U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Double-Expressor Lymphoma

MedGen UID:
1621606
•Concept ID:
C4524186
•
Neoplastic Process
Synonyms: Double Expressor Lymphoma; Double-Expressing Lymphoma

Definition

A diffuse large B-cell lymphoma characterized by double expression of MYC and BCL2 proteins without MYC and BCL2 gene aberrations. These lymphomas may have a worse prognosis than other diffuse large B-cell lymphomas, not otherwise specified, but they are not as aggressive as the high-grade B-cell lymphomas, with rearrangements of MYC and BCL2 and/or BCL6 genes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDouble-Expressor Lymphoma

Professional guidelines

PubMed

Clinical significance of plasma PD-L1(+) exosomes in the management of diffuse large B cell lymphoma.
Xu P, Liu J, Chen H, Shang L, Wang F, Zhu Y, Guo Y, Li F, Yan F, Xie X, Li L, Gu W, Lin Y
Ann Hematol 2023 Sep;102(9):2435-2444. Epub 2023 May 10 doi: 10.1007/s00277-023-05259-6. PMID: 37162517
Dose-adjusted EPOCH and rituximab for the treatment of double expressor and double-hit diffuse large B-cell lymphoma: impact of TP53 mutations on clinical outcome.
Dodero A, Guidetti A, Marino F, Tucci A, Barretta F, Re A, Balzarotti M, Carniti C, Monfrini C, Chiappella A, Cabras A, Facchetti F, Pennisi M, Rahal D, Monti V, Devizzi L, Miceli R, Cocito F, Farina L, Ricci F, Rossi G, Carlo-Stella C, Corradini P
Haematologica 2022 May 1;107(5):1153-1162. doi: 10.3324/haematol.2021.278638. PMID: 34289655Free PMC Article
Double hit and double expressors in lymphoma: Definition and treatment.
Riedell PA, Smith SM
Cancer 2018 Dec 15;124(24):4622-4632. Epub 2018 Sep 25 doi: 10.1002/cncr.31646. PMID: 30252929

Recent clinical studies

Etiology

Genetic Profiling of Diffuse Large B-Cell Lymphoma: A Comparison Between Double-Expressor Lymphoma and Non-Double-Expressor Lymphoma.
Chen H, Qin Y, Liu P, Yang J, Gui L, He X, Zhang C, Zhou S, Zhou L, Yang S, Shi Y
Mol Diagn Ther 2023 Jan;27(1):75-86. Epub 2022 Nov 18 doi: 10.1007/s40291-022-00621-2. PMID: 36401148
R-CHOP Vs DA-EPOCH-R for Double-Expressor Lymphoma: A University of California Hematologic Malignancies Consortium Retrospective Analysis.
Othman T, Penaloza J, Zhang S, Daniel CE, Gaut D, Oliai C, Brem EA, Baweja A, Ly J, Reid J, Pinter-Brown L, Lee M, Abdulhaq H, Tuscano J
Clin Lymphoma Myeloma Leuk 2022 Oct;22(10):e947-e957. Epub 2022 Jun 30 doi: 10.1016/j.clml.2022.06.013. PMID: 35858904
Fitting double-hit lymphoma into the aggressive lymphoma spectrum: a square peg in a round hole?
Gordon MJ, Westin JR
Leuk Lymphoma 2022 May;63(5):1034-1044. Epub 2021 Nov 28 doi: 10.1080/10428194.2021.2008383. PMID: 34842019
Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.
Herrera AF, Rodig SJ, Song JY, Kim Y, Griffin GK, Yang D, Nikolaenko L, Mei M, Bedell V, Dal Cin P, Pak C, Alyea EP, Budde LE, Chen R, Chen YB, Chan WC, Cutler CS, Ho VT, Koreth J, Krishnan A, Murata-Collins JL, Nikiforow S, Palmer J, Pihan GA, Pillai R, Popplewell L, Rosen ST, Siddiqi T, Sohani AR, Zain J, Kwak LW, Weisenburger DD, Weinstock DM, Soiffer RJ, Antin JH, Forman SJ, Nademanee AP, Armand P
Biol Blood Marrow Transplant 2018 Mar;24(3):514-520. Epub 2017 Nov 28 doi: 10.1016/j.bbmt.2017.11.023. PMID: 29196080Free PMC Article
Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation.
Kawashima I, Inamoto Y, Maeshima AM, Nomoto J, Tajima K, Honda T, Shichijo T, Kawajiri A, Takemura T, Onishi A, Ito A, Tanaka T, Fuji S, Kurosawa S, Kim SW, Maruyama D, Tobinai K, Kobayashi Y, Fukuda T
Biol Blood Marrow Transplant 2018 Feb;24(2):294-300. Epub 2017 Oct 14 doi: 10.1016/j.bbmt.2017.10.013. PMID: 29037890

Diagnosis

R-CHOP Vs DA-EPOCH-R for Double-Expressor Lymphoma: A University of California Hematologic Malignancies Consortium Retrospective Analysis.
Othman T, Penaloza J, Zhang S, Daniel CE, Gaut D, Oliai C, Brem EA, Baweja A, Ly J, Reid J, Pinter-Brown L, Lee M, Abdulhaq H, Tuscano J
Clin Lymphoma Myeloma Leuk 2022 Oct;22(10):e947-e957. Epub 2022 Jun 30 doi: 10.1016/j.clml.2022.06.013. PMID: 35858904
Fitting double-hit lymphoma into the aggressive lymphoma spectrum: a square peg in a round hole?
Gordon MJ, Westin JR
Leuk Lymphoma 2022 May;63(5):1034-1044. Epub 2021 Nov 28 doi: 10.1080/10428194.2021.2008383. PMID: 34842019
Frequency Of Double Expressor Lymphoma In A Tertiary Care Hospital.
Hassan M, Khattak MT, Qamar MA, Javed S, Saeed SU
J Ayub Med Coll Abbottabad 2021 Jan-Mar;33(1):44-48. PMID: 33774953
Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation.
Kawashima I, Inamoto Y, Maeshima AM, Nomoto J, Tajima K, Honda T, Shichijo T, Kawajiri A, Takemura T, Onishi A, Ito A, Tanaka T, Fuji S, Kurosawa S, Kim SW, Maruyama D, Tobinai K, Kobayashi Y, Fukuda T
Biol Blood Marrow Transplant 2018 Feb;24(2):294-300. Epub 2017 Oct 14 doi: 10.1016/j.bbmt.2017.10.013. PMID: 29037890
Current treatment of double hit and double expressor lymphoma.
Reagan PM, Davies A
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):295-297. doi: 10.1182/asheducation-2017.1.295. PMID: 29222269Free PMC Article

Therapy

R-CHOP Vs DA-EPOCH-R for Double-Expressor Lymphoma: A University of California Hematologic Malignancies Consortium Retrospective Analysis.
Othman T, Penaloza J, Zhang S, Daniel CE, Gaut D, Oliai C, Brem EA, Baweja A, Ly J, Reid J, Pinter-Brown L, Lee M, Abdulhaq H, Tuscano J
Clin Lymphoma Myeloma Leuk 2022 Oct;22(10):e947-e957. Epub 2022 Jun 30 doi: 10.1016/j.clml.2022.06.013. PMID: 35858904
Fitting double-hit lymphoma into the aggressive lymphoma spectrum: a square peg in a round hole?
Gordon MJ, Westin JR
Leuk Lymphoma 2022 May;63(5):1034-1044. Epub 2021 Nov 28 doi: 10.1080/10428194.2021.2008383. PMID: 34842019
Dose-adjusted EPOCH and rituximab for the treatment of double expressor and double-hit diffuse large B-cell lymphoma: impact of TP53 mutations on clinical outcome.
Dodero A, Guidetti A, Marino F, Tucci A, Barretta F, Re A, Balzarotti M, Carniti C, Monfrini C, Chiappella A, Cabras A, Facchetti F, Pennisi M, Rahal D, Monti V, Devizzi L, Miceli R, Cocito F, Farina L, Ricci F, Rossi G, Carlo-Stella C, Corradini P
Haematologica 2022 May 1;107(5):1153-1162. doi: 10.3324/haematol.2021.278638. PMID: 34289655Free PMC Article
Double hit and double expressors in lymphoma: Definition and treatment.
Riedell PA, Smith SM
Cancer 2018 Dec 15;124(24):4622-4632. Epub 2018 Sep 25 doi: 10.1002/cncr.31646. PMID: 30252929
Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.
Herrera AF, Rodig SJ, Song JY, Kim Y, Griffin GK, Yang D, Nikolaenko L, Mei M, Bedell V, Dal Cin P, Pak C, Alyea EP, Budde LE, Chen R, Chen YB, Chan WC, Cutler CS, Ho VT, Koreth J, Krishnan A, Murata-Collins JL, Nikiforow S, Palmer J, Pihan GA, Pillai R, Popplewell L, Rosen ST, Siddiqi T, Sohani AR, Zain J, Kwak LW, Weisenburger DD, Weinstock DM, Soiffer RJ, Antin JH, Forman SJ, Nademanee AP, Armand P
Biol Blood Marrow Transplant 2018 Mar;24(3):514-520. Epub 2017 Nov 28 doi: 10.1016/j.bbmt.2017.11.023. PMID: 29196080Free PMC Article

Prognosis

Clinicopathologic and genetic features of the starry-sky pattern in double-expressor diffuse large B-cell lymphoma.
Sung HJ, Kim D, Yoon DH, Cho H, Huh J, Suh CW, Go H
Hum Pathol 2023 Sep;139:106-116. Epub 2023 Jul 29 doi: 10.1016/j.humpath.2023.07.008. PMID: 37517597
Fitting double-hit lymphoma into the aggressive lymphoma spectrum: a square peg in a round hole?
Gordon MJ, Westin JR
Leuk Lymphoma 2022 May;63(5):1034-1044. Epub 2021 Nov 28 doi: 10.1080/10428194.2021.2008383. PMID: 34842019
Double hit and double expressors in lymphoma: Definition and treatment.
Riedell PA, Smith SM
Cancer 2018 Dec 15;124(24):4622-4632. Epub 2018 Sep 25 doi: 10.1002/cncr.31646. PMID: 30252929
Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.
Herrera AF, Rodig SJ, Song JY, Kim Y, Griffin GK, Yang D, Nikolaenko L, Mei M, Bedell V, Dal Cin P, Pak C, Alyea EP, Budde LE, Chen R, Chen YB, Chan WC, Cutler CS, Ho VT, Koreth J, Krishnan A, Murata-Collins JL, Nikiforow S, Palmer J, Pihan GA, Pillai R, Popplewell L, Rosen ST, Siddiqi T, Sohani AR, Zain J, Kwak LW, Weisenburger DD, Weinstock DM, Soiffer RJ, Antin JH, Forman SJ, Nademanee AP, Armand P
Biol Blood Marrow Transplant 2018 Mar;24(3):514-520. Epub 2017 Nov 28 doi: 10.1016/j.bbmt.2017.11.023. PMID: 29196080Free PMC Article
Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation.
Kawashima I, Inamoto Y, Maeshima AM, Nomoto J, Tajima K, Honda T, Shichijo T, Kawajiri A, Takemura T, Onishi A, Ito A, Tanaka T, Fuji S, Kurosawa S, Kim SW, Maruyama D, Tobinai K, Kobayashi Y, Fukuda T
Biol Blood Marrow Transplant 2018 Feb;24(2):294-300. Epub 2017 Oct 14 doi: 10.1016/j.bbmt.2017.10.013. PMID: 29037890

Clinical prediction guides

Genetic Profiling of Diffuse Large B-Cell Lymphoma: A Comparison Between Double-Expressor Lymphoma and Non-Double-Expressor Lymphoma.
Chen H, Qin Y, Liu P, Yang J, Gui L, He X, Zhang C, Zhou S, Zhou L, Yang S, Shi Y
Mol Diagn Ther 2023 Jan;27(1):75-86. Epub 2022 Nov 18 doi: 10.1007/s40291-022-00621-2. PMID: 36401148
Dose-adjusted EPOCH and rituximab for the treatment of double expressor and double-hit diffuse large B-cell lymphoma: impact of TP53 mutations on clinical outcome.
Dodero A, Guidetti A, Marino F, Tucci A, Barretta F, Re A, Balzarotti M, Carniti C, Monfrini C, Chiappella A, Cabras A, Facchetti F, Pennisi M, Rahal D, Monti V, Devizzi L, Miceli R, Cocito F, Farina L, Ricci F, Rossi G, Carlo-Stella C, Corradini P
Haematologica 2022 May 1;107(5):1153-1162. doi: 10.3324/haematol.2021.278638. PMID: 34289655Free PMC Article
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Upfront autologous hematopoietic stem cell transplantation for high-risk patients with double-expressor diffuse large B cell lymphoma.
Kim YR, Yoon SO, Kim SJ, Cheong JW, Chung H, Lee JY, Jang JE, Kim Y, Yang WI, Min YH, Kim JS
Ann Hematol 2020 Sep;99(9):2149-2157. Epub 2020 May 10 doi: 10.1007/s00277-020-04043-0. PMID: 32390113
Multimodality imaging for early diagnosis and treatment of primary cardiac diffuse 'double-expressor' lymphoma.
Roncon L, Marco Z, Aggio S, Rigatelli G, Rinuncini M
J Cardiovasc Med (Hagerstown) 2019 Dec;20(12):851-852. doi: 10.2459/JCM.0000000000000847. PMID: 31356516

Recent systematic reviews

DA-EPOCH-R improves the prognosis of patients with double-expressor lymphoma: A single-center retrospective study and meta-analysis.
Zhan J, Yang S, Zhang W, Zhou D, Zhang Y, Wang W, Wei C
Medicine (Baltimore) 2022 Sep 23;101(38):e30620. doi: 10.1097/MD.0000000000030620. PMID: 36197215Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...