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BRCA-Associated Ovarian Carcinoma

MedGen UID:
1635506
•Concept ID:
C4688331
•
Neoplastic Process
Synonym: BRCA-Mutated Ovarian Carcinoma

Definition

Ovarian carcinoma caused by deleterious germline mutation in a gene of the BRCA family. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBRCA-Associated Ovarian Carcinoma

Professional guidelines

PubMed

Olaparib in the treatment of ovarian cancer.
Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Veliparib for the treatment of ovarian cancer.
Bogliolo S, Cassani C, Dominoni M, Musacchi V, Venturini PL, Spinillo A, Ferrero S, Gardella B
Expert Opin Investig Drugs 2016;25(3):367-74. Epub 2016 Feb 16 doi: 10.1517/13543784.2016.1146677. PMID: 26807493

Recent clinical studies

Etiology

Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Genetic predisposition in gynecologic cancers.
Daniels MS, Lu KH
Semin Oncol 2016 Oct;43(5):543-547. Epub 2016 Sep 20 doi: 10.1053/j.seminoncol.2016.08.005. PMID: 27899185
Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers.
Shaw PA, Clarke BA
Surg Pathol Clin 2016 Jun;9(2):307-28. doi: 10.1016/j.path.2016.02.002. PMID: 27241111
BRCA1 and BRCA2 mutations and breast cancer.
Narod SA, Salmena L
Discov Med 2011 Nov;12(66):445-53. PMID: 22127115

Diagnosis

Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Olaparib in the treatment of ovarian cancer.
Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Genetic predisposition in gynecologic cancers.
Daniels MS, Lu KH
Semin Oncol 2016 Oct;43(5):543-547. Epub 2016 Sep 20 doi: 10.1053/j.seminoncol.2016.08.005. PMID: 27899185
Olaparib.
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2016 Jan;81(1):171-3. Epub 2015 Oct 24 doi: 10.1111/bcp.12761. PMID: 26344419Free PMC Article

Therapy

A review on mechanisms of resistance to PARP inhibitors.
Desai C, Pathak A, Limaye S, Maniar V, Joshi A
Indian J Cancer 2022 Mar;59(Supplement):S119-S129. doi: 10.4103/ijc.IJC_53_21. PMID: 35343196
PARP inhibition as frontline therapy in ovarian cancer.
Moore KN, Pothuri B, Monk B, Coleman RL
Clin Adv Hematol Oncol 2020 Sep;18(9):550-556. PMID: 33006584
Olaparib in the treatment of ovarian cancer.
Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
Olaparib.
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2016 Jan;81(1):171-3. Epub 2015 Oct 24 doi: 10.1111/bcp.12761. PMID: 26344419Free PMC Article
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS
N Engl J Med 2009 Jul 9;361(2):123-34. Epub 2009 Jun 24 doi: 10.1056/NEJMoa0900212. PMID: 19553641

Prognosis

Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland.
Pallonen TA, Lempiäinen SMM, Joutsiniemi TK, Aaltonen RI, Pohjola PE, Kankuri-Tammilehto MK
Sci Rep 2022 Apr 25;12(1):6704. doi: 10.1038/s41598-022-10519-y. PMID: 35469032Free PMC Article
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
The correlation between BRCA status and surgical cytoreduction in high-grade serous ovarian carcinoma.
Kim SR, Malcolmson J, Li X, Bernardini MQ, Hogen L, May T
Gynecol Oncol 2021 Sep;162(3):702-706. Epub 2021 Jul 10 doi: 10.1016/j.ygyno.2021.07.010. PMID: 34256977
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
BRCA-associated ovarian cancer: from molecular genetics to risk management.
Girolimetti G, Perrone AM, Santini D, Barbieri E, Guerra F, Ferrari S, Zamagni C, De Iaco P, Gasparre G, Turchetti D
Biomed Res Int 2014;2014:787143. Epub 2014 Jul 22 doi: 10.1155/2014/787143. PMID: 25136623Free PMC Article

Clinical prediction guides

Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland.
Pallonen TA, Lempiäinen SMM, Joutsiniemi TK, Aaltonen RI, Pohjola PE, Kankuri-Tammilehto MK
Sci Rep 2022 Apr 25;12(1):6704. doi: 10.1038/s41598-022-10519-y. PMID: 35469032Free PMC Article
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Clinical outcomes and Oncotype DX Breast Recurrence Score® in early-stage BRCA-associated hormone receptor-positive breast cancer.
Layman RM, Lin H, Gutierrez Barrera AM, Karuturi MS, Yam C, Arun BK
Cancer Med 2022 Mar;11(6):1474-1483. Epub 2022 Feb 6 doi: 10.1002/cam4.4566. PMID: 35128817Free PMC Article
The correlation between BRCA status and surgical cytoreduction in high-grade serous ovarian carcinoma.
Kim SR, Malcolmson J, Li X, Bernardini MQ, Hogen L, May T
Gynecol Oncol 2021 Sep;162(3):702-706. Epub 2021 Jul 10 doi: 10.1016/j.ygyno.2021.07.010. PMID: 34256977
BRCA-associated ovarian cancer: from molecular genetics to risk management.
Girolimetti G, Perrone AM, Santini D, Barbieri E, Guerra F, Ferrari S, Zamagni C, De Iaco P, Gasparre G, Turchetti D
Biomed Res Int 2014;2014:787143. Epub 2014 Jul 22 doi: 10.1155/2014/787143. PMID: 25136623Free PMC Article

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