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Abnormal circulating T4 concentration

MedGen UID:
1613028
•Concept ID:
C4531080
•
Finding
Synonyms: Abnormal circulating T4 level; Abnormal circulating thyroxine level
 
HPO: HP:0031505

Definition

A deviation from the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating T4 concentration

Recent clinical studies

Etiology

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19.
Grondman I, de Nooijer AH, Antonakos N, Janssen NAF, Mouktaroudi M, Leventogiannis K, Medici M, Smit JWA, van Herwaarden AE, Joosten LAB, van de Veerdonk FL, Pickkers P, Kox M, Jaeger M, Netea MG, Giamarellos-Bourboulis EJ, Netea-Maier RT
J Clin Endocrinol Metab 2021 Jun 16;106(7):1994-2009. doi: 10.1210/clinem/dgab148. PMID: 33713408Free PMC Article
Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
Subclinical thyroid disease in elderly subjects.
Ceresini G, Morganti S, Maggio M, Usberti E, Fiorino I, Artoni A, Teresi G, Belli S, Ridolfi V, Valenti G, Ceda GP
Acta Biomed 2010;81 Suppl 1:31-6. PMID: 20518189
Thyroxine replacement therapy and circulating lipid concentrations.
Franklyn JA, Daykin J, Betteridge J, Hughes EA, Holder R, Jones SR, Sheppard MC
Clin Endocrinol (Oxf) 1993 May;38(5):453-9. doi: 10.1111/j.1365-2265.1993.tb00339.x. PMID: 8330440
Circulating lipids and minor abnormalities of thyroid function.
Parle JV, Franklyn JA, Cross KW, Jones SR, Sheppard MC
Clin Endocrinol (Oxf) 1992 Nov;37(5):411-4. doi: 10.1111/j.1365-2265.1992.tb02351.x. PMID: 1486690

Diagnosis

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19.
Grondman I, de Nooijer AH, Antonakos N, Janssen NAF, Mouktaroudi M, Leventogiannis K, Medici M, Smit JWA, van Herwaarden AE, Joosten LAB, van de Veerdonk FL, Pickkers P, Kox M, Jaeger M, Netea MG, Giamarellos-Bourboulis EJ, Netea-Maier RT
J Clin Endocrinol Metab 2021 Jun 16;106(7):1994-2009. doi: 10.1210/clinem/dgab148. PMID: 33713408Free PMC Article
Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
New insights into thyroid hormone action.
Mendoza A, Hollenberg AN
Pharmacol Ther 2017 May;173:135-145. Epub 2017 Feb 4 doi: 10.1016/j.pharmthera.2017.02.012. PMID: 28174093Free PMC Article
Subclinical thyroid disease in elderly subjects.
Ceresini G, Morganti S, Maggio M, Usberti E, Fiorino I, Artoni A, Teresi G, Belli S, Ridolfi V, Valenti G, Ceda GP
Acta Biomed 2010;81 Suppl 1:31-6. PMID: 20518189
Hyperthyroidism in the elderly.
Kawabe T, Komiya I, Endo T, Koizumi Y, Yamada T
J Am Geriatr Soc 1979 Apr;27(4):152-5. doi: 10.1111/j.1532-5415.1979.tb06438.x. PMID: 107212

Therapy

Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults.
Caron P, Grunenwald S, Persani L, Borson-Chazot F, Leroy R, Duntas L
Rev Endocr Metab Disord 2022 Jun;23(3):463-483. Epub 2021 Oct 20 doi: 10.1007/s11154-021-09691-9. PMID: 34671932Free PMC Article
Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
The thyroid--too much and too little across the ages. The consequences of subclinical thyroid dysfunction.
Franklyn JA
Clin Endocrinol (Oxf) 2013 Jan;78(1):1-8. doi: 10.1111/cen.12011. PMID: 22891671
Thyroxine replacement therapy and circulating lipid concentrations.
Franklyn JA, Daykin J, Betteridge J, Hughes EA, Holder R, Jones SR, Sheppard MC
Clin Endocrinol (Oxf) 1993 May;38(5):453-9. doi: 10.1111/j.1365-2265.1993.tb00339.x. PMID: 8330440
Thyroid function in nonthyroidal illnesses.
Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT
Ann Intern Med 1983 Jun;98(6):946-57. doi: 10.7326/0003-4819-98-6-946. PMID: 6407376

Prognosis

A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia.
Schoenmakers N, Moran C, Campi I, Agostini M, Bacon O, Rajanayagam O, Schwabe J, Bradbury S, Barrett T, Geoghegan F, Druce M, Beck-Peccoz P, O'Toole A, Clark P, Bignell M, Lyons G, Halsall D, Gurnell M, Chatterjee K
J Clin Endocrinol Metab 2014 Jul;99(7):E1381-6. Epub 2014 Mar 19 doi: 10.1210/jc.2013-4077. PMID: 24646103Free PMC Article
Expression of metallopanstimulin and oncogenesis in human prostatic carcinoma.
Fernandez-Pol JA, Fletcher JW, Hamilton PD, Klos DJ
Anticancer Res 1997 May-Jun;17(3A):1519-30. PMID: 9179190
The significance of TSH values measured in a sensitive assay in the follow-up of hyperthyroid patients treated with radioiodine.
Davies PH, Franklyn JA, Daykin J, Sheppard MC
J Clin Endocrinol Metab 1992 May;74(5):1189-94. doi: 10.1210/jcem.74.5.1569166. PMID: 1569166
Thyroid function and abdominal surgery. A longitudinal study.
Halabe Cherem J, Nellen Hummel H, Gordon Barabejski F, Chong Martínez BA, Lifshitz Guinzberg A
Arch Med Res 1992 Autumn;23(3):143-7. PMID: 1308805
Thyroid function in nonthyroidal illnesses.
Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT
Ann Intern Med 1983 Jun;98(6):946-57. doi: 10.7326/0003-4819-98-6-946. PMID: 6407376

Clinical prediction guides

Central hypothyroidism - a neglected thyroid disorder.
Beck-Peccoz P, Rodari G, Giavoli C, Lania A
Nat Rev Endocrinol 2017 Oct;13(10):588-598. Epub 2017 May 26 doi: 10.1038/nrendo.2017.47. PMID: 28549061
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia.
Schoenmakers N, Moran C, Campi I, Agostini M, Bacon O, Rajanayagam O, Schwabe J, Bradbury S, Barrett T, Geoghegan F, Druce M, Beck-Peccoz P, O'Toole A, Clark P, Bignell M, Lyons G, Halsall D, Gurnell M, Chatterjee K
J Clin Endocrinol Metab 2014 Jul;99(7):E1381-6. Epub 2014 Mar 19 doi: 10.1210/jc.2013-4077. PMID: 24646103Free PMC Article
Thyroid hormones and fetal neurological development.
Patel J, Landers K, Li H, Mortimer RH, Richard K
J Endocrinol 2011 Apr;209(1):1-8. Epub 2011 Jan 6 doi: 10.1530/JOE-10-0444. PMID: 21212091
Are thyroid function tests too frequently and inappropriately requested?
Roti E, Gardini E, Magotti MG, Pilla S, Minelli R, Salvi M, Monica C, Maestri D, Cencetti S, Braverman LE
J Endocrinol Invest 1999 Mar;22(3):184-90. doi: 10.1007/BF03343539. PMID: 10219885
Circulating lipids and minor abnormalities of thyroid function.
Parle JV, Franklyn JA, Cross KW, Jones SR, Sheppard MC
Clin Endocrinol (Oxf) 1992 Nov;37(5):411-4. doi: 10.1111/j.1365-2265.1992.tb02351.x. PMID: 1486690

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