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Amnionitis

MedGen UID:
1490
•Concept ID:
C0002631
•
Disease or Syndrome
Synonym: Amnionitides
SNOMED CT: Amniotic cavity infection (10573002); Infection of amniotic cavity (10573002); Amnionitis (10573002)
 
Monarch Initiative: MONDO:0020710

Definition

Inflammation of the amnion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmnionitis

Professional guidelines

PubMed

The antibiotic treatment of PPROM study: systemic maternal and fetal markers and perinatal outcomes.
Mercer BM, Crouse DT, Goldenberg RL, Miodovnik M, Mapp DC, Meis PJ, Dombrowski MP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Am J Obstet Gynecol 2012 Feb;206(2):145.e1-9. Epub 2011 Sep 8 doi: 10.1016/j.ajog.2011.08.028. PMID: 22000668Free PMC Article
Prenatal diagnosis of thalassemia and hemoglobinopathies in Thailand: experience from 100 pregnancies.
Fucharoen S, Winichagoon P, Thonglairoam V, Siriboon W, Siritanaratkul N, Kanokpongsakdi S, Vantanasiri C
Southeast Asian J Trop Med Public Health 1991 Mar;22(1):16-29. PMID: 1948258
Clinical utility of the nonstress test in the conservative management of women with preterm spontaneous premature rupture of the membranes.
Smith CV, Greenspoon J, Phelan JP, Platt LD
J Reprod Med 1987 Jan;32(1):1-4. PMID: 3560057

Recent clinical studies

Etiology

Maternal Origins of Neonatal Infections: What Do Obstetrician-Gynecologist Should/Could Do?
Germano C, Messina A, Massaro A, Attini R, Leo L, Manzoni P, Masturzo B
Am J Perinatol 2022 Dec;39(S 01):S31-S41. Epub 2022 Dec 19 doi: 10.1055/s-0042-1758858. PMID: 36535368
Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
Pathological staging of chorioamnionitis contributes to complications in preterm infants.
Miao J, Ren Z, Rao Y, Xia X, Wang J, Xu F, Zhang X, Yang J
Ital J Pediatr 2020 Sep 11;46(1):127. doi: 10.1186/s13052-020-00895-4. PMID: 32917243Free PMC Article
Streptococci and the genital tract.
Rowen D
Int J STD AIDS 1993 Mar-Apr;4(2):63-6. doi: 10.1177/095646249300400201. PMID: 8476967
Neonatal sepsis.
Driggers DA, Deiss F, Swedberg J, Johnson RB, Steiner JF
Am Fam Physician 1985 Aug;32(2):129-34. PMID: 3895874

Diagnosis

Pathological staging of chorioamnionitis contributes to complications in preterm infants.
Miao J, Ren Z, Rao Y, Xia X, Wang J, Xu F, Zhang X, Yang J
Ital J Pediatr 2020 Sep 11;46(1):127. doi: 10.1186/s13052-020-00895-4. PMID: 32917243Free PMC Article
Role of the infections in recurrent spontaneous abortion.
Nigro G, Mazzocco M, Mattia E, Di Renzo GC, Carta G, Anceschi MM
J Matern Fetal Neonatal Med 2011 Aug;24(8):983-9. Epub 2011 Jan 24 doi: 10.3109/14767058.2010.547963. PMID: 21261443
Bacterial vaginosis.
Sobel JD
Br J Clin Pract Suppl 1990 Sep;71:65-9. PMID: 2091736
Neonatal sepsis.
Driggers DA, Deiss F, Swedberg J, Johnson RB, Steiner JF
Am Fam Physician 1985 Aug;32(2):129-34. PMID: 3895874
Epidemic perinatal listeriosis.
Lennon D, Lewis B, Mantell C, Becroft D, Dove B, Farmer K, Tonkin S, Yeates N, Stamp R, Mickleson K
Pediatr Infect Dis 1984 Jan-Feb;3(1):30-4. doi: 10.1097/00006454-198401000-00008. PMID: 6701102

Therapy

Maternal Origins of Neonatal Infections: What Do Obstetrician-Gynecologist Should/Could Do?
Germano C, Messina A, Massaro A, Attini R, Leo L, Manzoni P, Masturzo B
Am J Perinatol 2022 Dec;39(S 01):S31-S41. Epub 2022 Dec 19 doi: 10.1055/s-0042-1758858. PMID: 36535368
Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
Antibiotic therapy for preterm premature rupture of membranes.
Mercer BM
Clin Obstet Gynecol 1998 Jun;41(2):461-8. doi: 10.1097/00003081-199806000-00026. PMID: 9646977
Clinical role of amnio-infusion.
Ouzounian JG, Paul RH
Baillieres Clin Obstet Gynaecol 1996 Jun;10(2):259-72. doi: 10.1016/s0950-3552(96)80037-x. PMID: 8836484
Neonatal sepsis.
Driggers DA, Deiss F, Swedberg J, Johnson RB, Steiner JF
Am Fam Physician 1985 Aug;32(2):129-34. PMID: 3895874

Prognosis

Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
The role of anaerobic bacteria in bacteremia.
Brook I
Anaerobe 2010 Jun;16(3):183-9. Epub 2009 Dec 16 doi: 10.1016/j.anaerobe.2009.12.001. PMID: 20025984
Mode of delivery in the early preterm infant (<28 weeks).
Drife J
BJOG 2006 Dec;113 Suppl 3:81-5. doi: 10.1111/j.1471-0528.2006.01129.x. PMID: 17206971
Streptococcus pneumoniae infections in the neonate.
Hoffman JA, Mason EO, Schutze GE, Tan TQ, Barson WJ, Givner LB, Wald ER, Bradley JS, Yogev R, Kaplan SL
Pediatrics 2003 Nov;112(5):1095-102. doi: 10.1542/peds.112.5.1095. PMID: 14595052
Antibiotic therapy for preterm premature rupture of membranes.
Mercer BM
Clin Obstet Gynecol 1998 Jun;41(2):461-8. doi: 10.1097/00003081-199806000-00026. PMID: 9646977

Clinical prediction guides

Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
An elevated maternal serum C-reactive protein in the context of intra-amniotic inflammation is an indicator that the development of amnionitis, an intense fetal and AF inflammatory response are likely in patients with preterm labor: clinical implications.
Park CW, Yoon BH, Park JS, Jun JK
J Matern Fetal Neonatal Med 2013 Jun;26(9):847-53. doi: 10.3109/14767058.2013.783806. PMID: 23484918
Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis.
Been JV, Degraeuwe PL, Kramer BW, Zimmermann LJ
BJOG 2011 Jan;118(2):113-22. Epub 2010 Nov 4 doi: 10.1111/j.1471-0528.2010.02751.x. PMID: 21054759
Fetal breathing movements within 24 hours of delivery in prematurity are related to histologic and clinical evidence of amnionitis.
Sherer DM, Spong CY, Salafia CM
Am J Perinatol 1997 Jul;14(6):337-40. doi: 10.1055/s-2007-994156. PMID: 9217954
Clinical amnionitis and endometritis in patients with premature rupture of membranes: endocervical prostaglandin E2 gel versus oxytocin for induction of labor.
Malik N, Gittens L, Gonzalez D, Bardeguez A, Ganesh V, Apuzzio J
Obstet Gynecol 1996 Oct;88(4 Pt 1):540-3. doi: 10.1016/0029-7844(96)00266-9. PMID: 8841214

Recent systematic reviews

Prevalence of Urinary Tract Infection and Its Associated Factors among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis.
Getaneh T, Negesse A, Dessie G, Desta M, Tigabu A
Biomed Res Int 2021;2021:6551526. Epub 2021 Dec 1 doi: 10.1155/2021/6551526. PMID: 34901276Free PMC Article
Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis.
Been JV, Degraeuwe PL, Kramer BW, Zimmermann LJ
BJOG 2011 Jan;118(2):113-22. Epub 2010 Nov 4 doi: 10.1111/j.1471-0528.2010.02751.x. PMID: 21054759
Amnioinfusion for preterm rupture of membranes.
Hofmeyr GJ
Cochrane Database Syst Rev 2000;(2):CD000942. doi: 10.1002/14651858.CD000942. PMID: 10796224
Amnioinfusion for umbilical cord compression in labour.
Hofmeyr GJ
Cochrane Database Syst Rev 2000;(2):CD000013. doi: 10.1002/14651858.CD000013. PMID: 10796084

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