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Liver Stiffness

MedGen UID:
1627445
Concept ID:
C4034374
Finding

Definition

The modulus of elasticity of the liver, representing the resistance of the liver to deformation. Liver stiffness has been shown to be a surrogate marker of advanced fibrosis and cirrhosis. Liver stiffness, measured by transient elastography, is an independent predictor of liver failure, hepatocellular carcinoma, and mortality in cirrhotic patients coinfected with the human immunodeficiency virus or acquired immune deficiency syndrome, and hepatitis C virus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Stiffness

Professional guidelines

PubMed

Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Gralnek IM, Camus Duboc M, Garcia-Pagan JC, Fuccio L, Karstensen JG, Hucl T, Jovanovic I, Awadie H, Hernandez-Gea V, Tantau M, Ebigbo A, Ibrahim M, Vlachogiannakos J, Burgmans MC, Rosasco R, Triantafyllou K
Endoscopy 2022 Nov;54(11):1094-1120. Epub 2022 Sep 29 doi: 10.1055/a-1939-4887. PMID: 36174643
Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M, Cavo M, Colecchia A
Front Immunol 2020;11:489. Epub 2020 Apr 3 doi: 10.3389/fimmu.2020.00489. PMID: 32318059Free PMC Article

Recent clinical studies

Etiology

Bandyopadhyay S, Das S, Samajdar SS, Joshi SR
Diabetes Metab Syndr 2023 Oct;17(10):102849. Epub 2023 Sep 13 doi: 10.1016/j.dsx.2023.102849. PMID: 37717295
Atallah E, Grove JI, Crooks C, Burden-Teh E, Abhishek A, Moreea S, Jordan KM, Ala A, Hutchinson D, Aspinall RJ, Murphy R, Aithal GP
J Hepatol 2023 May;78(5):989-997. Epub 2023 Jan 23 doi: 10.1016/j.jhep.2022.12.034. PMID: 36702175
Bednář O, Dvořák K
Cas Lek Cesk 2022 Spring;161(2):61-64. PMID: 35728959
Mauro E, Gadano A
Liver Int 2020 Feb;40 Suppl 1:122-127. doi: 10.1111/liv.14366. PMID: 32077610
de Lédinghen V, Vergniol J
Gastroenterol Clin Biol 2008 Sep;32(6 Suppl 1):58-67. doi: 10.1016/S0399-8320(08)73994-0. PMID: 18973847

Diagnosis

Atallah E, Grove JI, Crooks C, Burden-Teh E, Abhishek A, Moreea S, Jordan KM, Ala A, Hutchinson D, Aspinall RJ, Murphy R, Aithal GP
J Hepatol 2023 May;78(5):989-997. Epub 2023 Jan 23 doi: 10.1016/j.jhep.2022.12.034. PMID: 36702175
Bednář O, Dvořák K
Cas Lek Cesk 2022 Spring;161(2):61-64. PMID: 35728959
Ferraioli G, Barr RG
World J Gastroenterol 2020 Jun 28;26(24):3413-3420. doi: 10.3748/wjg.v26.i24.3413. PMID: 32655265Free PMC Article
Mauro E, Gadano A
Liver Int 2020 Feb;40 Suppl 1:122-127. doi: 10.1111/liv.14366. PMID: 32077610
de Lédinghen V, Vergniol J
Gastroenterol Clin Biol 2008 Sep;32(6 Suppl 1):58-67. doi: 10.1016/S0399-8320(08)73994-0. PMID: 18973847

Therapy

Harrison SA, Taub R, Neff GW, Lucas KJ, Labriola D, Moussa SE, Alkhouri N, Bashir MR
Nat Med 2023 Nov;29(11):2919-2928. Epub 2023 Oct 16 doi: 10.1038/s41591-023-02603-1. PMID: 37845512Free PMC Article
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Haigh L, Kirk C, El Gendy K, Gallacher J, Errington L, Mathers JC, Anstee QM
Clin Nutr 2022 Sep;41(9):1913-1931. Epub 2022 Jul 2 doi: 10.1016/j.clnu.2022.06.037. PMID: 35947894
Cunha GM, Guzman G, Correa De Mello LL, Trein B, Spina L, Bussade I, Marques Prata J, Sajoux I, Countinho W
Front Endocrinol (Lausanne) 2020;11:607. Epub 2020 Sep 14 doi: 10.3389/fendo.2020.00607. PMID: 33042004Free PMC Article
Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M, Cavo M, Colecchia A
Front Immunol 2020;11:489. Epub 2020 Apr 3 doi: 10.3389/fimmu.2020.00489. PMID: 32318059Free PMC Article

Prognosis

Corpechot C, Carrat F, Gaouar F, Chau F, Hirschfield G, Gulamhusein A, Montano-Loza AJ, Lytvyak E, Schramm C, Pares A, Olivas I, Eaton JE, Osman KT, Dalekos G, Gatselis N, Nevens F, Cazzagon N, Zago A, Russo FP, Abbas N, Trivedi P, Thorburn D, Saffioti F, Barkai L, Roccarina D, Calvaruso V, Fichera A, Delamarre A, Medina-Morales E, Bonder A, Patwardhan V, Rigamonti C, Carbone M, Invernizzi P, Cristoferi L, van der Meer A, de Veer R, Zigmond E, Yehezkel E, Kremer AE, Deibel A, Dumortier J, Bruns T, Große K, Pageaux GP, Wetten A, Dyson J, Jones D, Chazouillères O, Hansen B, de Lédinghen V; Global & ERN Rare-Liver PBC Study Groups
J Hepatol 2022 Dec;77(6):1545-1553. Epub 2022 Jun 28 doi: 10.1016/j.jhep.2022.06.017. PMID: 35777587
Ferraioli G, Barr RG
World J Gastroenterol 2020 Jun 28;26(24):3413-3420. doi: 10.3748/wjg.v26.i24.3413. PMID: 32655265Free PMC Article
Guglielmo FF, Venkatesh SK, Mitchell DG
Radiographics 2019 Nov-Dec;39(7):1983-2002. Epub 2019 Oct 18 doi: 10.1148/rg.2019190034. PMID: 31626569
Hagan M, Asrani SK, Talwalkar J
Expert Rev Gastroenterol Hepatol 2015;9(10):1251-60. doi: 10.1586/17474124.2015.1075391. PMID: 26377444
Asrani SK, Kamath PS
Curr Gastroenterol Rep 2013 Feb;15(2):308. doi: 10.1007/s11894-012-0308-y. PMID: 23314828

Clinical prediction guides

Noureddin M, Truong E, Mayo R, Martínez-Arranz I, Mincholé I, Banales JM, Arrese M, Cusi K, Arias-Loste MT, Bruha R, Romero-Gómez M, Iruzubieta P, Aller R, Ampuero J, Calleja JL, Ibañez-Samaniego L, Aspichueta P, Martín-Duce A, Kushner T, Ortiz P, Harrison SA, Anstee QM, Crespo J, Mato JM, Sanyal AJ
Hepatology 2024 Jan 1;79(1):135-148. Epub 2023 Jul 24 doi: 10.1097/HEP.0000000000000542. PMID: 37505221Free PMC Article
Chang D, Truong E, Mena EA, Pacheco F, Wong M, Guindi M, Todo TT, Noureddin N, Ayoub W, Yang JD, Kim IK, Kohli A, Alkhouri N, Harrison S, Noureddin M
Hepatology 2023 Feb 1;77(2):546-557. Epub 2022 Aug 9 doi: 10.1002/hep.32655. PMID: 35809234
Pons M, Augustin S, Scheiner B, Guillaume M, Rosselli M, Rodrigues SG, Stefanescu H, Ma MM, Mandorfer M, Mergeay-Fabre M, Procopet B, Schwabl P, Ferlitsch A, Semmler G, Berzigotti A, Tsochatzis E, Bureau C, Reiberger T, Bosch J, Abraldes JG, Genescà J
Am J Gastroenterol 2021 Apr;116(4):723-732. doi: 10.14309/ajg.0000000000000994. PMID: 33982942
Newsome PN, Sasso M, Deeks JJ, Paredes A, Boursier J, Chan WK, Yilmaz Y, Czernichow S, Zheng MH, Wong VW, Allison M, Tsochatzis E, Anstee QM, Sheridan DA, Eddowes PJ, Guha IN, Cobbold JF, Paradis V, Bedossa P, Miette V, Fournier-Poizat C, Sandrin L, Harrison SA
Lancet Gastroenterol Hepatol 2020 Apr;5(4):362-373. Epub 2020 Feb 3 doi: 10.1016/S2468-1253(19)30383-8. PMID: 32027858Free PMC Article
Eddowes PJ, Sasso M, Allison M, Tsochatzis E, Anstee QM, Sheridan D, Guha IN, Cobbold JF, Deeks JJ, Paradis V, Bedossa P, Newsome PN
Gastroenterology 2019 May;156(6):1717-1730. Epub 2019 Jan 25 doi: 10.1053/j.gastro.2019.01.042. PMID: 30689971

Recent systematic reviews

Bandyopadhyay S, Das S, Samajdar SS, Joshi SR
Diabetes Metab Syndr 2023 Oct;17(10):102849. Epub 2023 Sep 13 doi: 10.1016/j.dsx.2023.102849. PMID: 37717295
Del Bo' C, Perna S, Allehdan S, Rafique A, Saad S, AlGhareeb F, Rondanelli M, Tayyem RF, Marino M, Martini D, Riso P
Nutrients 2023 May 9;15(10) doi: 10.3390/nu15102250. PMID: 37242133Free PMC Article
Yang K, Chen J, Zhang T, Yuan X, Ge A, Wang S, Xu H, Zeng L, Ge J
Front Immunol 2022;13:949746. Epub 2022 Sep 9 doi: 10.3389/fimmu.2022.949746. PMID: 36159792Free PMC Article
Haigh L, Kirk C, El Gendy K, Gallacher J, Errington L, Mathers JC, Anstee QM
Clin Nutr 2022 Sep;41(9):1913-1931. Epub 2022 Jul 2 doi: 10.1016/j.clnu.2022.06.037. PMID: 35947894
Selvaraj EA, Mózes FE, Jayaswal ANA, Zafarmand MH, Vali Y, Lee JA, Levick CK, Young LAJ, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators
J Hepatol 2021 Oct;75(4):770-785. Epub 2021 May 13 doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635

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