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Oxygen saturation below reference range

MedGen UID:
148179
•Concept ID:
C0746961
•
Finding
Synonyms: Desaturation; Low Blood Oxygen Saturation; Low oxygen saturation; Oxygen Saturation Decreased
SNOMED CT: Low oxygen saturation (449171008); Oxygen saturation below reference range (449171008)

Definition

A low level of the degree to which oxygen is bound to hemoglobin given as a percentage calculated by dividing the maximum oxygen capacity into the actual oxygen content and multiplying by 100. Oxygen saturation usually is measured using pulse oximetry. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOxygen saturation below reference range

Professional guidelines

PubMed

Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.
Struyf T, Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Leeflang MM, Spijker R, Hooft L, Emperador D, Domen J, Horn SRA, Van den Bruel A; Cochrane COVID-19 Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2021 Feb 23;2(2):CD013665. doi: 10.1002/14651858.CD013665.pub2. PMID: 33620086Free PMC Article

Recent clinical studies

Etiology

Automated oxygen delivery for preterm infants with respiratory dysfunction.
Stafford IG, Lai NM, Tan K
Cochrane Database Syst Rev 2023 Nov 30;11(11):CD013294. doi: 10.1002/14651858.CD013294.pub2. PMID: 38032241Free PMC Article
The severity of obstructive sleep apnoea does not influence ambient IGF-I levels.
Lynch J, Kyriakakis N, Seejore K, Nix M, Watts S, Ghosh D, Murray RD
Clin Endocrinol (Oxf) 2021 Mar;94(3):434-442. Epub 2020 Nov 15 doi: 10.1111/cen.14360. PMID: 33128265
The effect of atmospheric pressure on oxygen saturation and dyspnea: the Tromsø study.
Dohmen LME, Spigt M, Melbye H
Int J Biometeorol 2020 Jul;64(7):1103-1110. Epub 2020 Mar 3 doi: 10.1007/s00484-020-01883-3. PMID: 32125519Free PMC Article
Accuracy of pulse oximetry in preterm and term infants is insufficient to determine arterial oxygen saturation and tension.
Wackernagel D, Blennow M, Hellström A
Acta Paediatr 2020 Nov;109(11):2251-2257. Epub 2020 Mar 6 doi: 10.1111/apa.15225. PMID: 32043645
A graphical method for comparing nocturnal oxygen saturation profiles in individuals and populations: Application to healthy infants and preterm neonates.
Terrill PI, Dakin C, Edwards BA, Wilson SJ, MacLean JE
Pediatr Pulmonol 2018 May;53(5):645-655. Epub 2018 Mar 24 doi: 10.1002/ppul.23987. PMID: 29575753

Diagnosis

Near infrared spectroscopy in monitoring of head and neck microvascular free flaps.
Czako L, Simko K, Sovis M, Vidova I, Sufliarsky B, Odnoga P, Galis B
Bratisl Lek Listy 2023;124(7):513-519. doi: 10.4149/BLL_2023_079. PMID: 37218473
Cardiorespiratory Monitoring Data during Sleep in Healthy Canadian Infants.
Vézina K, Mariasine J, Young R, Reyna M, Lu Z, Subbarao P, Moraes TJ, Becker AB, Turvey SE, Sears MR, Lefebvre DL, Azad MB, Rasmussen C, Pei J, Narang I, Mandhane PJ
Ann Am Thorac Soc 2020 Oct;17(10):1238-1246. doi: 10.1513/AnnalsATS.201909-703OC. PMID: 32678717
Accuracy of pulse oximetry in preterm and term infants is insufficient to determine arterial oxygen saturation and tension.
Wackernagel D, Blennow M, Hellström A
Acta Paediatr 2020 Nov;109(11):2251-2257. Epub 2020 Mar 6 doi: 10.1111/apa.15225. PMID: 32043645
Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants.
Askie LM, Darlow BA, Davis PG, Finer N, Stenson B, Vento M, Whyte R
Cochrane Database Syst Rev 2017 Apr 11;4(4):CD011190. doi: 10.1002/14651858.CD011190.pub2. PMID: 28398697Free PMC Article
When should oxygen be given to children at high altitude? A systematic review to define altitude-specific hypoxaemia.
Subhi R, Smith K, Duke T
Arch Dis Child 2009 Jan;94(1):6-10. Epub 2008 Oct 1 doi: 10.1136/adc.2008.138362. PMID: 18829620

Therapy

Automated oxygen delivery for preterm infants with respiratory dysfunction.
Stafford IG, Lai NM, Tan K
Cochrane Database Syst Rev 2023 Nov 30;11(11):CD013294. doi: 10.1002/14651858.CD013294.pub2. PMID: 38032241Free PMC Article
Agreement of somatic and renal near-infrared spectroscopy with reference blood samples during a controlled hypoxia sequence: a healthy volunteer study.
De Keijzer IN, Massari D, Niezen CK, Bokkers RPH, Vos JJ, Scheeren TWL
J Clin Monit Comput 2023 Jun;37(3):805-814. Epub 2022 Dec 4 doi: 10.1007/s10877-022-00944-9. PMID: 36463540Free PMC Article
Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants.
Askie LM, Darlow BA, Davis PG, Finer N, Stenson B, Vento M, Whyte R
Cochrane Database Syst Rev 2017 Apr 11;4(4):CD011190. doi: 10.1002/14651858.CD011190.pub2. PMID: 28398697Free PMC Article
When do infants need additional inspired oxygen? A review of the current literature.
Poets CF
Pediatr Pulmonol 1998 Dec;26(6):424-8. doi: 10.1002/(sici)1099-0496(199812)26:6<424::aid-ppul7>3.0.co;2-g. PMID: 9888217
Study of oxygen saturation, breathing pattern and arrhythmias in patients of interstitial lung disease during sleep.
Hira HS, Sharma RK
Indian J Chest Dis Allied Sci 1997 Jul-Sep;39(3):157-62. PMID: 9357149

Prognosis

The severity of obstructive sleep apnoea does not influence ambient IGF-I levels.
Lynch J, Kyriakakis N, Seejore K, Nix M, Watts S, Ghosh D, Murray RD
Clin Endocrinol (Oxf) 2021 Mar;94(3):434-442. Epub 2020 Nov 15 doi: 10.1111/cen.14360. PMID: 33128265
Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants.
Askie LM, Darlow BA, Davis PG, Finer N, Stenson B, Vento M, Whyte R
Cochrane Database Syst Rev 2017 Apr 11;4(4):CD011190. doi: 10.1002/14651858.CD011190.pub2. PMID: 28398697Free PMC Article
Physiological impact of the N95 filtering facepiece respirator on healthcare workers.
Roberge RJ, Coca A, Williams WJ, Powell JB, Palmiero AJ
Respir Care 2010 May;55(5):569-77. PMID: 20420727
When should oxygen be given to children at high altitude? A systematic review to define altitude-specific hypoxaemia.
Subhi R, Smith K, Duke T
Arch Dis Child 2009 Jan;94(1):6-10. Epub 2008 Oct 1 doi: 10.1136/adc.2008.138362. PMID: 18829620
Study of oxygen saturation, breathing pattern and arrhythmias in patients of interstitial lung disease during sleep.
Hira HS, Sharma RK
Indian J Chest Dis Allied Sci 1997 Jul-Sep;39(3):157-62. PMID: 9357149

Clinical prediction guides

Observational study to define reference ranges for the 3% oxygen desaturation index during sleep in healthy children under 12 years using oximetry motion-resistant technology.
Ong JWY, Williams D, Gavlak JC, Liddle N, Lowe P, Evans HJ
Arch Dis Child 2021 Jun;106(6):583-586. Epub 2020 Oct 20 doi: 10.1136/archdischild-2020-320066. PMID: 33082136
The effect of atmospheric pressure on oxygen saturation and dyspnea: the Tromsø study.
Dohmen LME, Spigt M, Melbye H
Int J Biometeorol 2020 Jul;64(7):1103-1110. Epub 2020 Mar 3 doi: 10.1007/s00484-020-01883-3. PMID: 32125519Free PMC Article
Heart rate, respiratory rate, apnoeas and peripheral arterial oxygen saturation in healthy term neonates during quiet sleep.
Bohnhorst B, Seidel K, Böhne C, Peter C, Pirr S
Acta Paediatr 2019 Feb;108(2):231-238. Epub 2018 Jul 13 doi: 10.1111/apa.14470. PMID: 29926973
When should oxygen be given to children at high altitude? A systematic review to define altitude-specific hypoxaemia.
Subhi R, Smith K, Duke T
Arch Dis Child 2009 Jan;94(1):6-10. Epub 2008 Oct 1 doi: 10.1136/adc.2008.138362. PMID: 18829620
When do infants need additional inspired oxygen? A review of the current literature.
Poets CF
Pediatr Pulmonol 1998 Dec;26(6):424-8. doi: 10.1002/(sici)1099-0496(199812)26:6<424::aid-ppul7>3.0.co;2-g. PMID: 9888217

Recent systematic reviews

Automated oxygen delivery for preterm infants with respiratory dysfunction.
Stafford IG, Lai NM, Tan K
Cochrane Database Syst Rev 2023 Nov 30;11(11):CD013294. doi: 10.1002/14651858.CD013294.pub2. PMID: 38032241Free PMC Article
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.
Struyf T, Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Leeflang MM, Spijker R, Hooft L, Emperador D, Domen J, Horn SRA, Van den Bruel A; Cochrane COVID-19 Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2021 Feb 23;2(2):CD013665. doi: 10.1002/14651858.CD013665.pub2. PMID: 33620086Free PMC Article
Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants.
Askie LM, Darlow BA, Davis PG, Finer N, Stenson B, Vento M, Whyte R
Cochrane Database Syst Rev 2017 Apr 11;4(4):CD011190. doi: 10.1002/14651858.CD011190.pub2. PMID: 28398697Free PMC Article
When should oxygen be given to children at high altitude? A systematic review to define altitude-specific hypoxaemia.
Subhi R, Smith K, Duke T
Arch Dis Child 2009 Jan;94(1):6-10. Epub 2008 Oct 1 doi: 10.1136/adc.2008.138362. PMID: 18829620

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