Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Hypersensitivity pneumonitis

MedGen UID:: 1446
•Concept ID:: C0002390
•: Disease or Syndrome

Synonyms:	Allergic interstitial pneumonitis; Allergic pneumonitis; Extrinsic allergic alveolitis; Extrinsic allergic pneumonia hypersensitivity Pneumonitis
SNOMED CT:	Extrinsic allergic alveolitis (37471005); Extrinsic allergic bronchiolo-alveolitis (37471005); Hypersensitivity pneumonia (37471005); Allergic alveolitis (37471005); Allergic pneumonitis (37471005); Allergic interstitial pneumonitis (37471005); Hypersensitivity pneumonitis (37471005); Bagpipe lung (37471005); EAA - Extrinsic allergic alveolitis (37471005)
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

HPO:	HP:0006516
Monarch Initiative:	MONDO:0017853
Orphanet:	ORPHA31740

Definition

Hypersensitivity pneumonitis involves inhalation of an antigen. This leads to an exaggerated immune response and a following inflammation of the alveoli within the lungs. The main feature of chronic hypersensitivity pneumonitis on lung biopsies is expansion of the interstitium by lymphocytes accompanied by an occasional multinucleated giant cell or loose granuloma. After exposure to the provoking antigen, following symptoms can be seen [from HPO]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHypersensitivity pneumonitis

Phenotypic abnormality
- Abnormality of the respiratory system
  - Abnormal respiratory system physiology
    - Abnormal respiratory system morphology
      - Abnormality of the lung
        Abnormal pulmonary interstitial morphology
        Hypersensitivity pneumonitis
        House allergic alveolitis

Follow this link to review classifications for Hypersensitivity pneumonitis in Orphanet.

Conditions with this feature

Hypersensitivity pneumonitis, familial

MedGen UID:: 326724
•Concept ID:: C1840386
•: Disease or Syndrome

An instance of hypersensitivity pneumonitis that is caused by an inherited modification of the individual's genome.

See: Condition Record

Hypersensitivity pneumonitis, familial

Professional guidelines

PubMed

Immunomodulatory treatment of interstitial lung disease.

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712 Free PMC Article

Diagnosis, course and management of hypersensitivity pneumonitis.

Hamblin M, Prosch H, Vašáková M
Eur Respir Rev 2022 Mar 31;31(163) Epub 2022 Feb 9 doi: 10.1183/16000617.0169-2021. PMID: 35140104 Free PMC Article

Diagnosis of Hypersensitivity Pneumonitis in Adults. An Official ATS/JRS/ALAT Clinical Practice Guideline.

Raghu G, Remy-Jardin M, Ryerson CJ, Myers JL, Kreuter M, Vasakova M, Bargagli E, Chung JH, Collins BF, Bendstrup E, Chami HA, Chua AT, Corte TJ, Dalphin JC, Danoff SK, Diaz-Mendoza J, Duggal A, Egashira R, Ewing T, Gulati M, Inoue Y, Jenkins AR, Johannson KA, Johkoh T, Tamae-Kakazu M, Kitaichi M, Knight SL, Koschel D, Lederer DJ, Mageto Y, Maier LA, Matiz C, Morell F, Nicholson AG, Patolia S, Pereira CA, Renzoni EA, Salisbury ML, Selman M, Walsh SLF, Wuyts WA, Wilson KC
Am J Respir Crit Care Med 2020 Aug 1;202(3):e36-e69. doi: 10.1164/rccm.202005-2032ST. PMID: 32706311 Free PMC Article

See all (111)

Recent clinical studies

Etiology

Usual interstitial pneumonia as a stand-alone diagnostic entity: the case for a paradigm shift?

Selman M, Pardo A, Wells AU
Lancet Respir Med 2023 Feb;11(2):188-196. Epub 2023 Jan 11 doi: 10.1016/S2213-2600(22)00475-1. PMID: 36640788

Immunomodulatory treatment of interstitial lung disease.

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712 Free PMC Article

An update on interstitial lung disease.

Mudawi D, Heyes K, Hastings R, Rivera-Ortega P, Chaudhuri N
Br J Hosp Med (Lond) 2021 Jul 2;82(7):1-14. Epub 2021 Jul 20 doi: 10.12968/hmed.2020.0556. PMID: 34338019

Nintedanib in patients with progressive fibrosing interstitial lung diseases-subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial.

Wells AU, Flaherty KR, Brown KK, Inoue Y, Devaraj A, Richeldi L, Moua T, Crestani B, Wuyts WA, Stowasser S, Quaresma M, Goeldner RG, Schlenker-Herceg R, Kolb M; INBUILD trial investigators
Lancet Respir Med 2020 May;8(5):453-460. Epub 2020 Mar 5 doi: 10.1016/S2213-2600(20)30036-9. PMID: 32145830

Mosaic Attenuation: Etiology, Methods of Differentiation, and Pitfalls.

Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445

See all (691)

Diagnosis

Integration and Application of Clinical Practice Guidelines for the Diagnosis of Idiopathic Pulmonary Fibrosis and Fibrotic Hypersensitivity Pneumonitis.

Marinescu DC, Raghu G, Remy-Jardin M, Travis WD, Adegunsoye A, Beasley MB, Chung JH, Churg A, Cottin V, Egashira R, Fernández Pérez ER, Inoue Y, Johannson KA, Kazerooni EA, Khor YH, Lynch DA, Müller NL, Myers JL, Nicholson AG, Rajan S, Saito-Koyama R, Troy L, Walsh SLF, Wells AU, Wijsenbeek MS, Wright JL, Ryerson CJ
Chest 2022 Sep;162(3):614-629. Epub 2022 Jun 20 doi: 10.1016/j.chest.2022.06.013. PMID: 35738345

Hypersensitivity pneumonitis: new concepts and classifications.

Churg A
Mod Pathol 2022 Jan;35(Suppl 1):15-27. Epub 2021 Sep 16 doi: 10.1038/s41379-021-00866-y. PMID: 34531525

Hypersensitivity pneumonitis: Current concepts in pathogenesis, diagnosis, and treatment.

Barnes H, Troy L, Lee CT, Sperling A, Strek M, Glaspole I
Allergy 2022 Feb;77(2):442-453. Epub 2021 Jul 29 doi: 10.1111/all.15017. PMID: 34293188

An update on interstitial lung disease.

Mudawi D, Heyes K, Hastings R, Rivera-Ortega P, Chaudhuri N
Br J Hosp Med (Lond) 2021 Jul 2;82(7):1-14. Epub 2021 Jul 20 doi: 10.12968/hmed.2020.0556. PMID: 34338019

Diagnosis and Evaluation of Hypersensitivity Pneumonitis: CHEST Guideline and Expert Panel Report.

Fernández Pérez ER, Travis WD, Lynch DA, Brown KK, Johannson KA, Selman M, Ryu JH, Wells AU, Tony Huang YC, Pereira CAC, Scholand MB, Villar A, Inase N, Evans RB, Mette SA, Frazer-Green L
Chest 2021 Aug;160(2):e97-e156. Epub 2021 Apr 20 doi: 10.1016/j.chest.2021.03.066. PMID: 33861992

See all (1166)

Therapy

Immunomodulatory treatment of interstitial lung disease.

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712 Free PMC Article

Recent advances in the management of pulmonary hypertension with interstitial lung disease.

Waxman AB, Elia D, Adir Y, Humbert M, Harari S
Eur Respir Rev 2022 Sep 30;31(165) Epub 2022 Jul 12 doi: 10.1183/16000617.0220-2021. PMID: 35831007 Free PMC Article

Hypersensitivity pneumonitis.

Costabel U, Miyazaki Y, Pardo A, Koschel D, Bonella F, Spagnolo P, Guzman J, Ryerson CJ, Selman M
Nat Rev Dis Primers 2020 Aug 6;6(1):65. doi: 10.1038/s41572-020-0191-z. PMID: 32764620

Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases.

Wollin L, Distler JHW, Redente EF, Riches DWH, Stowasser S, Schlenker-Herceg R, Maher TM, Kolb M
Eur Respir J 2019 Sep;54(3) Epub 2019 Sep 19 doi: 10.1183/13993003.00161-2019. PMID: 31285305 Free PMC Article

See all (643)

Prognosis

Pleuroparenchymal fibroelastosis.

Cottin V, Si-Mohamed S, Diesler R, Bonniaud P, Valenzuela C
Curr Opin Pulm Med 2022 Sep 1;28(5):432-440. Epub 2022 Jul 18 doi: 10.1097/MCP.0000000000000907. PMID: 35855575

Diagnosis, course and management of hypersensitivity pneumonitis.

Hamblin M, Prosch H, Vašáková M
Eur Respir Rev 2022 Mar 31;31(163) Epub 2022 Feb 9 doi: 10.1183/16000617.0169-2021. PMID: 35140104 Free PMC Article

Hypersensitivity pneumonitis.

Costabel U, Miyazaki Y, Pardo A, Koschel D, Bonella F, Spagnolo P, Guzman J, Ryerson CJ, Selman M
Nat Rev Dis Primers 2020 Aug 6;6(1):65. doi: 10.1038/s41572-020-0191-z. PMID: 32764620

Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases.

Cottin V, Hirani NA, Hotchkin DL, Nambiar AM, Ogura T, Otaola M, Skowasch D, Park JS, Poonyagariyagorn HK, Wuyts W, Wells AU
Eur Respir Rev 2018 Dec 31;27(150) Epub 2018 Dec 21 doi: 10.1183/16000617.0076-2018. PMID: 30578335 Free PMC Article

Idiopathic non-specific interstitial pneumonia.

Belloli EA, Beckford R, Hadley R, Flaherty KR
Respirology 2016 Feb;21(2):259-68. Epub 2015 Nov 13 doi: 10.1111/resp.12674. PMID: 26564810

See all (463)

Clinical prediction guides

Interstitial Lung Disease: A Review.

Maher TM
JAMA 2024 May 21;331(19):1655-1665. doi: 10.1001/jama.2024.3669. PMID: 38648021

Recent advances in the management of pulmonary hypertension with interstitial lung disease.

Waxman AB, Elia D, Adir Y, Humbert M, Harari S
Eur Respir Rev 2022 Sep 30;31(165) Epub 2022 Jul 12 doi: 10.1183/16000617.0220-2021. PMID: 35831007 Free PMC Article

Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis.

Bowman WS, Newton CA, Linderholm AL, Neely ML, Pugashetti JV, Kaul B, Vo V, Echt GA, Leon W, Shah RJ, Huang Y, Garcia CK, Wolters PJ, Oldham JM
Lancet Respir Med 2022 Jun;10(6):593-602. Epub 2022 Jan 18 doi: 10.1016/S2213-2600(21)00503-8. PMID: 35063079 Free PMC Article

Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases.

See all (454)

Recent systematic reviews

Risk factors associated with mortality in hypersensitivity pneumonitis: a meta-analysis.

Dasgupta S, Bhattacharya A, Abhijit RD, Roy Chowdhury S, Chaudhury K
Expert Rev Respir Med 2022 Jul;16(7):801-811. Epub 2022 Jul 25 doi: 10.1080/17476348.2022.2100352. PMID: 35819125

Nintedanib in Progressive Pulmonary Fibrosis: A Systematic Review and Meta-Analysis.

Ghazipura M, Mammen MJ, Herman DD, Hon SM, Bissell BD, Macrea M, Kheir F, Khor YH, Knight SL, Raghu G, Wilson KC, Hossain T
Ann Am Thorac Soc 2022 Jun;19(6):1040-1049. doi: 10.1513/AnnalsATS.202103-343OC. PMID: 35499854

Occupational causes of hypersensitivity pneumonitis: a systematic review and compendium.

Kongsupon N, Walters GI, Sadhra SS
Occup Med (Lond) 2021 Oct 1;71(6-7):255-259. doi: 10.1093/occmed/kqab082. PMID: 34370035 Free PMC Article

Transbronchial Biopsy and Cryobiopsy in the Diagnosis of Hypersensitivity Pneumonitis among Patients with Interstitial Lung Disease.

Chami HA, Diaz-Mendoza J, Chua A, Duggal A, Jenkins AR, Knight SL, Patolia S, Tamae-Kakazu M, Raghu G, Wilson KC
Ann Am Thorac Soc 2021 Jan;18(1):148-161. doi: 10.1513/AnnalsATS.202005-421OC. PMID: 32810411

Bronchoalveolar lavage fluid lymphocytosis in chronic hypersensitivity pneumonitis: a systematic review and meta-analysis.

Adderley N, Humphreys CJ, Barnes H, Ley B, Premji ZA, Johannson KA
Eur Respir J 2020 Aug;56(2) Epub 2020 Aug 6 doi: 10.1183/13993003.00206-2020. PMID: 32265306

See all (14)

MedGen

National Center for Biotechnology Information

Send to:

Hypersensitivity pneumonitis

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity