveals a distinct response mechanism in multiple primary lung adenocarcinoma after neoadjuvant immunotherapy.
Zhang C, Yin K, Liu SY, Yan LX, Su J, Wu YL, Zhang XC, Zhong WZ, Yang XN
J Immunother Cancer 2021 Apr;9(4) doi: 10.1136/jitc-2020-002312. PMID: 33820821Free PMC Article
Discrepancy Between Clinical Diagnosis and Whole-exome Sequencing-based Clonality Analysis of Synchronous Multiple Oral Cancers.
Nishii N, Hirotsu Y, Koida N, Takahashi Y, Takagawa Y, Amemiya K, Oyama T, Mochizuki H, Furusawa-Nishii E, Harada H, Omata M
Anticancer Res 2021 Feb;41(2):1035-1040. doi: 10.21873/anticanres.14859. PMID: 33517312
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
Pritchard AL, Johansson PA, Nathan V, Howlie M, Symmons J, Palmer JM, Hayward NK
PLoS One 2018;13(4):e0194098. Epub 2018 Apr 11 doi: 10.1371/journal.pone.0194098. PMID: 29641532Free PMC Article
Bilateral breast cancer.
Fracchia AA, Borgen PI
Semin Surg Oncol 1991 Sep-Oct;7(5):300-5. doi: 10.1002/ssu.2980070513. PMID: 1775816

Recent systematic reviews

Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Nie Y, Wang X, Yang F, Zhou Z, Wang J, Chen K
Clin Lung Cancer 2021 Jul;22(4):341-350.e3. Epub 2020 Nov 5 doi: 10.1016/j.cllc.2020.10.022. PMID: 33243621
Survival in patients with multiple primary melanomas: Systematic review and meta-analysis.
Peek G, Olsen CM, Baade P, Youlden DR, Aitken JF, Green AC, Khosrotehrani K
J Am Acad Dermatol 2020 Nov;83(5):1406-1414. Epub 2020 Apr 1 doi: 10.1016/j.jaad.2020.03.076. PMID: 32246965
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654
Prognosis of synchronous and metachronous multiple primary lung cancers: systematic review and meta-analysis.
Jiang L, He J, Shi X, Shen J, Liang W, Yang C, He J
Lung Cancer 2015 Mar;87(3):303-10. Epub 2015 Jan 14 doi: 10.1016/j.lungcan.2014.12.013. PMID: 25617985
Diagnosis of multiple primary lung cancer: a systematic review.
Xue X, Liu Y, Pan L, Wang Y, Wang K, Zhang M, Wang P, Wang J
J Int Med Res 2013 Dec;41(6):1779-87. doi: 10.1177/0300060513504707. PMID: 24265329

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