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Myocardial eosinophilic infiltration

MedGen UID:
1626088
•Concept ID:
C4531200
•
Finding
HPO: HP:0031323

Definition

An increase in the number of eosinophils in myocardial tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial eosinophilic infiltration

Conditions with this feature

Familial eosinophilia
MedGen UID:
78796
•Concept ID:
C0272192
•
Disease or Syndrome
Familial eosinophilia is a rare autosomal dominant disorder characterized by peripheral hypereosinophilia (greater than 500 eosinophils/micro liter of blood) with or without other oragn involvement (summary by Rioux et al., 1998).
See: Condition Record
Familial eosinophilia

Professional guidelines

PubMed

Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Kounis syndrome: A review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome.
Abdelghany M, Subedi R, Shah S, Kozman H
Int J Cardiol 2017 Apr 1;232:1-4. Epub 2017 Jan 27 doi: 10.1016/j.ijcard.2017.01.124. PMID: 28153536
Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management.
Kounis NG
Clin Chem Lab Med 2016 Oct 1;54(10):1545-59. doi: 10.1515/cclm-2016-0010. PMID: 26966931

Recent clinical studies

Etiology

Cardiac involvement in eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): Prospective evaluation at a tertiary referral centre.
Zampieri M, Emmi G, Beltrami M, Fumagalli C, Urban ML, Dei LL, Marchi A, Berteotti M, Tomberli A, Baldini K, Bettiol A, Pradella S, Silvestri E, Marchionni N, Vaglio A, Olivotto I, Prisco D
Eur J Intern Med 2021 Mar;85:68-79. Epub 2020 Dec 23 doi: 10.1016/j.ejim.2020.12.008. PMID: 33358337
Characteristics of patients with advanced heart failure having eosinophilic infiltration of the myocardium in the recent era.
Yoshizawa S, Sugiyama Kato T, Mancini D, C Marboe C
Int Heart J 2013;54(3):146-8. doi: 10.1536/ihj.54.146. PMID: 23774237
QT dispersion in patients with Churg-Strauss syndrome.
Szczeklik W, Sokołowska BM, Mastalerz L, Miszalski-Jamka T, Pacult K, Górka J, Musiał J
Kardiol Pol 2011;69(11):1143-9. PMID: 22090223
Persistent eosinophilic infiltration of the myocardium in a child in complete remission of acute lymphoblastic leukemia and eosinophilia. Potential role in late cardiac disease?
Tsuji A, Sasaki M, Ishii T, Sato S, Kanki H, Suzuki S, Takeuchi S, Fukuda T
Keio J Med 2010;59(2):64-8. doi: 10.2302/kjm.59.64. PMID: 20601842

Diagnosis

Fulminant Eosinophilic Myocarditis Without Peripheral Eosinophilia.
Lee JY, Lee SH, Kim WH
Tex Heart Inst J 2023 Mar 1;50(2) doi: 10.14503/THIJ-21-7818. PMID: 37044058Free PMC Article
Cardiac involvement in eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): Prospective evaluation at a tertiary referral centre.
Zampieri M, Emmi G, Beltrami M, Fumagalli C, Urban ML, Dei LL, Marchi A, Berteotti M, Tomberli A, Baldini K, Bettiol A, Pradella S, Silvestri E, Marchionni N, Vaglio A, Olivotto I, Prisco D
Eur J Intern Med 2021 Mar;85:68-79. Epub 2020 Dec 23 doi: 10.1016/j.ejim.2020.12.008. PMID: 33358337
Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature.
Chaudhry MA, Grazette L, Yoon A, Correa A, Fong MW
Curr Hypertens Rev 2019;15(1):8-12. doi: 10.2174/1573402114666180903164900. PMID: 30179138
Characteristics of patients with advanced heart failure having eosinophilic infiltration of the myocardium in the recent era.
Yoshizawa S, Sugiyama Kato T, Mancini D, C Marboe C
Int Heart J 2013;54(3):146-8. doi: 10.1536/ihj.54.146. PMID: 23774237
QT dispersion in patients with Churg-Strauss syndrome.
Szczeklik W, Sokołowska BM, Mastalerz L, Miszalski-Jamka T, Pacult K, Górka J, Musiał J
Kardiol Pol 2011;69(11):1143-9. PMID: 22090223

Therapy

Fulminant Eosinophilic Myocarditis Without Peripheral Eosinophilia.
Lee JY, Lee SH, Kim WH
Tex Heart Inst J 2023 Mar 1;50(2) doi: 10.14503/THIJ-21-7818. PMID: 37044058Free PMC Article
Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature.
Chaudhry MA, Grazette L, Yoon A, Correa A, Fong MW
Curr Hypertens Rev 2019;15(1):8-12. doi: 10.2174/1573402114666180903164900. PMID: 30179138
Characteristics of patients with advanced heart failure having eosinophilic infiltration of the myocardium in the recent era.
Yoshizawa S, Sugiyama Kato T, Mancini D, C Marboe C
Int Heart J 2013;54(3):146-8. doi: 10.1536/ihj.54.146. PMID: 23774237

Prognosis

Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature.
Chaudhry MA, Grazette L, Yoon A, Correa A, Fong MW
Curr Hypertens Rev 2019;15(1):8-12. doi: 10.2174/1573402114666180903164900. PMID: 30179138
Characteristics of patients with advanced heart failure having eosinophilic infiltration of the myocardium in the recent era.
Yoshizawa S, Sugiyama Kato T, Mancini D, C Marboe C
Int Heart J 2013;54(3):146-8. doi: 10.1536/ihj.54.146. PMID: 23774237
Persistent eosinophilic infiltration of the myocardium in a child in complete remission of acute lymphoblastic leukemia and eosinophilia. Potential role in late cardiac disease?
Tsuji A, Sasaki M, Ishii T, Sato S, Kanki H, Suzuki S, Takeuchi S, Fukuda T
Keio J Med 2010;59(2):64-8. doi: 10.2302/kjm.59.64. PMID: 20601842

Clinical prediction guides

Characteristics of patients with advanced heart failure having eosinophilic infiltration of the myocardium in the recent era.
Yoshizawa S, Sugiyama Kato T, Mancini D, C Marboe C
Int Heart J 2013;54(3):146-8. doi: 10.1536/ihj.54.146. PMID: 23774237
QT dispersion in patients with Churg-Strauss syndrome.
Szczeklik W, Sokołowska BM, Mastalerz L, Miszalski-Jamka T, Pacult K, Górka J, Musiał J
Kardiol Pol 2011;69(11):1143-9. PMID: 22090223

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