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BCL6 Gene Translocation

MedGen UID:
1616516
•Concept ID:
C4525462
•
Cell or Molecular Dysfunction
Synonyms: B-Cell CLL/Lymphoma 6 Gene Translocation; Bcl-6 Gene Translocation; BCL5 Gene Translocation; BCL6 Translocation; LAZ3 Gene Translocation; ZBTB27 Gene Translocation; Zinc Finger Protein 51 Gene Translocation; ZNF51 Gene Translocation

Definition

A cytogenetic abnormality that refers to any translocation involving the BCL6 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBCL6 Gene Translocation

Professional guidelines

PubMed

An analysis of genetic targets for guiding clinical management of follicular lymphoma.
Alonso-Alonso R, Rodriguez M, Morillo D, Cordoba R, Piris MA
Expert Rev Hematol 2020 Dec;13(12):1361-1372. Epub 2020 Dec 4 doi: 10.1080/17474086.2020.1850252. PMID: 33176509
Targetable genetic features of primary testicular and primary central nervous system lymphomas.
Chapuy B, Roemer MG, Stewart C, Tan Y, Abo RP, Zhang L, Dunford AJ, Meredith DM, Thorner AR, Jordanova ES, Liu G, Feuerhake F, Ducar MD, Illerhaus G, Gusenleitner D, Linden EA, Sun HH, Homer H, Aono M, Pinkus GS, Ligon AH, Ligon KL, Ferry JA, Freeman GJ, van Hummelen P, Golub TR, Getz G, Rodig SJ, de Jong D, Monti S, Shipp MA
Blood 2016 Feb 18;127(7):869-81. Epub 2015 Dec 23 doi: 10.1182/blood-2015-10-673236. PMID: 26702065Free PMC Article
MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management.
Cai Q, Medeiros LJ, Xu X, Young KH
Oncotarget 2015 Nov 17;6(36):38591-616. doi: 10.18632/oncotarget.5774. PMID: 26416427Free PMC Article

Recent clinical studies

Etiology

Clinicopathologic characterization of diffuse-large-B-cell lymphoma with an associated serum monoclonal IgM component.
Cox MC, Di Napoli A, Scarpino S, Salerno G, Tatarelli C, Talerico C, Lombardi M, Monarca B, Amadori S, Ruco L
PLoS One 2014;9(4):e93903. Epub 2014 Apr 4 doi: 10.1371/journal.pone.0093903. PMID: 24705344Free PMC Article
BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.
Akasaka T, Lossos IS, Levy R
Blood 2003 Aug 15;102(4):1443-8. Epub 2003 May 8 doi: 10.1182/blood-2002-08-2482. PMID: 12738680

Diagnosis

BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.
Akasaka T, Lossos IS, Levy R
Blood 2003 Aug 15;102(4):1443-8. Epub 2003 May 8 doi: 10.1182/blood-2002-08-2482. PMID: 12738680

Therapy

Clinicopathologic characterization of diffuse-large-B-cell lymphoma with an associated serum monoclonal IgM component.
Cox MC, Di Napoli A, Scarpino S, Salerno G, Tatarelli C, Talerico C, Lombardi M, Monarca B, Amadori S, Ruco L
PLoS One 2014;9(4):e93903. Epub 2014 Apr 4 doi: 10.1371/journal.pone.0093903. PMID: 24705344Free PMC Article

Prognosis

Clinicopathologic characterization of diffuse-large-B-cell lymphoma with an associated serum monoclonal IgM component.
Cox MC, Di Napoli A, Scarpino S, Salerno G, Tatarelli C, Talerico C, Lombardi M, Monarca B, Amadori S, Ruco L
PLoS One 2014;9(4):e93903. Epub 2014 Apr 4 doi: 10.1371/journal.pone.0093903. PMID: 24705344Free PMC Article
The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene.
Lossos IS, Akasaka T, Martinez-Climent JA, Siebert R, Levy R
Leukemia 2003 Jul;17(7):1390-7. doi: 10.1038/sj.leu.2402997. PMID: 12835729
BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.
Akasaka T, Lossos IS, Levy R
Blood 2003 Aug 15;102(4):1443-8. Epub 2003 May 8 doi: 10.1182/blood-2002-08-2482. PMID: 12738680

Clinical prediction guides

Clinicopathologic characterization of diffuse-large-B-cell lymphoma with an associated serum monoclonal IgM component.
Cox MC, Di Napoli A, Scarpino S, Salerno G, Tatarelli C, Talerico C, Lombardi M, Monarca B, Amadori S, Ruco L
PLoS One 2014;9(4):e93903. Epub 2014 Apr 4 doi: 10.1371/journal.pone.0093903. PMID: 24705344Free PMC Article
The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene.
Lossos IS, Akasaka T, Martinez-Climent JA, Siebert R, Levy R
Leukemia 2003 Jul;17(7):1390-7. doi: 10.1038/sj.leu.2402997. PMID: 12835729
BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.
Akasaka T, Lossos IS, Levy R
Blood 2003 Aug 15;102(4):1443-8. Epub 2003 May 8 doi: 10.1182/blood-2002-08-2482. PMID: 12738680

Supplemental Content

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