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Extrafoveal choroidal neovascularization

MedGen UID:
1620659
•Concept ID:
C4531253
•
Pathologic Function
Synonym: Extrafoveal choroidal neovascular membrane
SNOMED CT: Extrafoveal choroidal neovascular membrane (1231273008); Extrafoveal choroidal neovascularization (1231273008)
 
HPO: HP:0031239

Definition

A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 200 to 1500 micrometers from the center of the fovea. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrafoveal choroidal neovascularization

Professional guidelines

PubMed

Does laser still have a role in the management of retinal vascular and neovascular diseases?
Shah AM, Bressler NM, Jampol LM
Am J Ophthalmol 2011 Sep;152(3):332-339.e1. Epub 2011 Jul 13 doi: 10.1016/j.ajo.2011.04.015. PMID: 21742309
Treatment of juxtafoveal and extrafoveal choroidal neovascularization in the era of photodynamic therapy with verteporfin.
Jampol LM, Scott L
Am J Ophthalmol 2002 Jul;134(1):99-101. doi: 10.1016/s0002-9394(02)01463-0. PMID: 12095815
Important points in management of patients with choroidal neovascularization.
Singerman LJ
Ophthalmology 1985 May;92(5):610-4. doi: 10.1016/s0161-6420(85)33994-5. PMID: 2409503

Recent clinical studies

Etiology

Intravitreal ranibizumab for naive extrafoveal choroidal neovascularization secondary to age-related macular degeneration.
Parodi MB, Iacono P, La Spina C, Iuliano L, Lo Giudice G, Introini U, Bandello F
Retina 2014 Nov;34(11):2167-70. doi: 10.1097/IAE.0000000000000223. PMID: 24999724
Intravitreal bevacizumab for extrafoveal choroidal neovascularization secondary to pathologic myopia.
Parodi MB, Iacono P, Papayannis A, Kontadakis S, Cascavilla ML, Zucchiatti I, Bandello F
Retina 2013 Mar;33(3):593-7. doi: 10.1097/IAE.0b013e31826b6731. PMID: 23190919
CME review: A cost-utility analysis of laser photocoagulation for extrafoveal choroidal neovascularization.
Busbee BG, Brown MM, Brown GC, Sharma S
Retina 2003 Jun;23(3):279-87; ; quiz 443-4. doi: 10.1097/00006982-200306000-00001. PMID: 12824826
Photodynamic therapy of subfoveal recurrences after laser photocoagulation of extrafoveal choroidal neovascularization in pathologic myopia.
Bandello F, Lanzetta P, Battaglia Parodi M, Roman-Pognuz D, Saviano S, Ravalico G
Graefes Arch Clin Exp Ophthalmol 2003 Jul;241(7):567-570. Epub 2003 Jun 18 doi: 10.1007/s00417-003-0686-9. PMID: 12819976
Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Macular Photocoagulation Study Group.
Arch Ophthalmol 1993 Sep;111(9):1189-99. doi: 10.1001/archopht.1993.01090090041018. PMID: 7689826

Diagnosis

Optical coherence tomography angiography-guided photodynamic therapy for extrafoveal choroidal neovascularization.
Chawla R, Hasan N, Sundar D, Sharma A
Digit J Ophthalmol 2020 Jan;26(1):1-7. Epub 2020 Mar 31 doi: 10.5693/djo.02.2020.01.001. PMID: 32547330Free PMC Article
Intravitreal bevacizumab for extrafoveal choroidal neovascularization secondary to pathologic myopia.
Parodi MB, Iacono P, Papayannis A, Kontadakis S, Cascavilla ML, Zucchiatti I, Bandello F
Retina 2013 Mar;33(3):593-7. doi: 10.1097/IAE.0b013e31826b6731. PMID: 23190919
Intravitreal bevacizumab for extrafoveal choroidal neovascularization after ocular trauma.
De Benedetto U, Battaglia Parodi M, Knutsson KA, Librando A, Bandello F, Lanzetta P, Iacono P
J Ocul Pharmacol Ther 2012 Oct;28(5):550-2. Epub 2012 May 3 doi: 10.1089/jop.2012.0022. PMID: 22554238
CME review: A cost-utility analysis of laser photocoagulation for extrafoveal choroidal neovascularization.
Busbee BG, Brown MM, Brown GC, Sharma S
Retina 2003 Jun;23(3):279-87; ; quiz 443-4. doi: 10.1097/00006982-200306000-00001. PMID: 12824826
Photodynamic therapy of subfoveal recurrences after laser photocoagulation of extrafoveal choroidal neovascularization in pathologic myopia.
Bandello F, Lanzetta P, Battaglia Parodi M, Roman-Pognuz D, Saviano S, Ravalico G
Graefes Arch Clin Exp Ophthalmol 2003 Jul;241(7):567-570. Epub 2003 Jun 18 doi: 10.1007/s00417-003-0686-9. PMID: 12819976

Therapy

Intravitreal ranibizumab for naive extrafoveal choroidal neovascularization secondary to age-related macular degeneration.
Parodi MB, Iacono P, La Spina C, Iuliano L, Lo Giudice G, Introini U, Bandello F
Retina 2014 Nov;34(11):2167-70. doi: 10.1097/IAE.0000000000000223. PMID: 24999724
Combined intravitreal anti-VEGF and verteporfin photodynamic therapy for juxtafoveal and extrafoveal choroidal neovascularization as an alternative to laser photocoagulation.
Han DP, McAllister JT, Weinberg DV, Kim JE, Wirostko WJ
Eye (Lond) 2010 Apr;24(4):713-6. Epub 2009 Jun 5 doi: 10.1038/eye.2009.122. PMID: 19498454
CME review: A cost-utility analysis of laser photocoagulation for extrafoveal choroidal neovascularization.
Busbee BG, Brown MM, Brown GC, Sharma S
Retina 2003 Jun;23(3):279-87; ; quiz 443-4. doi: 10.1097/00006982-200306000-00001. PMID: 12824826
Photodynamic therapy of subfoveal recurrences after laser photocoagulation of extrafoveal choroidal neovascularization in pathologic myopia.
Bandello F, Lanzetta P, Battaglia Parodi M, Roman-Pognuz D, Saviano S, Ravalico G
Graefes Arch Clin Exp Ophthalmol 2003 Jul;241(7):567-570. Epub 2003 Jun 18 doi: 10.1007/s00417-003-0686-9. PMID: 12819976
Treatment of juxtafoveal and extrafoveal choroidal neovascularization in the era of photodynamic therapy with verteporfin.
Jampol LM, Scott L
Am J Ophthalmol 2002 Jul;134(1):99-101. doi: 10.1016/s0002-9394(02)01463-0. PMID: 12095815

Prognosis

Intravitreal ranibizumab for naive extrafoveal choroidal neovascularization secondary to age-related macular degeneration.
Parodi MB, Iacono P, La Spina C, Iuliano L, Lo Giudice G, Introini U, Bandello F
Retina 2014 Nov;34(11):2167-70. doi: 10.1097/IAE.0000000000000223. PMID: 24999724
Combined intravitreal anti-VEGF and verteporfin photodynamic therapy for juxtafoveal and extrafoveal choroidal neovascularization as an alternative to laser photocoagulation.
Han DP, McAllister JT, Weinberg DV, Kim JE, Wirostko WJ
Eye (Lond) 2010 Apr;24(4):713-6. Epub 2009 Jun 5 doi: 10.1038/eye.2009.122. PMID: 19498454
Photocoagulation of well-defined choroidal neovascularization in age-related macular degeneration: clinicopathologic correlation.
Schneider S, Greven CM, Green WR
Retina 1998;18(3):242-50. doi: 10.1097/00006982-199803000-00009. PMID: 9654416
Long-term results of laser treatment in the ocular histoplasmosis syndrome.
Cummings HL, Rehmar AJ, Wood WJ, Isernhagen RD
Arch Ophthalmol 1995 Apr;113(4):465-8. doi: 10.1001/archopht.1995.01100040081031. PMID: 7535999
Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Macular Photocoagulation Study Group.
Arch Ophthalmol 1993 Sep;111(9):1189-99. doi: 10.1001/archopht.1993.01090090041018. PMID: 7689826

Clinical prediction guides

Unilateral extrafoveal choroidal . ......... eovascularization in a 13-year-old child with bilateral optic nerve drusen.
Jedrzejczak-Strózniak M, Siwiec-Prościńska J, Gotz-Wieckowska A, Kociecki J
Klin Oczna 2013;115(3):230-3. PMID: 24741930
Verteporfin therapy combined with intravitreal triamcinolone in all types of choroidal neovascularization due to age-related macular degeneration.
Augustin AJ, Schmidt-Erfurth U
Ophthalmology 2006 Jan;113(1):14-22. Epub 2005 Dec 19 doi: 10.1016/j.ophtha.2005.09.002. PMID: 16360209
CME review: A cost-utility analysis of laser photocoagulation for extrafoveal choroidal neovascularization.
Busbee BG, Brown MM, Brown GC, Sharma S
Retina 2003 Jun;23(3):279-87; ; quiz 443-4. doi: 10.1097/00006982-200306000-00001. PMID: 12824826
Long-term results of laser treatment in the ocular histoplasmosis syndrome.
Cummings HL, Rehmar AJ, Wood WJ, Isernhagen RD
Arch Ophthalmol 1995 Apr;113(4):465-8. doi: 10.1001/archopht.1995.01100040081031. PMID: 7535999

Recent systematic reviews

Relative cost of a line of vision in age-related macular degeneration.
Smiddy WE
Ophthalmology 2007 May;114(5):847-54. Epub 2007 Feb 16 doi: 10.1016/j.ophtha.2006.10.038. PMID: 17306878

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