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Small cerebellar cortex

MedGen UID:
1622266
•Concept ID:
C4531131
•
Finding
HPO: HP:0031423

Definition

Reduced size of the cerebellar cortex. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall cerebellar cortex

Professional guidelines

PubMed

Functional connectivity between the cerebellar vermis and cerebrum distinguishes early treatment response for major depressive episodes in adolescents.
Wang L, Zhao P, Zhang J, Zhang R, Liu J, Duan J, Zhang X, Zhu R, Wang F
J Affect Disord 2023 Oct 15;339:256-263. Epub 2023 Jul 10 doi: 10.1016/j.jad.2023.07.054. PMID: 37437740
Prenatal diagnosis of rhombencephalosynapsis: neuroimaging features and severity of vermian anomaly.
Krajden Haratz K, Oliveira Szejnfeld P, Govindaswamy M, Leibovitz Z, Gindes L, Severino M, Rossi A, Paladini D, Garcia Rodriguez R, Ben-Sira L, Borkowski Tillman T, Gupta R, Lotem G, Raz N, Hamamoto TENK, Kidron D, Arad A, Birnbaum R, Brussilov M, Pomar L, Vial Y, Leventer RJ, McGillivray G, Fink M, Krzeszowski W, Fernandes Moron A, Lev D, Tamarkin M, Shalev J, Har Toov J, Lerman-Sagie T, Malinger G
Ultrasound Obstet Gynecol 2021 Dec;58(6):864-874. doi: 10.1002/uog.23660. PMID: 33942916
Transcranial magnetic stimulation in hereditary ataxias: Diagnostic utility, pathophysiological insight and treatment.
Rodríguez-Labrada R, Velázquez-Pérez L, Ziemann U
Clin Neurophysiol 2018 Aug;129(8):1688-1698. Epub 2018 Jun 15 doi: 10.1016/j.clinph.2018.06.003. PMID: 29940480

Recent clinical studies

Etiology

Etiology of Primary Cerebellar Intracerebral Hemorrhage Based on Topographic Localization.
Incontri D, Marchina S, Andreev A, Wilson M, Wang JY, Lin D, Heistand EC, Carvalho F, Selim M, Lioutas VA
Stroke 2023 Dec;54(12):3074-3080. Epub 2023 Oct 16 doi: 10.1161/STROKEAHA.123.044271. PMID: 37842779Free PMC Article
Resting-state networks in schizophrenia.
Karbasforoushan H, Woodward ND
Curr Top Med Chem 2012;12(21):2404-14. doi: 10.2174/156802612805289863. PMID: 23279179
Tremor.
Raethjen J, Deuschl G
Curr Opin Neurol 2009 Aug;22(4):400-5. doi: 10.1097/WCO.0b013e32832dc056. PMID: 19553813
Neuropathological findings in autism.
Palmen SJ, van Engeland H, Hof PR, Schmitz C
Brain 2004 Dec;127(Pt 12):2572-83. Epub 2004 Aug 25 doi: 10.1093/brain/awh287. PMID: 15329353
Principles of synaptic transmission.
Moore RY
Ann N Y Acad Sci 1993 Sep 24;695:1-9. doi: 10.1111/j.1749-6632.1993.tb23018.x. PMID: 7902053

Diagnosis

Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Neuroimaging in mitochondrial disorders.
Mascalchi M, Montomoli M, Guerrini R
Essays Biochem 2018 Jul 20;62(3):409-421. doi: 10.1042/EBC20170109. PMID: 30030366
MRI of Cerebellar Infarction.
De Cocker LJ, Lövblad KO, Hendrikse J
Eur Neurol 2017;77(3-4):137-146. Epub 2017 Jan 18 doi: 10.1159/000455229. PMID: 28095387
Tremor.
Raethjen J, Deuschl G
Curr Opin Neurol 2009 Aug;22(4):400-5. doi: 10.1097/WCO.0b013e32832dc056. PMID: 19553813
Gluten ataxia.
Hadjivassiliou M, Sanders DS, Woodroofe N, Williamson C, Grünewald RA
Cerebellum 2008;7(3):494-8. doi: 10.1007/s12311-008-0052-x. PMID: 18787912

Therapy

Serotonin 1A receptor density measured by F18-Mefway PET/CT in mesiotemporal cortex and raphe does not discriminate therapeutic response in patients with major depressive episode.
Barth M, Dunzinger A, Wimmer I, Winkler J, Rittmannsberger H, Nader M, Pichler R
Q J Nucl Med Mol Imaging 2020 Jun;64(2):203-210. Epub 2018 Jun 14 doi: 10.23736/S1824-4785.18.03039-X. PMID: 29916219
Cerebellar Microbleed Distribution Patterns and Cerebral Amyloid Angiopathy.
Pasi M, Pongpitakmetha T, Charidimou A, Singh SD, Tsai HH, Xiong L, Boulouis G, Warren AD, Rosand J, Frosch MP, Viswanathan A, Gurol ME, Greenberg SM
Stroke 2019 Jul;50(7):1727-1733. Epub 2019 Jun 4 doi: 10.1161/STROKEAHA.119.024843. PMID: 31159702Free PMC Article
Deep brain and cortical stimulation for epilepsy.
Sprengers M, Vonck K, Carrette E, Marson AG, Boon P
Cochrane Database Syst Rev 2017 Jul 18;7(7):CD008497. doi: 10.1002/14651858.CD008497.pub3. PMID: 28718878Free PMC Article
Update on the pharmacotherapy of cerebellar and central vestibular disorders.
Kalla R, Teufel J, Feil K, Muth C, Strupp M
J Neurol 2016 Apr;263 Suppl 1:S24-9. Epub 2016 Apr 15 doi: 10.1007/s00415-015-7987-x. PMID: 27083881Free PMC Article
Transcranial magnetic stimulation of the cerebellum.
Minks E, Kopickova M, Marecek R, Streitova H, Bares M
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2010 Jun;154(2):133-9. doi: 10.5507/bp.2010.020. PMID: 20668494

Prognosis

Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I.
Harmata GIS, Barsotti EJ, Casten LG, Fiedorowicz JG, Williams A, Shaffer JJ, Richards JG, Sathyaputri L, Schmitz SL, Christensen GE, Long JD, Gaine ME, Xu J, Michaelson JJ, Wemmie JA, Magnotta VA
J Affect Disord 2023 Nov 1;340:269-279. Epub 2023 Aug 8 doi: 10.1016/j.jad.2023.08.018. PMID: 37562560Free PMC Article
Population coding in the cerebellum: a machine learning perspective.
Shadmehr R
J Neurophysiol 2020 Dec 1;124(6):2022-2051. Epub 2020 Oct 28 doi: 10.1152/jn.00449.2020. PMID: 33112717Free PMC Article
Posterior fossa tumors in children: developmental anatomy and diagnostic imaging.
Raybaud C, Ramaswamy V, Taylor MD, Laughlin S
Childs Nerv Syst 2015 Oct;31(10):1661-76. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2834-z. PMID: 26351220
The mysterious microcircuitry of the cerebellar nuclei.
Uusisaari M, De Schutter E
J Physiol 2011 Jul 15;589(Pt 14):3441-57. Epub 2011 Apr 26 doi: 10.1113/jphysiol.2010.201582. PMID: 21521761Free PMC Article
The modifiable neuronal network of the cerebellum.
Ito M
Jpn J Physiol 1984;34(5):781-92. doi: 10.2170/jjphysiol.34.781. PMID: 6099855

Clinical prediction guides

Functional connectome of human cerebellum.
Chen Z, Zhang R, Huo H, Liu P, Zhang C, Feng T
Neuroimage 2022 May 1;251:119015. Epub 2022 Feb 19 doi: 10.1016/j.neuroimage.2022.119015. PMID: 35189360
Neuroimaging Biomarkers in SCA2 Gene Carriers.
Mascalchi M, Vella A
Int J Mol Sci 2020 Feb 4;21(3) doi: 10.3390/ijms21031020. PMID: 32033120Free PMC Article
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Resting-state networks in schizophrenia.
Karbasforoushan H, Woodward ND
Curr Top Med Chem 2012;12(21):2404-14. doi: 10.2174/156802612805289863. PMID: 23279179
The mysterious microcircuitry of the cerebellar nuclei.
Uusisaari M, De Schutter E
J Physiol 2011 Jul 15;589(Pt 14):3441-57. Epub 2011 Apr 26 doi: 10.1113/jphysiol.2010.201582. PMID: 21521761Free PMC Article

Recent systematic reviews

A Systematic Review on Anti-Yo/PCA-1 Antibody: Beyond Cerebellar Ataxia in Middle-Aged Women with Gynecologic Cancer.
Mendes NT, Ronchi NR, Silva GD
Cerebellum 2023 Dec;22(6):1287-1292. Epub 2022 Nov 5 doi: 10.1007/s12311-022-01492-3. PMID: 36334195
Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.
Fernandez L, Rogasch NC, Do M, Clark G, Major BP, Teo WP, Byrne LK, Enticott PG
Cerebellum 2020 Apr;19(2):309-335. doi: 10.1007/s12311-019-01093-7. PMID: 31907864
Pediatric Brain Development in Down Syndrome: A Field in Its Infancy.
Hamner T, Udhnani MD, Osipowicz KZ, Lee NR
J Int Neuropsychol Soc 2018 Oct;24(9):966-976. Epub 2018 May 23 doi: 10.1017/S1355617718000206. PMID: 29789029Free PMC Article
Deep brain and cortical stimulation for epilepsy.
Sprengers M, Vonck K, Carrette E, Marson AG, Boon P
Cochrane Database Syst Rev 2017 Jul 18;7(7):CD008497. doi: 10.1002/14651858.CD008497.pub3. PMID: 28718878Free PMC Article
Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis.
Smieskova R, Fusar-Poli P, Allen P, Bendfeldt K, Stieglitz RD, Drewe J, Radue EW, McGuire PK, Riecher-Rössler A, Borgwardt SJ
Neurosci Biobehav Rev 2010 Jul;34(8):1207-22. Epub 2010 Feb 6 doi: 10.1016/j.neubiorev.2010.01.016. PMID: 20144653

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