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Reduced MHC II surface expression

MedGen UID:
1625904
•Concept ID:
C4531158
•
Cell or Molecular Dysfunction
HPO: HP:0031390

Definition

A reduction from the normal level of major histocompatibility complex class II molecules expressed at the cell surface. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced MHC II surface expression

Professional guidelines

PubMed

Short term statin treatment improves survival and differentially regulates macrophage-mediated responses to Staphylococcus aureus.
Burns EM, Smelser LK, Then JE, Stankiewicz TE, Kushdilian M, McDowell SA, Bruns HA
Curr Pharm Biotechnol 2013;14(2):233-41. doi: 10.2174/138920113805219395. PMID: 23228241Free PMC Article
Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1.
Zhao D, Amria S, Hossain A, Sundaram K, Komlosi P, Nagarkatti M, Haque A
Cell Immunol 2011;271(2):392-400. Epub 2011 Aug 18 doi: 10.1016/j.cellimm.2011.08.007. PMID: 21903207Free PMC Article
Virus-specific cytotoxic CD4+ T cells for the treatment of EBV-related tumors.
Merlo A, Turrini R, Bobisse S, Zamarchi R, Alaggio R, Dolcetti R, Mautner J, Zanovello P, Amadori A, Rosato A
J Immunol 2010 May 15;184(10):5895-902. Epub 2010 Apr 12 doi: 10.4049/jimmunol.0902850. PMID: 20385879

Recent clinical studies

Etiology

Immune checkpoint inhibitors and reproductive failures.
Chen Z, Huang J, Kwak-Kim J, Wang W
J Reprod Immunol 2023 Mar;156:103799. Epub 2023 Jan 13 doi: 10.1016/j.jri.2023.103799. PMID: 36724630
Increased expression of TIGIT and KLRG1 correlates with impaired CD56(bright) NK cell immunity in HPV16-related cervical intraepithelial neoplasia.
Nie Y, Liu D, Yang W, Li Y, Zhang L, Cheng X, Chen R, Yuan B, Zhang G, Wang H
Virol J 2022 Apr 12;19(1):68. doi: 10.1186/s12985-022-01776-4. PMID: 35413989Free PMC Article
Non-classical monocytes and its potential in diagnosing sepsis post cardiac surgery.
Sebastian A, Sanju S, Jain P, Priya VV, Varma PK, Mony U
Int Immunopharmacol 2021 Oct;99:108037. Epub 2021 Aug 10 doi: 10.1016/j.intimp.2021.108037. PMID: 34426113
Neuropeptide Y mediates cardiac hypertrophy through microRNA-216b/FoxO4 signaling pathway.
Wang J, Hao D, Zeng L, Zhang Q, Huang W
Int J Med Sci 2021;18(1):18-28. Epub 2021 Jan 1 doi: 10.7150/ijms.51133. PMID: 33390770Free PMC Article
Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent.
Mohammadi A, Blesso CN, Barreto GE, Banach M, Majeed M, Sahebkar A
J Nutr Biochem 2019 Apr;66:1-16. Epub 2018 Dec 21 doi: 10.1016/j.jnutbio.2018.12.005. PMID: 30660832

Diagnosis

Non-classical monocytes and its potential in diagnosing sepsis post cardiac surgery.
Sebastian A, Sanju S, Jain P, Priya VV, Varma PK, Mony U
Int Immunopharmacol 2021 Oct;99:108037. Epub 2021 Aug 10 doi: 10.1016/j.intimp.2021.108037. PMID: 34426113
Mapping and IgE-binding capacity analysis of heat/digested stable epitopes of mud crab allergens.
Liu M, Huan F, Li M, Han T, Xia F, Yang Y, Liu Q, Chen G, Cao M, Liu G
Food Chem 2021 May 15;344:128735. Epub 2020 Nov 28 doi: 10.1016/j.foodchem.2020.128735. PMID: 33279350
Pronase treatment improves flow cytometry crossmatching results.
Apithy MJ, Desoutter J, Gicquel A, Guiheneuf E, Westeel PF, Lesage A, Piot V, Choukroun G, Guillaume N
HLA 2017 Sep;90(3):157-164. Epub 2017 Jun 28 doi: 10.1111/tan.13073. PMID: 28660746
Mode of action of botulinum neurotoxins: current vaccination strategies and molecular immune recognition.
Aoki KR, Smith LA, Atassi MZ
Crit Rev Immunol 2010;30(2):167-87. doi: 10.1615/critrevimmunol.v30.i2.50. PMID: 20370628
Expression of class I and II MHC receptors in Helicobacter pylori-positive patients with active gastritis and duodenal ulcer.
Suleymanov Z
Turk J Gastroenterol 2003 Sep;14(3):168-72. PMID: 14655059

Therapy

PD-1 blockade in combination with dasatinib potentiates induction of anti-acute lymphocytic leukemia immunity.
Koller P, Baran N, Harutyunyan K, Cavazos A, Mallampati S, Chin RL, Jiang Z, Sun X, Lee HH, Hsu JL, Williams P, Huang X, Curran MA, Hung MC, Konopleva M
J Immunother Cancer 2023 Oct;11(10) doi: 10.1136/jitc-2022-006619. PMID: 37793852Free PMC Article
Immune checkpoint inhibitors and reproductive failures.
Chen Z, Huang J, Kwak-Kim J, Wang W
J Reprod Immunol 2023 Mar;156:103799. Epub 2023 Jan 13 doi: 10.1016/j.jri.2023.103799. PMID: 36724630
Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy.
Fernando R, Caldera O, Smith TJ
Proc Natl Acad Sci U S A 2021 Dec 28;118(52) doi: 10.1073/pnas.2114244118. PMID: 34949642Free PMC Article
Pronase treatment improves flow cytometry crossmatching results.
Apithy MJ, Desoutter J, Gicquel A, Guiheneuf E, Westeel PF, Lesage A, Piot V, Choukroun G, Guillaume N
HLA 2017 Sep;90(3):157-164. Epub 2017 Jun 28 doi: 10.1111/tan.13073. PMID: 28660746
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects.
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows GG, Bourdette D, Offner H, Bucala R, Vandenbark AA
Eur J Immunol 2013 May;43(5):1309-21. Epub 2013 Apr 10 doi: 10.1002/eji.201243162. PMID: 23576302Free PMC Article

Prognosis

FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
Kasuga Y, Ouda R, Watanabe M, Sun X, Kimura M, Hatakeyama S, Kobayashi KS
Proc Natl Acad Sci U S A 2023 Jun 13;120(24):e2218955120. Epub 2023 Jun 6 doi: 10.1073/pnas.2218955120. PMID: 37279268Free PMC Article
SESLA suppresses the activation of macrophages and dendritic cells after Gram-positive bacterial challenge.
Jiang X, Xu Y, Xiang T, Zhang H, Cheng X, Yang XD, Hu H, Jiang X, Zheng Y
Immunopharmacol Immunotoxicol 2023 Apr;45(2):213-223. Epub 2022 Oct 26 doi: 10.1080/08923973.2022.2134790. PMID: 36218392
Increased expression of TIGIT and KLRG1 correlates with impaired CD56(bright) NK cell immunity in HPV16-related cervical intraepithelial neoplasia.
Nie Y, Liu D, Yang W, Li Y, Zhang L, Cheng X, Chen R, Yuan B, Zhang G, Wang H
Virol J 2022 Apr 12;19(1):68. doi: 10.1186/s12985-022-01776-4. PMID: 35413989Free PMC Article
Non-classical monocytes and its potential in diagnosing sepsis post cardiac surgery.
Sebastian A, Sanju S, Jain P, Priya VV, Varma PK, Mony U
Int Immunopharmacol 2021 Oct;99:108037. Epub 2021 Aug 10 doi: 10.1016/j.intimp.2021.108037. PMID: 34426113
FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
Brown PJ, Wong KK, Felce SL, Lyne L, Spearman H, Soilleux EJ, Pedersen LM, Møller MB, Green TM, Gascoyne DM, Banham AH
Leukemia 2016 Mar;30(3):605-16. Epub 2015 Oct 26 doi: 10.1038/leu.2015.299. PMID: 26500140Free PMC Article

Clinical prediction guides

LAMTOR1 degrades MHC-II via the endocytic in hepatocellular carcinoma.
Wu B, Wang Q, Li B, Jiang M
Carcinogenesis 2022 Dec 25;43(11):1059-1070. doi: 10.1093/carcin/bgac075. PMID: 36070764Free PMC Article
Increased expression of TIGIT and KLRG1 correlates with impaired CD56(bright) NK cell immunity in HPV16-related cervical intraepithelial neoplasia.
Nie Y, Liu D, Yang W, Li Y, Zhang L, Cheng X, Chen R, Yuan B, Zhang G, Wang H
Virol J 2022 Apr 12;19(1):68. doi: 10.1186/s12985-022-01776-4. PMID: 35413989Free PMC Article
Non-classical monocytes and its potential in diagnosing sepsis post cardiac surgery.
Sebastian A, Sanju S, Jain P, Priya VV, Varma PK, Mony U
Int Immunopharmacol 2021 Oct;99:108037. Epub 2021 Aug 10 doi: 10.1016/j.intimp.2021.108037. PMID: 34426113
Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy.
Rudulier CD, Tonti E, James E, Kwok WW, Larché M
Allergy 2019 Nov;74(11):2157-2166. Epub 2019 Jun 7 doi: 10.1111/all.13867. PMID: 31077596Free PMC Article
Lymphocyte-melanoma interaction: role of surface molecules.
Becker JC, Bröcker EB
Recent Results Cancer Res 1995;139:205-14. doi: 10.1007/978-3-642-78771-3_15. PMID: 7597291

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