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Tonsil cancer

MedGen UID:
148341
•Concept ID:
C0751560
•
Neoplastic Process
Synonyms: Cancer of the Tonsil; Cancer of Tonsil; Cancer, Tonsil; Cancer, Tonsillar; Cancers, Tonsil; Cancers, Tonsillar; Tonsil Cancer; Tonsil Cancers; Tonsillar Cancer; Tonsillar Cancers
SNOMED CT: Malignant tumor of faucial tonsil (363393007); Malignant tumor of palatine tonsil (363393007); Cancer of tonsil (363393007); Malignant neoplasm of palatine tonsil (363393007); Malignant neoplasm of faucial tonsil (363393007); CA - Cancer of tonsil (363393007); Malignant tumor of tonsil (363393007)
 
Monarch Initiative: MONDO:0006998

Definition

A primary or metastatic malignant neoplasm that affects the tonsil. [from NCI]

Professional guidelines

PubMed

Treatment outcomes and radiotherapy deintensification strategies in human papillomavirus-associated tonsil cancer.
Lee J, Kim K, Kim KH, Keum KC, Kim HR, Hong MH, Choi EC, Kim SH, Koh YW, Lee CG
Radiat Oncol 2022 Dec 20;17(1):209. doi: 10.1186/s13014-022-02177-1. PMID: 36539912Free PMC Article
Treatment, survival, and costs of oropharyngeal cancer care in the elderly.
Gourin CG, Fakhry C, Quon H, Kang H, Kiess AP, Herbert RJ, Eisele DW, Frick KD
Laryngoscope 2018 May;128(5):1103-1112. Epub 2017 Oct 8 doi: 10.1002/lary.26887. PMID: 28988469
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307

Recent clinical studies

Etiology

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Treatment outcomes and radiotherapy deintensification strategies in human papillomavirus-associated tonsil cancer.
Lee J, Kim K, Kim KH, Keum KC, Kim HR, Hong MH, Choi EC, Kim SH, Koh YW, Lee CG
Radiat Oncol 2022 Dec 20;17(1):209. doi: 10.1186/s13014-022-02177-1. PMID: 36539912Free PMC Article
Pediatric Tonsil Cancer: A National and Institutional Perspective.
Adil EA, Medina G, Cunningham MJ
J Pediatr 2018 Jun;197:255-261.e1. Epub 2018 Mar 21 doi: 10.1016/j.jpeds.2018.01.022. PMID: 29571929
Human papillomavirus and head and neck cancer: a systematic review and meta-analysis.
Hobbs CG, Sterne JA, Bailey M, Heyderman RS, Birchall MA, Thomas SJ
Clin Otolaryngol 2006 Aug;31(4):259-66. doi: 10.1111/j.1749-4486.2006.01246.x. PMID: 16911640
Tonsil cancer.
Bopp FP, White JA
J La State Med Soc 1989 Apr;141(4):11-4. PMID: 2656893

Diagnosis

Treatment outcomes and radiotherapy deintensification strategies in human papillomavirus-associated tonsil cancer.
Lee J, Kim K, Kim KH, Keum KC, Kim HR, Hong MH, Choi EC, Kim SH, Koh YW, Lee CG
Radiat Oncol 2022 Dec 20;17(1):209. doi: 10.1186/s13014-022-02177-1. PMID: 36539912Free PMC Article
Cancer risk among World Trade Center rescue and recovery workers: A review.
Boffetta P, Hall CB, Todd AC, Goldfarb DG, Schymura MJ, Li J, Cone JE, Zeig-Owens R
CA Cancer J Clin 2022 Jul;72(4):308-314. Epub 2022 Mar 24 doi: 10.3322/caac.21723. PMID: 35325473
Pediatric Tonsil Cancer: A National and Institutional Perspective.
Adil EA, Medina G, Cunningham MJ
J Pediatr 2018 Jun;197:255-261.e1. Epub 2018 Mar 21 doi: 10.1016/j.jpeds.2018.01.022. PMID: 29571929
Human papillomavirus and head and neck cancer: a systematic review and meta-analysis.
Hobbs CG, Sterne JA, Bailey M, Heyderman RS, Birchall MA, Thomas SJ
Clin Otolaryngol 2006 Aug;31(4):259-66. doi: 10.1111/j.1749-4486.2006.01246.x. PMID: 16911640
Tonsil cancer.
Bopp FP, White JA
J La State Med Soc 1989 Apr;141(4):11-4. PMID: 2656893

Therapy

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Safety and efficacy of parsaclisib in combination with obinutuzumab and bendamustine in patients with relapsed or refractory follicular lymphoma (CITADEL-102): A phase 1 study.
Hamadani M, Coleman M, Boccia R, Duras J, Hutchings M, Zinzani PL, Cordoba R, Oreiro MB, Williams V, Liu H, Stouffs M, Langmuir P, Sancho JM
Hematol Oncol 2023 Dec;41(5):848-857. Epub 2023 Jul 26 doi: 10.1002/hon.3209. PMID: 37496298
Cancer risk among World Trade Center rescue and recovery workers: A review.
Boffetta P, Hall CB, Todd AC, Goldfarb DG, Schymura MJ, Li J, Cone JE, Zeig-Owens R
CA Cancer J Clin 2022 Jul;72(4):308-314. Epub 2022 Mar 24 doi: 10.3322/caac.21723. PMID: 35325473
Swallowing After Primary TORS and Unilateral or Bilateral Radiation for Low- to Intermediate-Risk Tonsil Cancer.
Barbon CEA, Yao CMK, Peterson CB, Moreno AC, Goepfert RP, Johnson FM, Chronowski GM, Fuller CD, Gross ND, Hutcheson KA
Otolaryngol Head Neck Surg 2022 Sep;167(3):484-493. Epub 2021 Nov 16 doi: 10.1177/01945998211059967. PMID: 34784256Free PMC Article
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307

Prognosis

Surgical Treatment for Advanced Oropharyngeal Cancer: A Narrative Review.
Maniaci A, Hao SP, Cancemi F, Giardini D, Checcoli E, Soprani F, Iannella G, Vicini C, Cocuzza S, La Mantia I, Fakhry N, De Vito A
Medicina (Kaunas) 2023 Feb 7;59(2) doi: 10.3390/medicina59020304. PMID: 36837506Free PMC Article
Treatment outcomes and radiotherapy deintensification strategies in human papillomavirus-associated tonsil cancer.
Lee J, Kim K, Kim KH, Keum KC, Kim HR, Hong MH, Choi EC, Kim SH, Koh YW, Lee CG
Radiat Oncol 2022 Dec 20;17(1):209. doi: 10.1186/s13014-022-02177-1. PMID: 36539912Free PMC Article
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Pediatric Tonsil Cancer: A National and Institutional Perspective.
Adil EA, Medina G, Cunningham MJ
J Pediatr 2018 Jun;197:255-261.e1. Epub 2018 Mar 21 doi: 10.1016/j.jpeds.2018.01.022. PMID: 29571929
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307

Clinical prediction guides

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Treatment outcomes and radiotherapy deintensification strategies in human papillomavirus-associated tonsil cancer.
Lee J, Kim K, Kim KH, Keum KC, Kim HR, Hong MH, Choi EC, Kim SH, Koh YW, Lee CG
Radiat Oncol 2022 Dec 20;17(1):209. doi: 10.1186/s13014-022-02177-1. PMID: 36539912Free PMC Article
Cancer risk among World Trade Center rescue and recovery workers: A review.
Boffetta P, Hall CB, Todd AC, Goldfarb DG, Schymura MJ, Li J, Cone JE, Zeig-Owens R
CA Cancer J Clin 2022 Jul;72(4):308-314. Epub 2022 Mar 24 doi: 10.3322/caac.21723. PMID: 35325473
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307

Recent systematic reviews

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Association of Unilateral Radiotherapy With Contralateral Lymph Node Failure Among Patients With Squamous Cell Carcinoma of the Tonsil: A Systematic Review and Meta-analysis.
Razavian NB, D'Agostino RB Jr, Steber CR, Helis CA, Hughes RT
JAMA Netw Open 2023 Feb 1;6(2):e2255209. doi: 10.1001/jamanetworkopen.2022.55209. PMID: 36753275Free PMC Article
Is there an increased risk of cancer among spouses of patients with an HPV-related cancer: A systematic review.
Mirghani H, Sturgis EM, Aupérin A, Monsonego J, Blanchard P
Oral Oncol 2017 Apr;67:138-145. Epub 2017 Feb 28 doi: 10.1016/j.oraloncology.2017.02.024. PMID: 28351568
Human papillomavirus and head and neck cancer: a systematic review and meta-analysis.
Hobbs CG, Sterne JA, Bailey M, Heyderman RS, Birchall MA, Thomas SJ
Clin Otolaryngol 2006 Aug;31(4):259-66. doi: 10.1111/j.1749-4486.2006.01246.x. PMID: 16911640

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