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Lung Non-Mucinous Adenocarcinoma In Situ

MedGen UID:
1621951
•Concept ID:
C4526914
•
Neoplastic Process
Synonym: Non-mucinous adenocarcinoma in situ of lung
SNOMED CT: Non-mucinous adenocarcinoma in situ of lung (789695003)

Definition

Lung adenocarcinoma in situ characterized by the presence of type II pneumocyte and/or Clara cell differentiation. Almost all cases of lung adenocarcinoma in situ are non-mucinous. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Non-Mucinous Adenocarcinoma In Situ

Professional guidelines

PubMed

The effect that pathologic and radiologic interpretation of invasive and non-invasive areas in lung adenocarcinoma has on T-stage and treatment.
Hart JL, Canepa M, Agarwal S, Lu S, Azzoli C, Garcia-Moliner M
Ann Diagn Pathol 2021 Oct;54:151799. Epub 2021 Jul 20 doi: 10.1016/j.anndiagpath.2021.151799. PMID: 34311302

Recent clinical studies

Etiology

The effect that pathologic and radiologic interpretation of invasive and non-invasive areas in lung adenocarcinoma has on T-stage and treatment.
Hart JL, Canepa M, Agarwal S, Lu S, Azzoli C, Garcia-Moliner M
Ann Diagn Pathol 2021 Oct;54:151799. Epub 2021 Jul 20 doi: 10.1016/j.anndiagpath.2021.151799. PMID: 34311302
Distinctive clinicopathological features of adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung: A retrospective study.
Ishida H, Shimizu Y, Sakaguchi H, Nitanda H, Kaneko K, Yamazaki N, Yanagihara A, Taguchi R, Sakai F, Yasuda M, Kobayashi K
Lung Cancer 2019 Mar;129:16-21. Epub 2018 Dec 19 doi: 10.1016/j.lungcan.2018.12.020. PMID: 30797486
The percentage of lepidic growth is an independent prognostic factor in invasive adenocarcinoma of the lung.
Strand TE, Rostad H, Strøm EH, Hasleton P
Diagn Pathol 2015 Jul 9;10:94. doi: 10.1186/s13000-015-0335-8. PMID: 26159539Free PMC Article
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
Zhang Z, Wang A, Sun B, Zhan Z, Chen K, Wang C
J Cardiothorac Surg 2013 Apr 16;8:95. doi: 10.1186/1749-8090-8-95. PMID: 23591077Free PMC Article
Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases.
Yoshizawa A, Motoi N, Riely GJ, Sima CS, Gerald WL, Kris MG, Park BJ, Rusch VW, Travis WD
Mod Pathol 2011 May;24(5):653-64. Epub 2011 Jan 21 doi: 10.1038/modpathol.2010.232. PMID: 21252858

Diagnosis

Invasion and Grading of Pulmonary Non-Mucinous Adenocarcinoma.
Moreira AL, Zhou F
Surg Pathol Clin 2024 Jun;17(2):271-285. Epub 2023 Dec 21 doi: 10.1016/j.path.2023.11.009. PMID: 38692810
The effect that pathologic and radiologic interpretation of invasive and non-invasive areas in lung adenocarcinoma has on T-stage and treatment.
Hart JL, Canepa M, Agarwal S, Lu S, Azzoli C, Garcia-Moliner M
Ann Diagn Pathol 2021 Oct;54:151799. Epub 2021 Jul 20 doi: 10.1016/j.anndiagpath.2021.151799. PMID: 34311302
Mucinous adenocarcinoma arising in congenital pulmonary airway malformation: clinicopathological analysis of 37 cases.
Chang WC, Zhang YZ, Wolf JL, Hermelijn SM, Schnater JM, von der Thüsen JH, Rice A, Lantuejoul S, Mastroianni B, Farver C, Black F, Popat S, Nicholson AG
Histopathology 2021 Feb;78(3):434-444. Epub 2020 Oct 23 doi: 10.1111/his.14239. PMID: 32810914
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
The value of CT attenuation in distinguishing atypical adenomatous hyperplasia from adenocarcinoma in situ.
Jiang B, Wang J, Jia P, Le M
Zhongguo Fei Ai Za Zhi 2013 Nov;16(11):579-83. doi: 10.3779/j.issn.1009-3419.2013.11.03. PMID: 24229623Free PMC Article

Prognosis

Invasion and Grading of Pulmonary Non-Mucinous Adenocarcinoma.
Moreira AL, Zhou F
Surg Pathol Clin 2024 Jun;17(2):271-285. Epub 2023 Dec 21 doi: 10.1016/j.path.2023.11.009. PMID: 38692810
The effect that pathologic and radiologic interpretation of invasive and non-invasive areas in lung adenocarcinoma has on T-stage and treatment.
Hart JL, Canepa M, Agarwal S, Lu S, Azzoli C, Garcia-Moliner M
Ann Diagn Pathol 2021 Oct;54:151799. Epub 2021 Jul 20 doi: 10.1016/j.anndiagpath.2021.151799. PMID: 34311302
Mucinous adenocarcinoma arising in congenital pulmonary airway malformation: clinicopathological analysis of 37 cases.
Chang WC, Zhang YZ, Wolf JL, Hermelijn SM, Schnater JM, von der Thüsen JH, Rice A, Lantuejoul S, Mastroianni B, Farver C, Black F, Popat S, Nicholson AG
Histopathology 2021 Feb;78(3):434-444. Epub 2020 Oct 23 doi: 10.1111/his.14239. PMID: 32810914
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
Zhang Z, Wang A, Sun B, Zhan Z, Chen K, Wang C
J Cardiothorac Surg 2013 Apr 16;8:95. doi: 10.1186/1749-8090-8-95. PMID: 23591077Free PMC Article

Clinical prediction guides

The effect that pathologic and radiologic interpretation of invasive and non-invasive areas in lung adenocarcinoma has on T-stage and treatment.
Hart JL, Canepa M, Agarwal S, Lu S, Azzoli C, Garcia-Moliner M
Ann Diagn Pathol 2021 Oct;54:151799. Epub 2021 Jul 20 doi: 10.1016/j.anndiagpath.2021.151799. PMID: 34311302
Mucinous adenocarcinoma arising in congenital pulmonary airway malformation: clinicopathological analysis of 37 cases.
Chang WC, Zhang YZ, Wolf JL, Hermelijn SM, Schnater JM, von der Thüsen JH, Rice A, Lantuejoul S, Mastroianni B, Farver C, Black F, Popat S, Nicholson AG
Histopathology 2021 Feb;78(3):434-444. Epub 2020 Oct 23 doi: 10.1111/his.14239. PMID: 32810914
The percentage of lepidic growth is an independent prognostic factor in invasive adenocarcinoma of the lung.
Strand TE, Rostad H, Strøm EH, Hasleton P
Diagn Pathol 2015 Jul 9;10:94. doi: 10.1186/s13000-015-0335-8. PMID: 26159539Free PMC Article
The value of CT attenuation in distinguishing atypical adenomatous hyperplasia from adenocarcinoma in situ.
Jiang B, Wang J, Jia P, Le M
Zhongguo Fei Ai Za Zhi 2013 Nov;16(11):579-83. doi: 10.3779/j.issn.1009-3419.2013.11.03. PMID: 24229623Free PMC Article
Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas.
Sakamoto H, Shimizu J, Horio Y, Ueda R, Takahashi T, Mitsudomi T, Yatabe Y
J Pathol 2007 Jul;212(3):287-94. doi: 10.1002/path.2165. PMID: 17534846

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