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Reduced radioactive iodine uptake

MedGen UID:
1624161
•Concept ID:
C4531269
•
Finding
HPO: HP:0031219

Definition

A decreased amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced radioactive iodine uptake

Professional guidelines

PubMed

Recombinant human TSH and radioactive iodine therapy in the management of benign multinodular goiter.
Graf H
Eur J Endocrinol 2015 Feb;172(2):R47-52. Epub 2014 Sep 4 doi: 10.1530/EJE-14-0608. PMID: 25189867
Lithium as an adjunct to radioactive iodine for the treatment of hyperthyroidism: a systematic review and meta-analysis.
Kessler L, Palla J, Baru JS, Onyenwenyi C, George AM, Lucas BP
Endocr Pract 2014 Jul;20(7):737-45. doi: 10.4158/EP13504.RA. PMID: 24793920
Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review.
Sawka AM, Ibrahim-Zada I, Galacgac P, Tsang RW, Brierley JD, Ezzat S, Goldstein DP
Thyroid 2010 Oct;20(10):1129-38. doi: 10.1089/thy.2010.0055. PMID: 20860420Free PMC Article

Recent clinical studies

Etiology

The Iodine Rush: Over- or Under-Iodination Risk in the Prophylactic Use of Iodine for Thyroid Blocking in the Event of a Nuclear Disaster.
Calcaterra V, Mameli C, Rossi V, Massini G, Gambino M, Baldassarre P, Zuccotti G
Front Endocrinol (Lausanne) 2022;13:901620. Epub 2022 May 26 doi: 10.3389/fendo.2022.901620. PMID: 35692388Free PMC Article
Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy.
Liu J, Liu Y, Lin Y, Liang J
Endocrinol Metab (Seoul) 2019 Sep;34(3):215-225. doi: 10.3803/EnM.2019.34.3.215. PMID: 31565873Free PMC Article
Effects and Role of Multikinase Inhibitors in Thyroid Cancer.
Laursen R, Wehland M, Kopp S, Pietsch J, Infanger M, Grosse J, Grimm D
Curr Pharm Des 2016;22(39):5915-5926. doi: 10.2174/1381612822666160614084943. PMID: 27306093
Recombinant human TSH and radioactive iodine therapy in the management of benign multinodular goiter.
Graf H
Eur J Endocrinol 2015 Feb;172(2):R47-52. Epub 2014 Sep 4 doi: 10.1530/EJE-14-0608. PMID: 25189867
Iodine deficiency and increased risk from radioactive iodine intake in nuclear medicine personnel.
Corrente A, Aprile C
G Ital Med Lav Ergon 2000 Apr-Jun;22(2):135-8. PMID: 10911555

Diagnosis

Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer.
Zhang L, Li Z, Zhang M, Zou H, Bai Y, Liu Y, Lv J, Lv L, Liu P, Deng Z, Liu C
Med Oncol 2023 Jul 31;40(9):258. doi: 10.1007/s12032-023-02098-3. PMID: 37524925
Recombinant human TSH and radioactive iodine therapy in the management of benign multinodular goiter.
Graf H
Eur J Endocrinol 2015 Feb;172(2):R47-52. Epub 2014 Sep 4 doi: 10.1530/EJE-14-0608. PMID: 25189867
Thyroiditis: an integrated approach.
Sweeney LB, Stewart C, Gaitonde DY
Am Fam Physician 2014 Sep 15;90(6):389-96. PMID: 25251231
Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review.
Sawka AM, Ibrahim-Zada I, Galacgac P, Tsang RW, Brierley JD, Ezzat S, Goldstein DP
Thyroid 2010 Oct;20(10):1129-38. doi: 10.1089/thy.2010.0055. PMID: 20860420Free PMC Article
Thyroiditis.
Bindra A, Braunstein GD
Am Fam Physician 2006 May 15;73(10):1769-76. PMID: 16734054

Therapy

Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer.
Zhang L, Li Z, Zhang M, Zou H, Bai Y, Liu Y, Lv J, Lv L, Liu P, Deng Z, Liu C
Med Oncol 2023 Jul 31;40(9):258. doi: 10.1007/s12032-023-02098-3. PMID: 37524925
Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy.
Liu J, Liu Y, Lin Y, Liang J
Endocrinol Metab (Seoul) 2019 Sep;34(3):215-225. doi: 10.3803/EnM.2019.34.3.215. PMID: 31565873Free PMC Article
Thyroiditis: an integrated approach.
Sweeney LB, Stewart C, Gaitonde DY
Am Fam Physician 2014 Sep 15;90(6):389-96. PMID: 25251231
Thyroiditis.
Bindra A, Braunstein GD
Am Fam Physician 2006 May 15;73(10):1769-76. PMID: 16734054
Radioiodine therapy and thyrostatic drugs and iodine.
Moka D, Dietlein M, Schicha H
Eur J Nucl Med Mol Imaging 2002 Aug;29 Suppl 2:S486-91. Epub 2002 Jun 27 doi: 10.1007/s00259-002-0868-4. PMID: 12192550

Prognosis

Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer.
Zhang L, Li Z, Zhang M, Zou H, Bai Y, Liu Y, Lv J, Lv L, Liu P, Deng Z, Liu C
Med Oncol 2023 Jul 31;40(9):258. doi: 10.1007/s12032-023-02098-3. PMID: 37524925
Bone metastases from differentiated thyroid carcinoma: heterogenous tumor response to radioactive Iodine therapy and overall survival.
Jannin A, Lamartina L, Moutarde C, Djennaoui M, Lion G, Chevalier B, Vantyghem MC, Deschamps F, Hadoux J, Baudin E, Schlumberger M, Leboulleux S, Do Cao C
Eur J Nucl Med Mol Imaging 2022 Jun;49(7):2401-2413. Epub 2022 Feb 12 doi: 10.1007/s00259-022-05697-w. PMID: 35149914Free PMC Article
Thyroiditis: an integrated approach.
Sweeney LB, Stewart C, Gaitonde DY
Am Fam Physician 2014 Sep 15;90(6):389-96. PMID: 25251231
PET/CT imaging of thyroid cancer.
Mosci C, Iagaru A
Clin Nucl Med 2011 Dec;36(12):e180-5. doi: 10.1097/RLU.0b013e3182291d03. PMID: 22064103
Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.
Kogai T, Taki K, Brent GA
Endocr Relat Cancer 2006 Sep;13(3):797-826. doi: 10.1677/erc.1.01143. PMID: 16954431

Clinical prediction guides

Organic cation transporter 3 mediates the non-norepinephrine transporter driven uptake of meta-[(211)At]astato-benzylguanidine.
Ohshima Y, Sasaki I, Watanabe S, Sakashita T, Higashi T, Ishioka NS
Nucl Med Biol 2022 Sep-Oct;112-113:44-51. Epub 2022 Jun 30 doi: 10.1016/j.nucmedbio.2022.06.005. PMID: 35802985
Bone metastases from differentiated thyroid carcinoma: heterogenous tumor response to radioactive Iodine therapy and overall survival.
Jannin A, Lamartina L, Moutarde C, Djennaoui M, Lion G, Chevalier B, Vantyghem MC, Deschamps F, Hadoux J, Baudin E, Schlumberger M, Leboulleux S, Do Cao C
Eur J Nucl Med Mol Imaging 2022 Jun;49(7):2401-2413. Epub 2022 Feb 12 doi: 10.1007/s00259-022-05697-w. PMID: 35149914Free PMC Article
Recombinant human TSH and radioactive iodine therapy in the management of benign multinodular goiter.
Graf H
Eur J Endocrinol 2015 Feb;172(2):R47-52. Epub 2014 Sep 4 doi: 10.1530/EJE-14-0608. PMID: 25189867
Lithium as an adjunct to radioactive iodine for the treatment of hyperthyroidism: a systematic review and meta-analysis.
Kessler L, Palla J, Baru JS, Onyenwenyi C, George AM, Lucas BP
Endocr Pract 2014 Jul;20(7):737-45. doi: 10.4158/EP13504.RA. PMID: 24793920
Sorafenib: rays of hope in thyroid cancer.
Duntas LH, Bernardini R
Thyroid 2010 Dec;20(12):1351-8. Epub 2010 Oct 18 doi: 10.1089/thy.2010.0056. PMID: 20954817

Recent systematic reviews

Lithium as an adjunct to radioactive iodine for the treatment of hyperthyroidism: a systematic review and meta-analysis.
Kessler L, Palla J, Baru JS, Onyenwenyi C, George AM, Lucas BP
Endocr Pract 2014 Jul;20(7):737-45. doi: 10.4158/EP13504.RA. PMID: 24793920
Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review.
Sawka AM, Ibrahim-Zada I, Galacgac P, Tsang RW, Brierley JD, Ezzat S, Goldstein DP
Thyroid 2010 Oct;20(10):1129-38. doi: 10.1089/thy.2010.0055. PMID: 20860420Free PMC Article

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