U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Serotonin syndrome

MedGen UID:
152119
•Concept ID:
C0699828
•
Injury or Poisoning
Synonyms: Serotonin Syndrome; Serotonin Syndromes; Syndrome, Serotonin; Syndromes, Serotonin
SNOMED CT: Serotonin syndrome (371089000); Serotonergic syndrome (371089000)
 
Monarch Initiative: MONDO:0018546

Definition

Serotoninergic syndrome is characterized by an excess of serotonin in the central nervous system, associated with the use of various agents, including selective serotonin reuptake inhibitors (SSRIs). [from MONDO]

Professional guidelines

PubMed

Diagnosis and management of generalized anxiety disorder and panic disorder in adults.
Locke AB, Kirst N, Shultz CG
Am Fam Physician 2015 May 1;91(9):617-24. PMID: 25955736
Combination therapy with monoamine oxidase inhibitors and other antidepressants or stimulants: strategies for the management of treatment-resistant depression.
Thomas SJ, Shin M, McInnis MG, Bostwick JR
Pharmacotherapy 2015 Apr;35(4):433-49. doi: 10.1002/phar.1576. PMID: 25884531
Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management.
Perry PJ, Wilborn CA
Ann Clin Psychiatry 2012 May;24(2):155-62. PMID: 22563571

Recent systematic reviews

Linezolid-associated serotonin toxicity: a systematic review.
Elbarbry F, Moshirian N
Eur J Clin Pharmacol 2023 Jul;79(7):875-883. Epub 2023 May 2 doi: 10.1007/s00228-023-03500-9. PMID: 37129603
Tapentadol Versus Tramadol: A Narrative and Comparative Review of Their Pharmacological, Efficacy and Safety Profiles in Adult Patients.
Roulet L, Rollason V, Desmeules J, Piguet V
Drugs 2021 Jul;81(11):1257-1272. Epub 2021 Jul 1 doi: 10.1007/s40265-021-01515-z. PMID: 34196947Free PMC Article
Toxicity of tapentadol: a systematic review.
Channell JS, Schug S
Pain Manag 2018 Sep 1;8(5):327-339. Epub 2018 Aug 6 doi: 10.2217/pmt-2018-0027. PMID: 30079795
Serotonin Syndrome in Tapentadol Literature: Systematic Review of Original Research.
Gressler LE, Hammond DA, Painter JT
J Pain Palliat Care Pharmacother 2017 Sep-Dec;31(3-4):228-236. Epub 2018 Jan 16 doi: 10.1080/15360288.2017.1416440. PMID: 29336654
Animal models of the serotonin syndrome: a systematic review.
Haberzettl R, Bert B, Fink H, Fox MA
Behav Brain Res 2013 Nov 1;256:328-45. Epub 2013 Sep 1 doi: 10.1016/j.bbr.2013.08.045. PMID: 24004848

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...