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Subretinal deposits

MedGen UID:: 1613321
•Concept ID:: C4531024
•: Finding

HPO:	HP:0031528

Definition

Deposits accumulating between the outer retina and the retinal pigment epithelium. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSubretinal deposits

Phenotypic abnormality
- Abnormality of the eye
  - Abnormal eye morphology
    - Abnormal posterior eye segment morphology
      - Abnormal fundus morphology
        Abnormal retinal morphology
        Subretinal deposits
        Focal subretinal deposits
        Multifocal subretinal deposits

Conditions with this feature

Congenital hypotrichosis with juvenile macular dystrophy

MedGen UID:: 316921
•Concept ID:: C1832162
•: Disease or Syndrome

Hypotrichosis with juvenile macular degeneration (HJMD) is a very rare syndrome characterized by sparse and short hair from birth followed by progressive macular degeneration leading to blindness.

See: Condition Record

Congenital hypotrichosis with juvenile macular dystrophy

Professional guidelines

PubMed

Treatment Strategy With Gene Editing for Late-Onset Retinal Degeneration Caused by a Founder Variant in C1QTNF5.

Li RTH, Roman AJ, Sumaroka A, Stanton CM, Swider M, Garafalo AV, Heon E, Vincent A, Wright AF, Megaw R, Aleman TS, Browning AC, Dhillon B, Cideciyan AV
Invest Ophthalmol Vis Sci 2023 Dec 1;64(15):33. doi: 10.1167/iovs.64.15.33. PMID: 38133503 Free PMC Article

Autosomal recessive bestrophinopathy: differential diagnosis and treatment options.

Boon CJ, van den Born LI, Visser L, Keunen JE, Bergen AA, Booij JC, Riemslag FC, Florijn RJ, van Schooneveld MJ
Ophthalmology 2013 Apr;120(4):809-20. Epub 2013 Jan 3 doi: 10.1016/j.ophtha.2012.09.057. PMID: 23290749

See all (2)

Recent clinical studies

Etiology

Mitochondrial Retinopathy.

Birtel J, von Landenberg C, Gliem M, Gliem C, Reimann J, Kunz WS, Herrmann P, Betz C, Caswell R, Nesbitt V, Kornblum C, Charbel Issa P
Ophthalmol Retina 2022 Jan;6(1):65-79. Epub 2021 Jul 10 doi: 10.1016/j.oret.2021.02.017. PMID: 34257060

Subretinal Deposits in Pre-eclampsia and Malignant Hypertension: Implications for Age-Related Macular Degeneration.

Otero-Marquez O, Chung H, Lee CS, Choi EY, Ledesma-Gil G, Alauddin S, Lee M, Bhuiyan A, Smith RT
Ophthalmol Retina 2021 Aug;5(8):750-760. Epub 2020 Oct 28 doi: 10.1016/j.oret.2020.10.018. PMID: 33130003

Gender variation in central serous chorioretinopathy.

Hanumunthadu D, Van Dijk EHC, Gangakhedkar S, Goud A, Cheung CMG, Cherfan D, Sarvaiya C, Banker A, Meyerle C, Boon CJ, Singh R, Wu L, Chhablani J
Eye (Lond) 2018 Nov;32(11):1703-1709. Epub 2018 Jul 9 doi: 10.1038/s41433-018-0163-7. PMID: 29988073 Free PMC Article

Paraproteinemic maculopathy.

Mansour AM, Arevalo JF, Badal J, Moorthy RS, Shah GK, Zegarra H, Pulido JS, Charbaji A, Amselem L, Lavaque AJ, Casella A, Ahmad B, Paschall JG, Caimi A, Staurenghi G
Ophthalmology 2014 Oct;121(10):1925-32. Epub 2014 Jun 18 doi: 10.1016/j.ophtha.2014.04.007. PMID: 24950591

Reticular pseudodrusen in age-related macular degeneration.

Hogg RE
Optom Vis Sci 2014 Aug;91(8):854-9. doi: 10.1097/OPX.0000000000000287. PMID: 24950032

See all (44)

Diagnosis

Subretinal autofluorescent deposits: A review and proposal for clinical classification.

Cohen SY, Chowers I, Nghiem-Buffet S, Mrejen S, Souied E, Gaudric A
Surv Ophthalmol 2023 Nov-Dec;68(6):1050-1070. Epub 2023 Jun 29 doi: 10.1016/j.survophthal.2023.06.009. PMID: 37392968

Subretinal Deposits Associated With Type 1 Cryoglobulinemia.

Chen H, Zhang Y, Dai R
JAMA Ophthalmol 2023 May 1;141(5):e230082. Epub 2023 May 18 doi: 10.1001/jamaophthalmol.2023.0082. PMID: 37199811

Mitochondrial Retinopathy.

MULTIMODAL IMAGING IN HELLP-RELATED CHORIORETINOPATHY.

Van Rysselberge C, Balikova I, Judice L, Makhoul D, Postelmans L
Retin Cases Brief Rep 2022 May 1;16(3):333-337. Epub 2020 Feb 4 doi: 10.1097/ICB.0000000000000970. PMID: 32028449

Subretinal Deposits in Pre-eclampsia and Malignant Hypertension: Implications for Age-Related Macular Degeneration.

See all (63)

Therapy

Unusual presentation of cornea verticillata with intravitreal methotrexate in a case of primary intraocular lymphoma.

Hasan N, Narde HK, Das AK, Chawla R
BMJ Case Rep 2022 Jan 13;15(1) doi: 10.1136/bcr-2021-246911. PMID: 35027386 Free PMC Article

Yellow Subretinal Lesions following Initiation of Antituberculosis Therapy in A Tubercular Choroidal Granuloma: A Sign of Paradoxical Worsening?

Arora A, Katoch D, Jain S, Singh SR, Gupta V
Ocul Immunol Inflamm 2022 Jan 2;30(1):29-33. Epub 2020 Aug 12 doi: 10.1080/09273948.2020.1780272. PMID: 32783681

Eplerenone in patients with chronic recurring central serous chorioretinopathy.

Leisser C, Hirnschall N, Hackl C, Plasenzotti P, Findl O
Eur J Ophthalmol 2016 Aug 4;26(5):479-84. Epub 2015 Dec 17 doi: 10.5301/ejo.5000727. PMID: 26692062

Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice.

Nakayama M, Iejima D, Akahori M, Kamei J, Goto A, Iwata T
Invest Ophthalmol Vis Sci 2014 Sep 9;55(10):6514-23. doi: 10.1167/iovs.14-14453. PMID: 25205867

Foveal function and thickness after verteporfin photodynamic therapy in central serous chorioretinopathy with hyperautofluorescent subretinal deposits.

Pryds A, Larsen M
Retina 2013 Jan;33(1):128-35. doi: 10.1097/IAE.0b013e3182618bc5. PMID: 23269407

See all (13)

Prognosis

Subretinal Deposits in Pre-eclampsia and Malignant Hypertension: Implications for Age-Related Macular Degeneration.

SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES OF VITREORETINAL LYMPHOMA IN 55 EYES.

Yang X, Dalvin LA, Mazloumi M, Ferenczy S, Lim LS, Ancona-Lezama D, Shields JA, Mashayekhi A, Shields CL
Retina 2021 Feb 1;41(2):249-258. doi: 10.1097/IAE.0000000000002819. PMID: 32349103

HYPERREFLECTIVE DEPOSITION IN THE BACKGROUND OF ADVANCED STARGARDT DISEASE.

Ciccone L, Lee W, Zernant J, Tanaka K, Schuerch K, Tsang SH, Allikmets R
Retina 2018 Nov;38(11):2214-2219. doi: 10.1097/IAE.0000000000001841. PMID: 29028687 Free PMC Article

Paraproteinemic maculopathy.

Reticular pseudodrusen in age-related macular degeneration.

Hogg RE
Optom Vis Sci 2014 Aug;91(8):854-9. doi: 10.1097/OPX.0000000000000287. PMID: 24950032

See all (22)

Clinical prediction guides

Subretinal autofluorescent deposits: A review and proposal for clinical classification.

Cohen SY, Chowers I, Nghiem-Buffet S, Mrejen S, Souied E, Gaudric A
Surv Ophthalmol 2023 Nov-Dec;68(6):1050-1070. Epub 2023 Jun 29 doi: 10.1016/j.survophthal.2023.06.009. PMID: 37392968

Subretinal Deposits in Pre-eclampsia and Malignant Hypertension: Implications for Age-Related Macular Degeneration.

SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES OF VITREORETINAL LYMPHOMA IN 55 EYES.

Yang X, Dalvin LA, Mazloumi M, Ferenczy S, Lim LS, Ancona-Lezama D, Shields JA, Mashayekhi A, Shields CL
Retina 2021 Feb 1;41(2):249-258. doi: 10.1097/IAE.0000000000002819. PMID: 32349103

Paraproteinemic maculopathy.

Reticular pseudodrusen in age-related macular degeneration.

Hogg RE
Optom Vis Sci 2014 Aug;91(8):854-9. doi: 10.1097/OPX.0000000000000287. PMID: 24950032

See all (42)

MedGen

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Subretinal deposits

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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