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Superficial dermal perivascular inflammatory infiltrate

MedGen UID:
1620848
•Concept ID:
C4531290
•
Anatomical Abnormality
Synonym: Superficial perivascular inflammatory infiltrate
 
HPO: HP:0031190

Definition

Numerous lymphocytes surrounding blood vessels in the superfical part of the dermis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSuperficial dermal perivascular inflammatory infiltrate

Conditions with this feature

Erythrokeratodermia variabilis et progressiva 6
MedGen UID:
1681026
•Concept ID:
C5193144
•
Disease or Syndrome
EKVP6 is characterized by erythematous hyperkeratotic plaques that develop within the first year of life, beginning on distal extremities and progressing to involve the face, wrists, and ankles, with sparing of volar surfaces. Intrafamilial variation in severity has been observed, and most affected individuals experience slowly progressive spontaneous remission after puberty (Wang et al., 2019). For a general phenotypic description and discussion of genetic heterogeneity of EKVP, see EKVP1 (133200).
See: Condition Record
Erythrokeratodermia variabilis et progressiva 6

Professional guidelines

PubMed

Tumid lupus erythematosus: criteria for classification with immunohistochemical analysis.
Alexiades-Armenakas MR, Baldassano M, Bince B, Werth V, Bystryn JC, Kamino H, Soter NA, Franks AG Jr
Arthritis Rheum 2003 Aug 15;49(4):494-500. doi: 10.1002/art.11206. PMID: 12910555
Histologic criteria for the diagnosis of pityriasis rubra pilaris.
Soeprono FF
Am J Dermatopathol 1986 Aug;8(4):277-83. doi: 10.1097/00000372-198608000-00001. PMID: 3766917

Recent clinical studies

Etiology

Monkeypox outbreak in Genoa, Italy: Clinical, laboratory, histopathologic features, management, and outcome of the infected patients.
Ciccarese G, Di Biagio A, Bruzzone B, Guadagno A, Taramasso L, Oddenino G, Brucci G, Labate L, De Pace V, Mastrolonardo M, Broccolo F, Robello G, Drago F, Bassetti M, Parodi A
J Med Virol 2023 Feb;95(2):e28560. doi: 10.1002/jmv.28560. PMID: 36757085
Idiopathic perniosis presenting as acral purpuric lesions: Clustering of cases before COVID-19 pandemic and their comparison with chilblain like lesions reported in the literature.
Jindal R, Chauhan P, Goyal D, Shirazi N
Dermatol Ther 2021 May;34(3):e14951. Epub 2021 Mar 27 doi: 10.1111/dth.14951. PMID: 33740317Free PMC Article
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Imported fire ant envenomation: A clinicopathologic study of a recognizable form of arthropod assault reaction.
Villada G, Hafeez F, Ollague J, Nousari CH, Elgart GW
J Cutan Pathol 2017 Dec;44(12):1012-1017. Epub 2017 Sep 21 doi: 10.1111/cup.13036. PMID: 28873251
Cutaneous drug eruptions: a 5-year experience.
Gerson D, Sriganeshan V, Alexis JB
J Am Acad Dermatol 2008 Dec;59(6):995-9. doi: 10.1016/j.jaad.2008.09.015. PMID: 19022101

Diagnosis

Capillaritis as a Skin Manifestation of Hepatosplenic Gamma-Delta T-Cell Lymphoma.
Jakharia-Shah N, Ho B, Lolatgis H, Alarcon L, Abdul-Wahab A
J Pediatr Hematol Oncol 2022 Apr 1;44(3):e733-e735. doi: 10.1097/MPH.0000000000002336. PMID: 35319511
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Pityriasis Lichenoides: A Large Histopathological Case Series With a Focus on Adnexotropism.
Menzinger S, Frassati-Biaggi A, Leclerc-Mercier S, Bodemer C, Molina TJ, Fraitag S
Am J Dermatopathol 2020 Jan;42(1):1-10. doi: 10.1097/DAD.0000000000001448. PMID: 31880634
Morphoea with prominent plasma cell endoneuritis.
Singh M, Farquharson N, Owen C, Howat AJ, Singh S, Francis N, Calonje E
Clin Exp Dermatol 2017 Mar;42(2):196-199. Epub 2017 Jan 4 doi: 10.1111/ced.13029. PMID: 28052367
Erythema dyschromicum perstans.
Tlougan BE, Gonzalez ME, Mandal RV, Kundu RV, Skopicki D
Dermatol Online J 2010 Nov 15;16(11):17. PMID: 21163168

Therapy

Case Report: Morbihan disease treated with tofacitinib successfully.
Li ZY, Chi CC, Cai SQ
Front Immunol 2023;14:1177316. Epub 2023 Jun 5 doi: 10.3389/fimmu.2023.1177316. PMID: 37342330Free PMC Article
Imported fire ant envenomation: A clinicopathologic study of a recognizable form of arthropod assault reaction.
Villada G, Hafeez F, Ollague J, Nousari CH, Elgart GW
J Cutan Pathol 2017 Dec;44(12):1012-1017. Epub 2017 Sep 21 doi: 10.1111/cup.13036. PMID: 28873251
Sweet-like reaction due to arthropod bites: a histopathologic pitfall.
Battistella M, Bourrat E, Fardet L, Saada V, Janin A, Vignon-Pennamen MD
Am J Dermatopathol 2012 Jun;34(4):442-5. doi: 10.1097/DAD.0b013e3182313509. PMID: 22172958
Gianotti-Crosti syndrome presenting as lichenoid dermatitis.
Stefanato CM, Goldberg LJ, Andersen WK, Bhawan J
Am J Dermatopathol 2000 Apr;22(2):162-5. doi: 10.1097/00000372-200004000-00013. PMID: 10770438
Pseudoporphyria associated with Relafen therapy.
Magro CM, Crowson AN
J Cutan Pathol 1999 Jan;26(1):42-7. doi: 10.1111/j.1600-0560.1999.tb01789.x. PMID: 10189244

Prognosis

Monkeypox outbreak in Genoa, Italy: Clinical, laboratory, histopathologic features, management, and outcome of the infected patients.
Ciccarese G, Di Biagio A, Bruzzone B, Guadagno A, Taramasso L, Oddenino G, Brucci G, Labate L, De Pace V, Mastrolonardo M, Broccolo F, Robello G, Drago F, Bassetti M, Parodi A
J Med Virol 2023 Feb;95(2):e28560. doi: 10.1002/jmv.28560. PMID: 36757085
Capillaritis as a Skin Manifestation of Hepatosplenic Gamma-Delta T-Cell Lymphoma.
Jakharia-Shah N, Ho B, Lolatgis H, Alarcon L, Abdul-Wahab A
J Pediatr Hematol Oncol 2022 Apr 1;44(3):e733-e735. doi: 10.1097/MPH.0000000000002336. PMID: 35319511
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Cutaneous infiltrates of acute myelogenous leukemia simulating inflammatory dermatoses.
Martínez-Escanamé M, Zuriel D, Tee SI, Fried I, Massone C, Cerroni L
Am J Dermatopathol 2013 Jun;35(4):419-24. doi: 10.1097/DAD.0b013e31826ffe6f. PMID: 23221486
Tumid lupus erythematosus: criteria for classification with immunohistochemical analysis.
Alexiades-Armenakas MR, Baldassano M, Bince B, Werth V, Bystryn JC, Kamino H, Soter NA, Franks AG Jr
Arthritis Rheum 2003 Aug 15;49(4):494-500. doi: 10.1002/art.11206. PMID: 12910555

Clinical prediction guides

Case Report: Morbihan disease treated with tofacitinib successfully.
Li ZY, Chi CC, Cai SQ
Front Immunol 2023;14:1177316. Epub 2023 Jun 5 doi: 10.3389/fimmu.2023.1177316. PMID: 37342330Free PMC Article
Monkeypox outbreak in Genoa, Italy: Clinical, laboratory, histopathologic features, management, and outcome of the infected patients.
Ciccarese G, Di Biagio A, Bruzzone B, Guadagno A, Taramasso L, Oddenino G, Brucci G, Labate L, De Pace V, Mastrolonardo M, Broccolo F, Robello G, Drago F, Bassetti M, Parodi A
J Med Virol 2023 Feb;95(2):e28560. doi: 10.1002/jmv.28560. PMID: 36757085
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Pityriasis Lichenoides: A Large Histopathological Case Series With a Focus on Adnexotropism.
Menzinger S, Frassati-Biaggi A, Leclerc-Mercier S, Bodemer C, Molina TJ, Fraitag S
Am J Dermatopathol 2020 Jan;42(1):1-10. doi: 10.1097/DAD.0000000000001448. PMID: 31880634
Evolution, maturation, and regression of lesions of psoriasis. New observations and correlation of clinical and histologic findings.
Ragaz A, Ackerman AB
Am J Dermatopathol 1979 Fall;1(3):199-214. doi: 10.1097/00000372-197900130-00002. PMID: 543520

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