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Hypohomocysteinemia

MedGen UID:: 1611787
•Concept ID:: C4540295
•: Finding

Synonym:	Lower blood homocysteine

HPO:	HP:0020222

Definition

A decreased concentration of homocysteine in the blood. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHypohomocysteinemia

Abnormal circulating organic compound concentration
- Abnormal circulating carboxylic acid concentration
  - Abnormal circulating amino acid concentration
    - Abnormal circulating proteinogenic amino acid concentration
      - Abnormal circulating sulfur amino acid concentration
        Abnormal circulating homocysteine concentration
        Hypohomocysteinemia

Conditions with this feature

Immunodeficiency, developmental delay, and hypohomocysteinemia

MedGen UID:: 1616061
•Concept ID:: C4540293
•: Disease or Syndrome

IMDDHH is a multisystem disorder characterized by immunodeficiency, mildly delayed psychomotor development, poor overall growth from infancy, and hypohomocysteinemia. Additional features, such as congenital heart defects and liver involvement, are more variable (summary by Huppke et al., 2017).

See: Condition Record

Immunodeficiency, developmental delay, and hypohomocysteinemia

Recent clinical studies

Etiology

Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study.

Bae JB, Han JW, Song J, Lee K, Kim TH, Kwak KP, Kim BJ, Kim SG, Kim JL, Moon SW, Park JH, Ryu SH, Youn JC, Lee DY, Lee DW, Lee SB, Lee JJ, Jhoo JH, Kim KW
Clin Nutr 2021 Jul;40(7):4579-4584. Epub 2021 Jun 9 doi: 10.1016/j.clnu.2021.05.034. PMID: 34229262

Attenuation of utero-toxicity, metabolic dysfunction and inflammation by soy protein concentrate in rats exposed to fluoridated water: consequence of hyperlipidemia in parallel with hypohomocysteinemia.

Jana L, Maity PP, Perveen H, Dash M, Jana S, Dey A, De SK, Chattopadhyay S
Environ Sci Pollut Res Int 2018 Dec;25(36):36462-36473. Epub 2018 Oct 29 doi: 10.1007/s11356-018-3542-5. PMID: 30374712

Hypohomocysteinemia: a potentially treatable cause of peripheral neuropathology?

Cullen CE, Carter GT, Weiss MD, Grant PA, Saperstein DS
Phys Med Rehabil Clin N Am 2012 Feb;23(1):59-65, x. Epub 2011 Dec 14 doi: 10.1016/j.pmr.2011.11.001. PMID: 22239874

Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.

Doshi S, McDowell I, Goodfellow J, Stabler S, Boger R, Allen R, Newcombe R, Lewis M, Moat S
Metabolism 2005 Mar;54(3):351-60. doi: 10.1016/j.metabol.2004.09.015. PMID: 15736113

Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences.

Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD
Am J Kidney Dis 2003 Nov;42(5):864-81. doi: 10.1016/j.ajkd.2003.07.016. PMID: 14582032

See all (7)

Diagnosis

Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences.

Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD
Am J Kidney Dis 2003 Nov;42(5):864-81. doi: 10.1016/j.ajkd.2003.07.016. PMID: 14582032

See all (1)

Therapy

Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study.

Jana L, Maity PP, Perveen H, Dash M, Jana S, Dey A, De SK, Chattopadhyay S
Environ Sci Pollut Res Int 2018 Dec;25(36):36462-36473. Epub 2018 Oct 29 doi: 10.1007/s11356-018-3542-5. PMID: 30374712

Hypohomocysteinemia: a potentially treatable cause of peripheral neuropathology?

Cullen CE, Carter GT, Weiss MD, Grant PA, Saperstein DS
Phys Med Rehabil Clin N Am 2012 Feb;23(1):59-65, x. Epub 2011 Dec 14 doi: 10.1016/j.pmr.2011.11.001. PMID: 22239874

Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.

Doshi S, McDowell I, Goodfellow J, Stabler S, Boger R, Allen R, Newcombe R, Lewis M, Moat S
Metabolism 2005 Mar;54(3):351-60. doi: 10.1016/j.metabol.2004.09.015. PMID: 15736113

Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences.

Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD
Am J Kidney Dis 2003 Nov;42(5):864-81. doi: 10.1016/j.ajkd.2003.07.016. PMID: 14582032

See all (6)

Clinical prediction guides

Hypohomocysteinemia: a potentially treatable cause of peripheral neuropathology?

Cullen CE, Carter GT, Weiss MD, Grant PA, Saperstein DS
Phys Med Rehabil Clin N Am 2012 Feb;23(1):59-65, x. Epub 2011 Dec 14 doi: 10.1016/j.pmr.2011.11.001. PMID: 22239874

New insights into the regulation of methyl group and homocysteine metabolism.

Williams KT, Schalinske KL
J Nutr 2007 Feb;137(2):311-4. doi: 10.1093/jn/137.2.311. PMID: 17237303

See all (2)

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Hypohomocysteinemia

Definition

Term Hierarchy

Conditions with this feature

Recent clinical studies

Etiology

Diagnosis

Therapy

Clinical prediction guides

Supplemental Content

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Clinical resources

Consumer resources

Reviews

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