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Metastatic Lung Squamous Cell Carcinoma

MedGen UID:
163176
•Concept ID:
C0854994
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the lung and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Prognostic impact of metastatic patterns and treatment modalities on overall survival in lung squamous cell carcinoma: A population-based study.
Qin L, Yu X, Xu C, Liu Y
Medicine (Baltimore) 2023 Jul 21;102(29):e34251. doi: 10.1097/MD.0000000000034251. PMID: 37478210Free PMC Article

Recent clinical studies

Etiology

Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study.
Liu Y, Sun M, Xiong Y, Gu X, Zhang K, Liu L
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221132035. doi: 10.1177/15330338221132035. PMID: 36217877Free PMC Article
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study.
Zhang J, Pan Y, Shi Q, Zhang G, Jiang L, Dong X, Gu K, Wang H, Zhang X, Yang N, Li Y, Xiong J, Yi T, Peng M, Song Y, Fan Y, Cui J, Chen G, Tan W, Zang A, Guo Q, Zhao G, Wang Z, He J, Yao W, Wu X, Chen K, Hu X, Hu C, Yue L, Jiang D, Wang G, Liu J, Yu G, Li J, Bai J, Xie W, Zhao W, Wu L, Zhou C
Cancer Commun (Lond) 2022 Jan;42(1):3-16. Epub 2021 Oct 26 doi: 10.1002/cac2.12225. PMID: 34699693Free PMC Article
Influence of different drug delivery methods for Endostar combined with a gemcitabine/cisplatin regimen in locally advanced or metastatic lung squamous cell carcinoma: A retrospective observational study.
Yao D, Shen H, Huang J, Yuan Y, Dai H
Medicine (Baltimore) 2018 Aug;97(32):e11822. doi: 10.1097/MD.0000000000011822. PMID: 30095656Free PMC Article
Lung-MAP--framework, overview, and design principles.
Ferrarotto R, Redman MW, Gandara DR, Herbst RS, Papadimitrakopoulou VA
Chin Clin Oncol 2015 Sep;4(3):36. doi: 10.3978/j.issn.2304-3865.2015.09.02. PMID: 26408303

Diagnosis

Prognostic impact of metastatic patterns and treatment modalities on overall survival in lung squamous cell carcinoma: A population-based study.
Qin L, Yu X, Xu C, Liu Y
Medicine (Baltimore) 2023 Jul 21;102(29):e34251. doi: 10.1097/MD.0000000000034251. PMID: 37478210Free PMC Article
Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study.
Liu Y, Sun M, Xiong Y, Gu X, Zhang K, Liu L
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221132035. doi: 10.1177/15330338221132035. PMID: 36217877Free PMC Article
Abscopal effect induced by modulated radiation therapy and pembrolizumab in a patient with pancreatic metastatic lung squamous cell carcinoma.
Wang W, Huang C, Wu S, Liu Z, Liu L, Li L, Li S
Thorac Cancer 2020 Jul;11(7):2014-2017. Epub 2020 May 11 doi: 10.1111/1759-7714.13427. PMID: 32391640Free PMC Article
Diffuse edema suggestive of cytokine release syndrome in a metastatic lung carcinoma patient treated with pembrolizumab.
Rassy EE, Assi T, Rizkallah J, Kattan J
Immunotherapy 2017 Mar;9(4):309-311. doi: 10.2217/imt-2016-0134. PMID: 28303768
Lung-MAP--framework, overview, and design principles.
Ferrarotto R, Redman MW, Gandara DR, Herbst RS, Papadimitrakopoulou VA
Chin Clin Oncol 2015 Sep;4(3):36. doi: 10.3978/j.issn.2304-3865.2015.09.02. PMID: 26408303

Therapy

Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study.
Zhang J, Pan Y, Shi Q, Zhang G, Jiang L, Dong X, Gu K, Wang H, Zhang X, Yang N, Li Y, Xiong J, Yi T, Peng M, Song Y, Fan Y, Cui J, Chen G, Tan W, Zang A, Guo Q, Zhao G, Wang Z, He J, Yao W, Wu X, Chen K, Hu X, Hu C, Yue L, Jiang D, Wang G, Liu J, Yu G, Li J, Bai J, Xie W, Zhao W, Wu L, Zhou C
Cancer Commun (Lond) 2022 Jan;42(1):3-16. Epub 2021 Oct 26 doi: 10.1002/cac2.12225. PMID: 34699693Free PMC Article
The Current Landscape of Immune Checkpoint Blockade in Metastatic Lung Squamous Cell Carcinoma.
Yuan H, Liu J, Zhang J
Molecules 2021 Mar 5;26(5) doi: 10.3390/molecules26051392. PMID: 33807509Free PMC Article
Abscopal effect induced by modulated radiation therapy and pembrolizumab in a patient with pancreatic metastatic lung squamous cell carcinoma.
Wang W, Huang C, Wu S, Liu Z, Liu L, Li L, Li S
Thorac Cancer 2020 Jul;11(7):2014-2017. Epub 2020 May 11 doi: 10.1111/1759-7714.13427. PMID: 32391640Free PMC Article
Aortic dissection in a patient treated with anlotinib for metastatic lung squamous cell carcinoma.
Jiang B, Li J, Chen J, Xiang X, Xiong J, Deng J
Thorac Cancer 2020 Feb;11(2):461-464. Epub 2019 Dec 31 doi: 10.1111/1759-7714.13288. PMID: 31891239Free PMC Article
Lung-MAP--framework, overview, and design principles.
Ferrarotto R, Redman MW, Gandara DR, Herbst RS, Papadimitrakopoulou VA
Chin Clin Oncol 2015 Sep;4(3):36. doi: 10.3978/j.issn.2304-3865.2015.09.02. PMID: 26408303

Prognosis

Prognostic impact of metastatic patterns and treatment modalities on overall survival in lung squamous cell carcinoma: A population-based study.
Qin L, Yu X, Xu C, Liu Y
Medicine (Baltimore) 2023 Jul 21;102(29):e34251. doi: 10.1097/MD.0000000000034251. PMID: 37478210Free PMC Article
Reciprocal FGF19-GLI2 signaling induces epithelial-to-mesenchymal transition to promote lung squamous cell carcinoma metastasis.
Zhang Y, Wu T, Wang Y, Chen Z, Chen J, Lu S, Xia W
Cell Oncol (Dordr) 2023 Apr;46(2):437-450. Epub 2023 Jan 4 doi: 10.1007/s13402-022-00760-y. PMID: 36598638
Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study.
Liu Y, Sun M, Xiong Y, Gu X, Zhang K, Liu L
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221132035. doi: 10.1177/15330338221132035. PMID: 36217877Free PMC Article
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study.
Zhang J, Pan Y, Shi Q, Zhang G, Jiang L, Dong X, Gu K, Wang H, Zhang X, Yang N, Li Y, Xiong J, Yi T, Peng M, Song Y, Fan Y, Cui J, Chen G, Tan W, Zang A, Guo Q, Zhao G, Wang Z, He J, Yao W, Wu X, Chen K, Hu X, Hu C, Yue L, Jiang D, Wang G, Liu J, Yu G, Li J, Bai J, Xie W, Zhao W, Wu L, Zhou C
Cancer Commun (Lond) 2022 Jan;42(1):3-16. Epub 2021 Oct 26 doi: 10.1002/cac2.12225. PMID: 34699693Free PMC Article
The Current Landscape of Immune Checkpoint Blockade in Metastatic Lung Squamous Cell Carcinoma.
Yuan H, Liu J, Zhang J
Molecules 2021 Mar 5;26(5) doi: 10.3390/molecules26051392. PMID: 33807509Free PMC Article

Clinical prediction guides

Reciprocal FGF19-GLI2 signaling induces epithelial-to-mesenchymal transition to promote lung squamous cell carcinoma metastasis.
Zhang Y, Wu T, Wang Y, Chen Z, Chen J, Lu S, Xia W
Cell Oncol (Dordr) 2023 Apr;46(2):437-450. Epub 2023 Jan 4 doi: 10.1007/s13402-022-00760-y. PMID: 36598638
Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study.
Liu Y, Sun M, Xiong Y, Gu X, Zhang K, Liu L
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221132035. doi: 10.1177/15330338221132035. PMID: 36217877Free PMC Article
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study.
Zhang J, Pan Y, Shi Q, Zhang G, Jiang L, Dong X, Gu K, Wang H, Zhang X, Yang N, Li Y, Xiong J, Yi T, Peng M, Song Y, Fan Y, Cui J, Chen G, Tan W, Zang A, Guo Q, Zhao G, Wang Z, He J, Yao W, Wu X, Chen K, Hu X, Hu C, Yue L, Jiang D, Wang G, Liu J, Yu G, Li J, Bai J, Xie W, Zhao W, Wu L, Zhou C
Cancer Commun (Lond) 2022 Jan;42(1):3-16. Epub 2021 Oct 26 doi: 10.1002/cac2.12225. PMID: 34699693Free PMC Article
The Current Landscape of Immune Checkpoint Blockade in Metastatic Lung Squamous Cell Carcinoma.
Yuan H, Liu J, Zhang J
Molecules 2021 Mar 5;26(5) doi: 10.3390/molecules26051392. PMID: 33807509Free PMC Article
Abscopal effect induced by modulated radiation therapy and pembrolizumab in a patient with pancreatic metastatic lung squamous cell carcinoma.
Wang W, Huang C, Wu S, Liu Z, Liu L, Li L, Li S
Thorac Cancer 2020 Jul;11(7):2014-2017. Epub 2020 May 11 doi: 10.1111/1759-7714.13427. PMID: 32391640Free PMC Article

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