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Lung Non-Keratinizing Squamous Cell Carcinoma

MedGen UID:
1611891
•Concept ID:
C4526912
•
Neoplastic Process
Synonym: Non-Keratinizing Squamous Cell Lung Carcinoma

Definition

A squamous cell lung carcinoma characterized by the absence of keratinization, pearl formation, and intercellular bridges. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Non-Keratinizing Squamous Cell Carcinoma

Recent clinical studies

Etiology

Pembrolizumab-induced agranulocytosis.
Fernández Martínez V, García-Avello Fernández-Cueto A, Valencia Soto CM, Barbadillo Villanueva S, Ochagavía Sufrategui M, Rioja Carrera M, Alonso Buznego LA, Valero Domínguez M
J Oncol Pharm Pract 2024 Jun;30(4):767-771. Epub 2024 Jan 30 doi: 10.1177/10781552241228774. PMID: 38291678
Detection of a second primary cancer in a 18F-fluorocholine PET/CT - multicentre retrospective analysis on a group of 1345 prostate cancer patients.
Cegla P, Scibisz-Dziedzic K, Witkowska K, Kubiak A, Wierzchoslawska E, Kycler W, Chrapko B, Czepczyński R
Nucl Med Rev Cent East Eur 2022;25(1):25-30. doi: 10.5603/NMR.a2022.0006. PMID: 35137934
A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma.
Matsubara T, Takada K, Azuma K, Takamori S, Toyokawa G, Haro A, Osoegawa A, Tagawa T, Kawahara A, Akiba J, Okamoto I, Nakanishi Y, Oda Y, Hoshino T, Maehara Y
Ann Surg Oncol 2019 Jun;26(6):1925-1933. Epub 2019 Feb 27 doi: 10.1245/s10434-019-07257-3. PMID: 30815803
Chondrosarcoma-like metastasis from a poorly differentiated uterine cervical squamous cell carcinoma. A unique morphology and diagnostic pitfall in cytology.
Ikoma S, Nicolas M, Jagirdar J, Policarpio-Nicolas ML
Diagn Cytopathol 2017 Aug;45(8):750-753. Epub 2017 Apr 14 doi: 10.1002/dc.23721. PMID: 28411397
Ciliated Adenosquamous Carcinoma: Expanding the Phenotypic Diversity of Human Papillomavirus-Associated Tumors.
Radkay-Gonzalez L, Faquin W, McHugh JB, Lewis JS Jr, Tuluc M, Seethala RR
Head Neck Pathol 2016 Jun;10(2):167-75. Epub 2015 Sep 28 doi: 10.1007/s12105-015-0653-x. PMID: 26411881Free PMC Article

Diagnosis

Pembrolizumab-induced agranulocytosis.
Fernández Martínez V, García-Avello Fernández-Cueto A, Valencia Soto CM, Barbadillo Villanueva S, Ochagavía Sufrategui M, Rioja Carrera M, Alonso Buznego LA, Valero Domínguez M
J Oncol Pharm Pract 2024 Jun;30(4):767-771. Epub 2024 Jan 30 doi: 10.1177/10781552241228774. PMID: 38291678
Programmed death ligand-1 expression and its association with the degree of differentiation and the presence of necrosis in non-small cell lung carcinoma.
Blichárová A, Tancoš V, Benetinová Z, Verbóová Ľ, Grendár M, Mazuráková A, Plank L, Mechírová E
Pathol Res Pract 2023 Feb;242:154296. Epub 2023 Jan 4 doi: 10.1016/j.prp.2022.154296. PMID: 36610327
Malignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena.
Re A, Shersher D, Allen A, Schwarting R, Ren S
Diagn Cytopathol 2021 Jun;49(6):E234-E237. Epub 2020 Dec 21 doi: 10.1002/dc.24686. PMID: 33347735
Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.
Farkašová A, Tancoš V, Kviatkovská Z, Huťka Z, Mičák J, Scheerová K, Szépe P, Plank L
Cesk Patol 2018 Summer;54(3):137-142. PMID: 30445818
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article

Therapy

Pembrolizumab-induced agranulocytosis.
Fernández Martínez V, García-Avello Fernández-Cueto A, Valencia Soto CM, Barbadillo Villanueva S, Ochagavía Sufrategui M, Rioja Carrera M, Alonso Buznego LA, Valero Domínguez M
J Oncol Pharm Pract 2024 Jun;30(4):767-771. Epub 2024 Jan 30 doi: 10.1177/10781552241228774. PMID: 38291678
Malignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena.
Re A, Shersher D, Allen A, Schwarting R, Ren S
Diagn Cytopathol 2021 Jun;49(6):E234-E237. Epub 2020 Dec 21 doi: 10.1002/dc.24686. PMID: 33347735
ALK-rearranged squamous cell lung carcinoma responding to crizotinib: A missing link in the field of non-small cell lung cancer?
Vergne F, Quéré G, Andrieu-Key S, Descourt R, Quintin-Roué I, Talagas M, De Braekeleer M, Marcorelles P, Uguen A
Lung Cancer 2016 Jan;91:67-9. Epub 2015 Nov 10 doi: 10.1016/j.lungcan.2015.11.010. PMID: 26603857

Prognosis

Pembrolizumab-induced agranulocytosis.
Fernández Martínez V, García-Avello Fernández-Cueto A, Valencia Soto CM, Barbadillo Villanueva S, Ochagavía Sufrategui M, Rioja Carrera M, Alonso Buznego LA, Valero Domínguez M
J Oncol Pharm Pract 2024 Jun;30(4):767-771. Epub 2024 Jan 30 doi: 10.1177/10781552241228774. PMID: 38291678
A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma.
Matsubara T, Takada K, Azuma K, Takamori S, Toyokawa G, Haro A, Osoegawa A, Tagawa T, Kawahara A, Akiba J, Okamoto I, Nakanishi Y, Oda Y, Hoshino T, Maehara Y
Ann Surg Oncol 2019 Jun;26(6):1925-1933. Epub 2019 Feb 27 doi: 10.1245/s10434-019-07257-3. PMID: 30815803
Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.
Farkašová A, Tancoš V, Kviatkovská Z, Huťka Z, Mičák J, Scheerová K, Szépe P, Plank L
Cesk Patol 2018 Summer;54(3):137-142. PMID: 30445818
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas.
Xiao D, Jia J, Shi Y, Fu C, Chen L, Jiang Y, Zhou L, Liu S, Tao Y
Oncotarget 2015 Sep 22;6(28):25499-505. doi: 10.18632/oncotarget.4548. PMID: 26317791Free PMC Article

Clinical prediction guides

Programmed death ligand-1 expression and its association with the degree of differentiation and the presence of necrosis in non-small cell lung carcinoma.
Blichárová A, Tancoš V, Benetinová Z, Verbóová Ľ, Grendár M, Mazuráková A, Plank L, Mechírová E
Pathol Res Pract 2023 Feb;242:154296. Epub 2023 Jan 4 doi: 10.1016/j.prp.2022.154296. PMID: 36610327
Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature.
McHugh KE, Policarpio-Nicolas MLC
Acta Cytol 2019;63(5):431-437. Epub 2019 May 27 doi: 10.1159/000500351. PMID: 31132763
A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma.
Matsubara T, Takada K, Azuma K, Takamori S, Toyokawa G, Haro A, Osoegawa A, Tagawa T, Kawahara A, Akiba J, Okamoto I, Nakanishi Y, Oda Y, Hoshino T, Maehara Y
Ann Surg Oncol 2019 Jun;26(6):1925-1933. Epub 2019 Feb 27 doi: 10.1245/s10434-019-07257-3. PMID: 30815803
Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.
Farkašová A, Tancoš V, Kviatkovská Z, Huťka Z, Mičák J, Scheerová K, Szépe P, Plank L
Cesk Patol 2018 Summer;54(3):137-142. PMID: 30445818
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article

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