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Unresectable Head and Neck Squamous Cell Carcinoma

MedGen UID:
1613385
•Concept ID:
C4526673
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the head and neck region and is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Efficacy and feasibility of induction chemotherapy with paclitaxel, carboplatin and cetuximab for locally advanced unresectable head and neck cancer patients ineligible for combination treatment with docetaxel, cisplatin, and 5-fluorouracil.
Shirasu H, Yokota T, Kawakami T, Hamauchi S, Onozawa Y, Ogawa H, Onoe T, Mori K, Onitsuka T
Int J Clin Oncol 2020 Nov;25(11):1914-1920. Epub 2020 Jul 9 doi: 10.1007/s10147-020-01742-6. PMID: 32648132
AHNS Series: Do you know your guidelines? Principles of treatment for locally advanced or unresectable head and neck squamous cell carcinoma.
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article

Recent clinical studies

Etiology

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome.
Leu M, Kitz J, Pilavakis Y, Hakroush S, Wolff HA, Canis M, Rieken S, Schirmer MA
Sci Rep 2021 Feb 25;11(1):4578. doi: 10.1038/s41598-021-84019-w. PMID: 33633176Free PMC Article
AHNS Series: Do you know your guidelines? Principles of treatment for locally advanced or unresectable head and neck squamous cell carcinoma.
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: a subset analysis of EORTC 24971 study.
Psyrri A, Fortpied C, Koutsodontis G, Avgeris M, Kroupis C, Goutas N, Menis J, Herman L, Giurgea L, Remenár É, Degardin M, Pateras IS, Langendijk JA, van Herpen CML, Awada A, Germà-Lluch JR, Kienzer HR, Licitra L, Vermorken JB
Ann Oncol 2017 Sep 1;28(9):2213-2218. doi: 10.1093/annonc/mdx320. PMID: 28651338
High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area.
Chiu TJ, Chen CH, Chien CY, Li SH, Tsai HT, Chen YJ
J Transl Med 2011 Mar 23;9:31. doi: 10.1186/1479-5876-9-31. PMID: 21426588Free PMC Article
High-dose cisplatin concurrent to conventionally delivered radiotherapy is associated with unacceptable toxicity in unresectable, non-metastatic stage IV head and neck squamous cell carcinoma.
de Castro G Jr, Snitcovsky IM, Gebrim EM, Leitão GM, Nadalin W, Ferraz AR, Federico MH
Eur Arch Otorhinolaryngol 2007 Dec;264(12):1475-82. Epub 2007 Jul 21 doi: 10.1007/s00405-007-0395-9. PMID: 17643256

Diagnosis

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome.
Leu M, Kitz J, Pilavakis Y, Hakroush S, Wolff HA, Canis M, Rieken S, Schirmer MA
Sci Rep 2021 Feb 25;11(1):4578. doi: 10.1038/s41598-021-84019-w. PMID: 33633176Free PMC Article
AHNS Series: Do you know your guidelines? Principles of treatment for locally advanced or unresectable head and neck squamous cell carcinoma.
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.
Nakahara S, Takenaka Y, Ogawa K, Nishiike S, Yamamoto Y, Seo Y, Isohashi F, Suzuki O, Yoshioka Y, Sumida I, Yoshii T, Tomiyama Y, Inohara H
Int J Clin Oncol 2016 Dec;21(6):1030-1037. Epub 2016 Jun 15 doi: 10.1007/s10147-016-0997-6. PMID: 27306220
The predictive value of tumor regression rates during chemoradiation therapy in patients with advanced head and neck squamous cell carcinoma.
Denys D, Kumar P, Wong FS, Newman LA, Robbins KT
Am J Surg 1997 Nov;174(5):561-4. doi: 10.1016/s0002-9610(97)00147-5. PMID: 9374238

Therapy

A Network Meta-Analysis of the Systemic Therapies in Unresectable Head and Neck Squamous Cell Carcinoma.
Yuan J, Shi K, Chen G, Xu W, Qiu L, Fei Y, Zhu Y, Wu M, Li Y, Sun X, Cao Y, Zhou S
Cancer Control 2024 Jan-Dec;31:10732748241255535. doi: 10.1177/10732748241255535. PMID: 38773761Free PMC Article
Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: a subset analysis of EORTC 24971 study.
Psyrri A, Fortpied C, Koutsodontis G, Avgeris M, Kroupis C, Goutas N, Menis J, Herman L, Giurgea L, Remenár É, Degardin M, Pateras IS, Langendijk JA, van Herpen CML, Awada A, Germà-Lluch JR, Kienzer HR, Licitra L, Vermorken JB
Ann Oncol 2017 Sep 1;28(9):2213-2218. doi: 10.1093/annonc/mdx320. PMID: 28651338
Intra-arterial cetuximab for the treatment of recurrent unresectable head and neck squamous cell carcinoma(†).
Tham T, White TG, Chakraborty S, Lall RR, Ortiz R, Langer DJ, Shatzkes D, Filippi CG, Kraus D, Boockvar JA, Costantino PD
J Exp Ther Oncol 2016 Nov;11(4):293-301. PMID: 27849340
Efficacy of brachytherapy concomitant with chemotherapy with docetaxel, cisplatin, and 5-fluorouracil in unresectable head and neck squamous cell carcinoma.
Wang X, Meng J
J BUON 2016 May-Jun;21(3):588-93. PMID: 27569077
Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.
Nakahara S, Takenaka Y, Ogawa K, Nishiike S, Yamamoto Y, Seo Y, Isohashi F, Suzuki O, Yoshioka Y, Sumida I, Yoshii T, Tomiyama Y, Inohara H
Int J Clin Oncol 2016 Dec;21(6):1030-1037. Epub 2016 Jun 15 doi: 10.1007/s10147-016-0997-6. PMID: 27306220

Prognosis

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome.
Leu M, Kitz J, Pilavakis Y, Hakroush S, Wolff HA, Canis M, Rieken S, Schirmer MA
Sci Rep 2021 Feb 25;11(1):4578. doi: 10.1038/s41598-021-84019-w. PMID: 33633176Free PMC Article
AHNS Series: Do you know your guidelines? Principles of treatment for locally advanced or unresectable head and neck squamous cell carcinoma.
Fulcher CD, Haigentz M Jr, Ow TJ; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2018 Apr;40(4):676-686. Epub 2017 Nov 24 doi: 10.1002/hed.25025. PMID: 29171929Free PMC Article
Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: a subset analysis of EORTC 24971 study.
Psyrri A, Fortpied C, Koutsodontis G, Avgeris M, Kroupis C, Goutas N, Menis J, Herman L, Giurgea L, Remenár É, Degardin M, Pateras IS, Langendijk JA, van Herpen CML, Awada A, Germà-Lluch JR, Kienzer HR, Licitra L, Vermorken JB
Ann Oncol 2017 Sep 1;28(9):2213-2218. doi: 10.1093/annonc/mdx320. PMID: 28651338
High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area.
Chiu TJ, Chen CH, Chien CY, Li SH, Tsai HT, Chen YJ
J Transl Med 2011 Mar 23;9:31. doi: 10.1186/1479-5876-9-31. PMID: 21426588Free PMC Article
Quality-of-life assessment after hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and paclitaxel (Taxol) in inoperable and/or unresectable head and neck squamous cell carcinoma.
Abdel-Wahab M, Abitbol A, Lewin A, Troner M, Hamilton K, Markoe A
Am J Clin Oncol 2005 Aug;28(4):359-66. doi: 10.1097/01.coc.0000158837.47450.81. PMID: 16062077

Clinical prediction guides

Efficacy and feasibility of induction chemotherapy with paclitaxel, carboplatin and cetuximab for locally advanced unresectable head and neck cancer patients ineligible for combination treatment with docetaxel, cisplatin, and 5-fluorouracil.
Shirasu H, Yokota T, Kawakami T, Hamauchi S, Onozawa Y, Ogawa H, Onoe T, Mori K, Onitsuka T
Int J Clin Oncol 2020 Nov;25(11):1914-1920. Epub 2020 Jul 9 doi: 10.1007/s10147-020-01742-6. PMID: 32648132
Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: a subset analysis of EORTC 24971 study.
Psyrri A, Fortpied C, Koutsodontis G, Avgeris M, Kroupis C, Goutas N, Menis J, Herman L, Giurgea L, Remenár É, Degardin M, Pateras IS, Langendijk JA, van Herpen CML, Awada A, Germà-Lluch JR, Kienzer HR, Licitra L, Vermorken JB
Ann Oncol 2017 Sep 1;28(9):2213-2218. doi: 10.1093/annonc/mdx320. PMID: 28651338
Induction chemotherapy with dose-modified docetaxel, cisplatin, and 5-fluorouracil in Asian patients with borderline resectable or unresectable head and neck cancer.
Wang HM, Lin CY, Hsieh CH, Hsu CL, Fan KH, Chang JT, Huang SF, Kang CJ, Liao CT, Ng SH, Yen TC
J Formos Med Assoc 2017 Mar;116(3):185-192. Epub 2016 Apr 25 doi: 10.1016/j.jfma.2016.03.005. PMID: 27133181
High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area.
Chiu TJ, Chen CH, Chien CY, Li SH, Tsai HT, Chen YJ
J Transl Med 2011 Mar 23;9:31. doi: 10.1186/1479-5876-9-31. PMID: 21426588Free PMC Article
Phase II trial of gemcitabine concurrent with radiation for locally advanced squamous cell carcinoma of the head and neck.
Aguilar-Ponce J, Granados-García M, Villavicencio V, Poitevin-Chacón A, Green D, Dueñas-González A, Herrera-Gómez A, Luna-Ortiz K, Alvarado A, Martínez-Said H, Castillo-Henkel C, Segura-Pacheco B, De la Garza J
Ann Oncol 2004 Feb;15(2):301-6. doi: 10.1093/annonc/mdh071. PMID: 14760126

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