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Abnormal glomerular visceral epithelial cell morphology

MedGen UID:
1614621
•Concept ID:
C4531238
•
Finding
Synonyms: Abnormal podocyte morphology; Abnormal visceral epithelial cell morphology
 
HPO: HP:0031265

Definition

Any structural anomaly of the podocyte, which is a highly specialized cell of the Bowman capsule and which forms multiple interdigitating foot processes. Podocytes are interconnected by slit diaphragms and cover the exterior basement membrane surface of the glomerular capillary. [from HPO]

Professional guidelines

PubMed

Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease.
Petrazzuolo A, Sabiu G, Assi E, Maestroni A, Pastore I, Lunati ME, Montefusco L, Loretelli C, Rossi G, Ben Nasr M, Usuelli V, Xie Y, Balasubramanian HB, Zocchi M, El Essawy B, Yang J, D'Addio F, Fiorina P
Pharmacol Res 2023 Apr;190:106710. Epub 2023 Mar 4 doi: 10.1016/j.phrs.2023.106710. PMID: 36871895
Integration of Genetic Testing and Pathology for the Diagnosis of Adults with FSGS.
Yao T, Udwan K, John R, Rana A, Haghighi A, Xu L, Hack S, Reich HN, Hladunewich MA, Cattran DC, Paterson AD, Pei Y, Barua M
Clin J Am Soc Nephrol 2019 Feb 7;14(2):213-223. Epub 2019 Jan 15 doi: 10.2215/CJN.08750718. PMID: 30647093Free PMC Article
Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nat Genet 2017 Oct;49(10):1529-1538. Epub 2017 Aug 14 doi: 10.1038/ng.3933. PMID: 28805828Free PMC Article

Recent clinical studies

Etiology

Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors.
Guo W, Li H, Li Y, Kong W
Biomed Pharmacother 2023 Sep;165:115025. Epub 2023 Jun 28 doi: 10.1016/j.biopha.2023.115025. PMID: 37385209
Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants.
Menon R, Otto EA, Berthier CC, Nair V, Farkash EA, Hodgin JB, Yang Y, Luo J, Woodside KJ, Zamani H, Norman SP, Wiggins RC, Kretzler M, Naik AS
Kidney Int 2022 Apr;101(4):779-792. Epub 2021 Dec 22 doi: 10.1016/j.kint.2021.11.031. PMID: 34952098Free PMC Article
ApoL1 induces kidney inflammation through RIG-I/NF-κB activation.
Fang J, Yao X, Hou M, Duan M, Xing L, Huang J, Wang Y, Zhu B, Chen Q, Wang H
Biochem Biophys Res Commun 2020 Jun 25;527(2):466-473. Epub 2020 Apr 24 doi: 10.1016/j.bbrc.2020.04.054. PMID: 32336543
Alport syndrome--insights from basic and clinical research.
Kruegel J, Rubel D, Gross O
Nat Rev Nephrol 2013 Mar;9(3):170-8. Epub 2012 Nov 20 doi: 10.1038/nrneph.2012.259. PMID: 23165304
Update in podocyte biology: putting one's best foot forward.
Barisoni L, Kopp JB
Curr Opin Nephrol Hypertens 2003 May;12(3):251-8. doi: 10.1097/00041552-200305000-00005. PMID: 12698062

Diagnosis

Role of sirtuins in metabolic disease-related renal injury.
Chen HH, Zhang YX, Lv JL, Liu YY, Guo JY, Zhao L, Nan YX, Wu QJ, Zhao YH
Biomed Pharmacother 2023 May;161:114417. Epub 2023 Feb 20 doi: 10.1016/j.biopha.2023.114417. PMID: 36812714
Developmental disorder of podocytes and the related renal diseases.
Zhu YN, Ao Y, Li B, Wan Y, Wang H
Yi Chuan 2018 Feb 20;40(2):116-125. doi: 10.16288/j.yczz.17-221. PMID: 29428904
Sirtuin and metabolic kidney disease.
Wakino S, Hasegawa K, Itoh H
Kidney Int 2015 Oct;88(4):691-8. Epub 2015 Jun 17 doi: 10.1038/ki.2015.157. PMID: 26083654Free PMC Article
Alport syndrome--insights from basic and clinical research.
Kruegel J, Rubel D, Gross O
Nat Rev Nephrol 2013 Mar;9(3):170-8. Epub 2012 Nov 20 doi: 10.1038/nrneph.2012.259. PMID: 23165304
Podocyte biology and the emerging understanding of podocyte diseases.
Barisoni L, Mundel P
Am J Nephrol 2003 Sep-Oct;23(5):353-60. Epub 2003 Aug 12 doi: 10.1159/000072917. PMID: 12915777

Therapy

Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors.
Guo W, Li H, Li Y, Kong W
Biomed Pharmacother 2023 Sep;165:115025. Epub 2023 Jun 28 doi: 10.1016/j.biopha.2023.115025. PMID: 37385209
Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants.
Menon R, Otto EA, Berthier CC, Nair V, Farkash EA, Hodgin JB, Yang Y, Luo J, Woodside KJ, Zamani H, Norman SP, Wiggins RC, Kretzler M, Naik AS
Kidney Int 2022 Apr;101(4):779-792. Epub 2021 Dec 22 doi: 10.1016/j.kint.2021.11.031. PMID: 34952098Free PMC Article
Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.
DeFronzo RA, Reeves WB, Awad AS
Nat Rev Nephrol 2021 May;17(5):319-334. Epub 2021 Feb 5 doi: 10.1038/s41581-021-00393-8. PMID: 33547417
Connexin 43: a New Therapeutic Target Against Chronic Kidney Disease.
Prakoura N, Kavvadas P, Chadjichristos CE
Cell Physiol Biochem 2018;49(3):985. Epub 2018 Sep 7 doi: 10.1159/000493230. PMID: 30196298
Sirtuin and metabolic kidney disease.
Wakino S, Hasegawa K, Itoh H
Kidney Int 2015 Oct;88(4):691-8. Epub 2015 Jun 17 doi: 10.1038/ki.2015.157. PMID: 26083654Free PMC Article

Prognosis

Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.
Caza T, Wijewardena C, Al-Rabadi L, Perl A
Transl Res 2022 Jul;245:55-81. Epub 2022 Mar 12 doi: 10.1016/j.trsl.2022.03.004. PMID: 35288362Free PMC Article
Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome.
Mann N, Mzoughi S, Schneider R, Kühl SJ, Schanze D, Klämbt V, Lovric S, Mao Y, Shi S, Tan W, Kühl M, Onuchic-Whitford AC, Treimer E, Kitzler TM, Kause F, Schumann S, Nakayama M, Buerger F, Shril S, van der Ven AT, Majmundar AJ, Holton KM, Kolb A, Braun DA, Rao J, Jobst-Schwan T, Mildenberger E, Lennert T, Kuechler A, Wieczorek D, Gross O, Ermisch-Omran B, Werberger A, Skalej M, Janecke AR, Soliman NA, Mane SM, Lifton RP, Kadlec J, Guccione E, Schmeisser MJ, Zenker M, Hildebrandt F
J Am Soc Nephrol 2021 Mar;32(3):580-596. Epub 2021 Feb 16 doi: 10.1681/ASN.2020040490. PMID: 33593823Free PMC Article
Podocytopathies.
Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, Romagnani P
Nat Rev Dis Primers 2020 Aug 13;6(1):68. doi: 10.1038/s41572-020-0196-7. PMID: 32792490Free PMC Article
Nail-patella syndrome.
Witzgall R
Pflugers Arch 2017 Aug;469(7-8):927-936. Epub 2017 Jul 5 doi: 10.1007/s00424-017-2013-z. PMID: 28681095
Pathophysiology of proteinuria.
D'Amico G, Bazzi C
Kidney Int 2003 Mar;63(3):809-25. doi: 10.1046/j.1523-1755.2003.00840.x. PMID: 12631062

Clinical prediction guides

Mesangial Injury and Capillary Ballooning Precede Podocyte Damage in Nephrosclerosis.
Kriz W, Wiech T, Gröne HJ
Am J Pathol 2022 Dec;192(12):1670-1682. Epub 2022 Sep 21 doi: 10.1016/j.ajpath.2022.08.007. PMID: 36150506
Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.
Caza T, Wijewardena C, Al-Rabadi L, Perl A
Transl Res 2022 Jul;245:55-81. Epub 2022 Mar 12 doi: 10.1016/j.trsl.2022.03.004. PMID: 35288362Free PMC Article
The Players: Cells Involved in Glomerular Disease.
Kitching AR, Hutton HL
Clin J Am Soc Nephrol 2016 Sep 7;11(9):1664-1674. Epub 2016 Apr 12 doi: 10.2215/CJN.13791215. PMID: 27073196Free PMC Article
Immunopathogenesis of idiopathic nephrotic syndrome with relapse.
Sahali D, Sendeyo K, Mangier M, Audard V, Zhang SY, Lang P, Ollero M, Pawlak A
Semin Immunopathol 2014 Jul;36(4):421-9. Epub 2014 Jan 9 doi: 10.1007/s00281-013-0415-3. PMID: 24402710Free PMC Article
Pathophysiology of proteinuria.
D'Amico G, Bazzi C
Kidney Int 2003 Mar;63(3):809-25. doi: 10.1046/j.1523-1755.2003.00840.x. PMID: 12631062

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