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Ear infection

MedGen UID:
147064
•Concept ID:
C0699744
•
Disease or Syndrome
Synonyms: Ear Infection; Ear Infections; Infection, Ear; Infections, Ear
SNOMED CT: Ear infection (129127001); Infection of ear (129127001)
 
Monarch Initiative: MONDO:0021666

Definition

A viral or bacterial infection that affects the external, middle, or inner ear. It may follow an upper respiratory infection. Signs and symptoms include pain, ear discharge, ear fullness, hearing loss, vertigo, nausea, and vomiting. [from NCI]

Professional guidelines

PubMed

International consensus (ICON) on management of otitis media with effusion in children.
Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Feb;135(1S):S33-S39. Epub 2018 Feb 3 doi: 10.1016/j.anorl.2017.11.009. PMID: 29398506
Clinical Practice Guideline: Otitis Media with Effusion (Update).
Rosenfeld RM, Shin JJ, Schwartz SR, Coggins R, Gagnon L, Hackell JM, Hoelting D, Hunter LL, Kummer AW, Payne SC, Poe DS, Veling M, Vila PM, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2016 Feb;154(1 Suppl):S1-S41. doi: 10.1177/0194599815623467. PMID: 26832942
A benefit-risk assessment of ofloxacin otic solution in ear infection.
Wai TK, Tong MC
Drug Saf 2003;26(6):405-20. doi: 10.2165/00002018-200326060-00003. PMID: 12688832

Recent clinical studies

Etiology

Optical Identification of Middle Ear Infection.
Prasad A, Hasan SMA, Gartia MR
Molecules 2020 May 9;25(9) doi: 10.3390/molecules25092239. PMID: 32397569Free PMC Article
International consensus (ICON) on management of otitis media with effusion in children.
Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Feb;135(1S):S33-S39. Epub 2018 Feb 3 doi: 10.1016/j.anorl.2017.11.009. PMID: 29398506
Oro-Nasal Communication.
Sahoo NK, Desai AP, Roy ID, Kulkarni V
J Craniofac Surg 2016 Sep;27(6):e529-33. doi: 10.1097/SCS.0000000000002815. PMID: 27607130
Clinical Practice Guideline: Otitis Media with Effusion (Update).
Rosenfeld RM, Shin JJ, Schwartz SR, Coggins R, Gagnon L, Hackell JM, Hoelting D, Hunter LL, Kummer AW, Payne SC, Poe DS, Veling M, Vila PM, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2016 Feb;154(1 Suppl):S1-S41. doi: 10.1177/0194599815623467. PMID: 26832942
Masked mastoiditis.
Holt GR, Gates GA
Laryngoscope 1983 Aug;93(8):1034-7. doi: 10.1288/00005537-198308000-00011. PMID: 6877011

Diagnosis

Nasopharyngeal Tuberculosis.
Ahmed S, Mustahsan SM, Jamil B, Ilyas F
J Coll Physicians Surg Pak 2022 Apr;32(4):S39-S40. doi: 10.29271/jcpsp.2022.Supp1.S39. PMID: 35633007
Optical Identification of Middle Ear Infection.
Prasad A, Hasan SMA, Gartia MR
Molecules 2020 May 9;25(9) doi: 10.3390/molecules25092239. PMID: 32397569Free PMC Article
International consensus (ICON) on management of otitis media with effusion in children.
Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Feb;135(1S):S33-S39. Epub 2018 Feb 3 doi: 10.1016/j.anorl.2017.11.009. PMID: 29398506
Clinical Practice Guideline: Otitis Media with Effusion (Update).
Rosenfeld RM, Shin JJ, Schwartz SR, Coggins R, Gagnon L, Hackell JM, Hoelting D, Hunter LL, Kummer AW, Payne SC, Poe DS, Veling M, Vila PM, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2016 Feb;154(1 Suppl):S1-S41. doi: 10.1177/0194599815623467. PMID: 26832942
Masked mastoiditis.
Holt GR, Gates GA
Laryngoscope 1983 Aug;93(8):1034-7. doi: 10.1288/00005537-198308000-00011. PMID: 6877011

Therapy

Optical Identification of Middle Ear Infection.
Prasad A, Hasan SMA, Gartia MR
Molecules 2020 May 9;25(9) doi: 10.3390/molecules25092239. PMID: 32397569Free PMC Article
Gambogic Acid and Its Role in Chronic Diseases.
Pandey MK, Karelia D, Amin SG
Adv Exp Med Biol 2016;928:375-395. doi: 10.1007/978-3-319-41334-1_15. PMID: 27671824
Clinical Practice Guideline: Otitis Media with Effusion (Update).
Rosenfeld RM, Shin JJ, Schwartz SR, Coggins R, Gagnon L, Hackell JM, Hoelting D, Hunter LL, Kummer AW, Payne SC, Poe DS, Veling M, Vila PM, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2016 Feb;154(1 Suppl):S1-S41. doi: 10.1177/0194599815623467. PMID: 26832942
A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy.
Wright A, Hawkins CH, Anggård EE, Harper DR
Clin Otolaryngol 2009 Aug;34(4):349-57. doi: 10.1111/j.1749-4486.2009.01973.x. PMID: 19673983
Masked mastoiditis.
Holt GR, Gates GA
Laryngoscope 1983 Aug;93(8):1034-7. doi: 10.1288/00005537-198308000-00011. PMID: 6877011

Prognosis

Pediatric temporomandibular joint (TMJ) arthritis, an elusive complication of acute mastoiditis.
Cohen Atsmoni S, Hennedige A, Richardson D, De S
Int J Pediatr Otorhinolaryngol 2022 Jul;158:111163. Epub 2022 Apr 27 doi: 10.1016/j.ijporl.2022.111163. PMID: 35500398
Ear microbiota and middle ear disease: a longitudinal pilot study of Aboriginal children in a remote south Australian setting.
Taylor SL, Papanicolas LE, Richards A, Ababor F, Kang WX, Choo JM, Woods C, Wesselingh SL, Ooi EH, MacFarlane P, Rogers GB
BMC Microbiol 2022 Jan 13;22(1):24. doi: 10.1186/s12866-022-02436-x. PMID: 35026986Free PMC Article
Vibrio alginolyticus infections in the USA, 1988-2012.
Jacobs Slifka KM, Newton AE, Mahon BE
Epidemiol Infect 2017 May;145(7):1491-1499. Epub 2017 Feb 16 doi: 10.1017/S0950268817000140. PMID: 28202099Free PMC Article
Viral-bacterial interactions in acute otitis media.
Marom T, Nokso-Koivisto J, Chonmaitree T
Curr Allergy Asthma Rep 2012 Dec;12(6):551-8. doi: 10.1007/s11882-012-0303-2. PMID: 22968233Free PMC Article
Masked mastoiditis.
Holt GR, Gates GA
Laryngoscope 1983 Aug;93(8):1034-7. doi: 10.1288/00005537-198308000-00011. PMID: 6877011

Clinical prediction guides

COVID-19 and Acute Otitis Media in Children: A Case Series.
Frost HM, Sebastian T, Keith A, Kurtz M, Dominguez SR, Parker SK, Jenkins TC
J Prim Care Community Health 2022 Jan-Dec;13:21501319221082351. doi: 10.1177/21501319221082351. PMID: 35289210Free PMC Article
Radiological and Audiological Prediction for Ossicular Fixation in Chronic Otitis Media and Tympanic Membrane Perforation.
Motegi M, Yamamoto Y, Akutsu T, Tada T, Kurihara S, Takahashi M, Sampei S, Morino T, Yamamoto K, Sakurai Y, Kojima H
Otol Neurotol 2022 Jan 1;43(1):80-89. doi: 10.1097/MAO.0000000000003346. PMID: 34510119
Ear Infection Trajectories and Academic, Behavioral, and Quality-of-Life Outcomes: A Population-Based Longitudinal Study.
Wang J, Quach J, Sung V, Carew P, Wake M
J Dev Behav Pediatr 2021 Sep 1;42(7):588-596. doi: 10.1097/DBP.0000000000000931. PMID: 34518499
Differentiating Acute Otitis Media and Acute Mastoiditis in Hospitalized Children.
Laulajainen-Hongisto A, Aarnisalo AA, Jero J
Curr Allergy Asthma Rep 2016 Oct;16(10):72. doi: 10.1007/s11882-016-0654-1. PMID: 27613655
Hypertrophic pachymeningitis.
Dziedzic T, Wojciechowski J, Nowak A, Marchel A
Childs Nerv Syst 2015 Jul;31(7):1025-31. Epub 2015 Mar 15 doi: 10.1007/s00381-015-2680-z. PMID: 25771924

Recent systematic reviews

Association between atopic dermatitis and extracutaneous bacterial and mycobacterial infections: A systematic review and meta-analysis.
Serrano L, Patel KR, Silverberg JI
J Am Acad Dermatol 2019 Apr;80(4):904-912. Epub 2018 Nov 22 doi: 10.1016/j.jaad.2018.11.028. PMID: 30471316
Air Pollution and Otitis Media in Children: A Systematic Review of Literature.
Bowatte G, Tham R, Perret JL, Bloom MS, Dong G, Waidyatillake N, Bui D, Morgan GG, Jalaludin B, Lodge CJ, Dharmage SC
Int J Environ Res Public Health 2018 Feb 3;15(2) doi: 10.3390/ijerph15020257. PMID: 29401661Free PMC Article
Vaccines for preventing influenza in healthy children.
Jefferson T, Rivetti A, Di Pietrantonj C, Demicheli V
Cochrane Database Syst Rev 2018 Feb 1;2(2):CD004879. doi: 10.1002/14651858.CD004879.pub5. PMID: 29388195Free PMC Article
Bilateral versus unilateral hearing aids for bilateral hearing impairment in adults.
Schilder AG, Chong LY, Ftouh S, Burton MJ
Cochrane Database Syst Rev 2017 Dec 19;12(12):CD012665. doi: 10.1002/14651858.CD012665.pub2. PMID: 29256573Free PMC Article
Nutritional factors in the pathogenesis of ear disease in children: a systematic review.
Elemraid MA, Mackenzie IJ, Fraser WD, Brabin BJ
Ann Trop Paediatr 2009 Jun;29(2):85-99. doi: 10.1179/146532809X440707. PMID: 19460262

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