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Abnormal CD25 upregulation upon TCR activation

MedGen UID:
1624217
•Concept ID:
C4531235
•
Cell or Molecular Dysfunction
HPO: HP:0031269

Definition

Any abnormality in the upregulation of CD25 on T cells after activation via the T cell receptor (TCR). CD25 is the alpha chain of the IL2 receptor. Ligation of the T cell antigen receptor leads to the induction of CD25 expression. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal CD25 upregulation upon TCR activation

Recent clinical studies

Etiology

In vitro engagement of CD3 and CD28 corrects T cell defects in chronic lymphocytic leukemia.
Bonyhadi M, Frohlich M, Rasmussen A, Ferrand C, Grosmaire L, Robinet E, Leis J, Maziarz RT, Tiberghien P, Berenson RJ
J Immunol 2005 Feb 15;174(4):2366-75. doi: 10.4049/jimmunol.174.4.2366. PMID: 15699173

Therapy

In vitro engagement of CD3 and CD28 corrects T cell defects in chronic lymphocytic leukemia.
Bonyhadi M, Frohlich M, Rasmussen A, Ferrand C, Grosmaire L, Robinet E, Leis J, Maziarz RT, Tiberghien P, Berenson RJ
J Immunol 2005 Feb 15;174(4):2366-75. doi: 10.4049/jimmunol.174.4.2366. PMID: 15699173

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