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Type II atherosclerotic lesion

MedGen UID:
1632881
•Concept ID:
C4703475
•
Disease or Syndrome
HPO: HP:0031680

Definition

Type II atherosclerotic lesions include the fatty streak lesion, the first grossly visible lesion, and are characterized by layers of macrophage foam cells and lipid droplets within intimal smooth muscle cells and minimal coarse-grained particles and heterogeneous droplets of extracellular lipid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType II atherosclerotic lesion

Professional guidelines

PubMed

Recent progress in the treatment of cardiovascular disease using olmesartan.
Miura S, Saku K
Clin Exp Hypertens 2014;36(7):441-6. Epub 2013 Oct 28 doi: 10.3109/10641963.2013.846363. PMID: 24164503
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach.
Späh F
Br J Dermatol 2008 Aug;159 Suppl 2:10-7. doi: 10.1111/j.1365-2133.2008.08780.x. PMID: 18700910
Role of risk factor management in progression and regression of coronary and femoral artery atherosclerosis.
Glueck CJ
Am J Cardiol 1986 May 30;57(14):35G-41G. doi: 10.1016/0002-9149(86)90664-8. PMID: 3521250

Recent clinical studies

Etiology

An update on lipid apheresis for familial hypercholesterolemia.
Taylan C, Weber LT
Pediatr Nephrol 2023 Feb;38(2):371-382. Epub 2022 Apr 25 doi: 10.1007/s00467-022-05541-1. PMID: 35467154Free PMC Article
ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future.
Kalayci A, Gibson CM, Ridker PM, Wright SD, Kingwell BA, Korjian S, Chi G, Lee JJ, Tricoci P, Kazmi SH, Fitzgerald C, Shaunik A, Berman G, Duffy D, Libby P
Curr Atheroscler Rep 2022 Jul;24(7):585-597. Epub 2022 May 7 doi: 10.1007/s11883-022-01025-7. PMID: 35524914Free PMC Article
Inhibition of Vascular Calcification.
Liu L, Zeng P, Yang X, Duan Y, Zhang W, Ma C, Zhang X, Yang S, Li X, Yang J, Liang Y, Han H, Zhu Y, Han J, Chen Y
Arterioscler Thromb Vasc Biol 2018 Oct;38(10):2382-2395. doi: 10.1161/ATVBAHA.118.311546. PMID: 30354214
The forgotten face of regular physical exercise: a 'natural' anti-atherogenic activity.
Szostak J, Laurant P
Clin Sci (Lond) 2011 Aug;121(3):91-106. doi: 10.1042/CS20100520. PMID: 21729002
Vascular dermatan sulfate and heparin cofactor II.
Tollefsen DM
Prog Mol Biol Transl Sci 2010;93:351-72. doi: 10.1016/S1877-1173(10)93015-9. PMID: 20807652

Diagnosis

Endovascular Treatment for Critical Limb Ischemia in Type II Diabetes Mellitus Involving Femoropopliteal and Infrapopliteal Segments: Revascularization Strategy.
Al-Zoubi NA, Shatnawi NJ, Bakkar L, Al-Sabah M
Vasc Health Risk Manag 2021;17:69-76. Epub 2021 Mar 4 doi: 10.2147/VHRM.S298435. PMID: 33692625Free PMC Article
Interobserver variability in assessments of atherosclerotic lesion type via optical frequency domain imaging.
Shibutani H, Fujii K, Kawakami R, Imanaka T, Kawai K, Tsujimoto S, Matsumura K, Otagaki M, Morishita S, Hashimoto K, Hao H, Hirota S, Shiojima I
J Cardiol 2021 May;77(5):465-470. Epub 2020 Nov 28 doi: 10.1016/j.jjcc.2020.11.009. PMID: 33257209
Clinical Practice Recommendations for Pediatric Dyslipidemia.
Elkins C, Fruh S, Jones L, Bydalek K
J Pediatr Health Care 2019 Jul-Aug;33(4):494-504. doi: 10.1016/j.pedhc.2019.02.009. PMID: 31227123
Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.
Takai S, Miyazaki M
Am J Cardiovasc Drugs 2006;6(6):363-6. doi: 10.2165/00129784-200606060-00002. PMID: 17192125
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in atherogenesis.
Kume N, Kita T
Trends Cardiovasc Med 2001 Jan;11(1):22-5. doi: 10.1016/s1050-1738(01)00079-2. PMID: 11413048

Therapy

The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy.
Xu H, Fu J, Tu Q, Shuai Q, Chen Y, Wu F, Cao Z
J Physiol Biochem 2024 Feb;80(1):27-39. Epub 2023 Oct 4 doi: 10.1007/s13105-023-00974-0. PMID: 37792168
ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future.
Kalayci A, Gibson CM, Ridker PM, Wright SD, Kingwell BA, Korjian S, Chi G, Lee JJ, Tricoci P, Kazmi SH, Fitzgerald C, Shaunik A, Berman G, Duffy D, Libby P
Curr Atheroscler Rep 2022 Jul;24(7):585-597. Epub 2022 May 7 doi: 10.1007/s11883-022-01025-7. PMID: 35524914Free PMC Article
Intravascular Ultrasound-Assisted Endovascular Exclusion of Penetrating Aortic Ulcers.
Illuminati G, Pasqua R, Nardi P, Fratini C, Calio FG, Ricco JB
Ann Vasc Surg 2021 Jan;70:467-473. Epub 2020 Jul 4 doi: 10.1016/j.avsg.2020.06.059. PMID: 32634558
Recent progress in the treatment of cardiovascular disease using olmesartan.
Miura S, Saku K
Clin Exp Hypertens 2014;36(7):441-6. Epub 2013 Oct 28 doi: 10.3109/10641963.2013.846363. PMID: 24164503
Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.
Takai S, Miyazaki M
Am J Cardiovasc Drugs 2006;6(6):363-6. doi: 10.2165/00129784-200606060-00002. PMID: 17192125

Prognosis

An update on lipid apheresis for familial hypercholesterolemia.
Taylan C, Weber LT
Pediatr Nephrol 2023 Feb;38(2):371-382. Epub 2022 Apr 25 doi: 10.1007/s00467-022-05541-1. PMID: 35467154Free PMC Article
Interobserver variability in assessments of atherosclerotic lesion type via optical frequency domain imaging.
Shibutani H, Fujii K, Kawakami R, Imanaka T, Kawai K, Tsujimoto S, Matsumura K, Otagaki M, Morishita S, Hashimoto K, Hao H, Hirota S, Shiojima I
J Cardiol 2021 May;77(5):465-470. Epub 2020 Nov 28 doi: 10.1016/j.jjcc.2020.11.009. PMID: 33257209
HDL abnormalities in familial hypercholesterolemia: Focus on biological functions.
Ganjali S, Momtazi AA, Banach M, Kovanen PT, Stein EA, Sahebkar A
Prog Lipid Res 2017 Jul;67:16-26. Epub 2017 May 12 doi: 10.1016/j.plipres.2017.05.001. PMID: 28506805
ACE inhibitors and angiotensin II receptor antagonists.
Dendorfer A, Dominiak P, Schunkert H
Handb Exp Pharmacol 2005;(170):407-42. doi: 10.1007/3-540-27661-0_15. PMID: 16596809
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in atherogenesis.
Kume N, Kita T
Trends Cardiovasc Med 2001 Jan;11(1):22-5. doi: 10.1016/s1050-1738(01)00079-2. PMID: 11413048

Clinical prediction guides

Interobserver variability in assessments of atherosclerotic lesion type via optical frequency domain imaging.
Shibutani H, Fujii K, Kawakami R, Imanaka T, Kawai K, Tsujimoto S, Matsumura K, Otagaki M, Morishita S, Hashimoto K, Hao H, Hirota S, Shiojima I
J Cardiol 2021 May;77(5):465-470. Epub 2020 Nov 28 doi: 10.1016/j.jjcc.2020.11.009. PMID: 33257209
Intravascular Ultrasound-Assisted Endovascular Exclusion of Penetrating Aortic Ulcers.
Illuminati G, Pasqua R, Nardi P, Fratini C, Calio FG, Ricco JB
Ann Vasc Surg 2021 Jan;70:467-473. Epub 2020 Jul 4 doi: 10.1016/j.avsg.2020.06.059. PMID: 32634558
Atherosclerosis in cholesterol-fed rabbits and in homozygous and heterozygous LDL receptor-deficient humans.
Thompson GR
Atherosclerosis 2018 Sep;276:148-154. Epub 2018 Jul 26 doi: 10.1016/j.atherosclerosis.2018.07.032. PMID: 30064057
Vascular dermatan sulfate and heparin cofactor II.
Tollefsen DM
Prog Mol Biol Transl Sci 2010;93:351-72. doi: 10.1016/S1877-1173(10)93015-9. PMID: 20807652
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in atherogenesis.
Kume N, Kita T
Trends Cardiovasc Med 2001 Jan;11(1):22-5. doi: 10.1016/s1050-1738(01)00079-2. PMID: 11413048

Supplemental Content

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