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Type III atherosclerotic lesion

MedGen UID:
1634853
•Concept ID:
C4703476
•
Disease or Syndrome
HPO: HP:0031681

Definition

Type III (intermediate) atherosclerotic lesions are the morphological and chemical bridge between type II and advanced lesions. Type III lesions appear in some adaptive intimal thickenings (progression-prone locations) in young adults and are characterized by pools of extracellular lipid in addition to all the components of type II lesions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType III atherosclerotic lesion

Professional guidelines

PubMed

Is the Endovascular Treatment of Mild Iliac Stenoses Worthwhile to Improve Wound Healing in Patients Undergoing Femorotibial Bypass?
Sapienza P, Venturini L, Grande R, Scarano Catanzaro V, Gazzanelli S, Sterpetti AV, Tartaglia E
Ann Vasc Surg 2018 Feb;47:162-169. Epub 2017 Sep 8 doi: 10.1016/j.avsg.2017.08.023. PMID: 28890068

Recent clinical studies

Etiology

Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases.
Benincasa G, Suades R, Padró T, Badimon L, Napoli C
Eur Heart J Cardiovasc Pharmacother 2023 Dec 14;9(8):758-769. doi: 10.1093/ehjcvp/pvad059. PMID: 37562936
ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future.
Kalayci A, Gibson CM, Ridker PM, Wright SD, Kingwell BA, Korjian S, Chi G, Lee JJ, Tricoci P, Kazmi SH, Fitzgerald C, Shaunik A, Berman G, Duffy D, Libby P
Curr Atheroscler Rep 2022 Jul;24(7):585-597. Epub 2022 May 7 doi: 10.1007/s11883-022-01025-7. PMID: 35524914Free PMC Article
ApoB in clinical care: Pro and Con.
Sniderman AD, Robinson JG
Atherosclerosis 2019 Mar;282:169-175. Epub 2018 Nov 10 doi: 10.1016/j.atherosclerosis.2018.11.001. PMID: 30463677
Regenerative medicine in critical limb ischemia.
Ohno T, Kaneda H, Nagai Y, Fukushima M
J Atheroscler Thromb 2012;19(10):883-9. Epub 2012 Jun 8 doi: 10.5551/jat.12906. PMID: 22785564
Oxidative stress and endothelial dysfunction in hypertension.
Schulz E, Gori T, Münzel T
Hypertens Res 2011 Jun;34(6):665-73. Epub 2011 Apr 21 doi: 10.1038/hr.2011.39. PMID: 21512515

Diagnosis

Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases.
Benincasa G, Suades R, Padró T, Badimon L, Napoli C
Eur Heart J Cardiovasc Pharmacother 2023 Dec 14;9(8):758-769. doi: 10.1093/ehjcvp/pvad059. PMID: 37562936
ApoB in clinical care: Pro and Con.
Sniderman AD, Robinson JG
Atherosclerosis 2019 Mar;282:169-175. Epub 2018 Nov 10 doi: 10.1016/j.atherosclerosis.2018.11.001. PMID: 30463677
Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery.
Yu M, Ortega CA, Si K, Molinaro R, Schoen FJ, Leitao RFC, Xu X, Mahmoudi M, Ahn S, Liu J, Saw PE, Lee IH, Brayner MMB, Lotfi A, Shi J, Libby P, Jon S, Farokhzad OC
Theranostics 2018;8(21):6008-6024. Epub 2018 Nov 15 doi: 10.7150/thno.24365. PMID: 30613278Free PMC Article
C-reactive protein and atherothrombosis: Cause or effect?
Grad E, Danenberg HD
Blood Rev 2013 Jan;27(1):23-9. Epub 2012 Dec 23 doi: 10.1016/j.blre.2012.12.001. PMID: 23266251
Tesaglitazar: a promising approach in type 2 diabetes.
Cox SL
Drugs Today (Barc) 2006 Mar;42(3):139-46. doi: 10.1358/dot.2006.42.3.937961. PMID: 16628256

Therapy

Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases.
Benincasa G, Suades R, Padró T, Badimon L, Napoli C
Eur Heart J Cardiovasc Pharmacother 2023 Dec 14;9(8):758-769. doi: 10.1093/ehjcvp/pvad059. PMID: 37562936
ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future.
Kalayci A, Gibson CM, Ridker PM, Wright SD, Kingwell BA, Korjian S, Chi G, Lee JJ, Tricoci P, Kazmi SH, Fitzgerald C, Shaunik A, Berman G, Duffy D, Libby P
Curr Atheroscler Rep 2022 Jul;24(7):585-597. Epub 2022 May 7 doi: 10.1007/s11883-022-01025-7. PMID: 35524914Free PMC Article
Regenerative medicine in critical limb ischemia.
Ohno T, Kaneda H, Nagai Y, Fukushima M
J Atheroscler Thromb 2012;19(10):883-9. Epub 2012 Jun 8 doi: 10.5551/jat.12906. PMID: 22785564
The role of endoglin in atherosclerosis.
Nachtigal P, Zemankova Vecerova L, Rathouska J, Strasky Z
Atherosclerosis 2012 Sep;224(1):4-11. Epub 2012 Mar 9 doi: 10.1016/j.atherosclerosis.2012.03.001. PMID: 22460049
Vascular effects of dietary L-arginine supplementation.
Preli RB, Klein KP, Herrington DM
Atherosclerosis 2002 May;162(1):1-15. doi: 10.1016/s0021-9150(01)00717-1. PMID: 11947892

Prognosis

Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases.
Benincasa G, Suades R, Padró T, Badimon L, Napoli C
Eur Heart J Cardiovasc Pharmacother 2023 Dec 14;9(8):758-769. doi: 10.1093/ehjcvp/pvad059. PMID: 37562936
Relationship between calcification, atherosclerosis and matrix proteins in the human aorta.
Kuzan A, Wisniewski J, Maksymowicz K, Kobielarz M, Gamian A, Chwilkowska A
Folia Histochem Cytobiol 2021;59(1):8-21. Epub 2021 Feb 9 doi: 10.5603/FHC.a2021.0002. PMID: 33560515
C-reactive protein and atherothrombosis: Cause or effect?
Grad E, Danenberg HD
Blood Rev 2013 Jan;27(1):23-9. Epub 2012 Dec 23 doi: 10.1016/j.blre.2012.12.001. PMID: 23266251
Regenerative medicine in critical limb ischemia.
Ohno T, Kaneda H, Nagai Y, Fukushima M
J Atheroscler Thromb 2012;19(10):883-9. Epub 2012 Jun 8 doi: 10.5551/jat.12906. PMID: 22785564
Oxidative stress and endothelial dysfunction in hypertension.
Schulz E, Gori T, Münzel T
Hypertens Res 2011 Jun;34(6):665-73. Epub 2011 Apr 21 doi: 10.1038/hr.2011.39. PMID: 21512515

Clinical prediction guides

Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases.
Benincasa G, Suades R, Padró T, Badimon L, Napoli C
Eur Heart J Cardiovasc Pharmacother 2023 Dec 14;9(8):758-769. doi: 10.1093/ehjcvp/pvad059. PMID: 37562936
Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models.
Wu Y, Johnson G, Zhao F, Wu Y, Zhao G, Brown A, You S, Zou MH, Song P
Int J Mol Sci 2021 Jul 31;22(15) doi: 10.3390/ijms22158262. PMID: 34361033Free PMC Article
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
Singla B, Lin HP, Chen A, Ahn W, Ghoshal P, Cherian-Shaw M, White J, Stansfield BK, Csányi G
Cardiovasc Res 2021 May 25;117(6):1489-1509. doi: 10.1093/cvr/cvaa244. PMID: 32750106Free PMC Article
Oxidative stress and endothelial dysfunction in hypertension.
Schulz E, Gori T, Münzel T
Hypertens Res 2011 Jun;34(6):665-73. Epub 2011 Apr 21 doi: 10.1038/hr.2011.39. PMID: 21512515
Tesaglitazar: a promising approach in type 2 diabetes.
Cox SL
Drugs Today (Barc) 2006 Mar;42(3):139-46. doi: 10.1358/dot.2006.42.3.937961. PMID: 16628256

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