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Anterior chamber flare grade 2+

MedGen UID:
1635954
•Concept ID:
C4703444
•
Finding
HPO: HP:0031619

Definition

Moderate anterior chamber flare (iris and lens details clear). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior chamber flare grade 2+

Professional guidelines

PubMed

Pars Plana Vitrectomy for the Treatment of Uveitis.
Henry CR, Becker MD, Yang Y, Davis JL
Am J Ophthalmol 2018 Jun;190:142-149. Epub 2018 Mar 28 doi: 10.1016/j.ajo.2018.03.031. PMID: 29601822
Mycophenolate mofetil monotherapy in the management of paediatric uveitis.
Chang PY, Giuliari GP, Shaikh M, Thakuria P, Makhoul D, Foster CS
Eye (Lond) 2011 Apr;25(4):427-35. Epub 2011 Mar 18 doi: 10.1038/eye.2011.23. PMID: 21423146Free PMC Article
Infliximab and etanercept in the treatment of chronic uveitis associated with refractory juvenile idiopathic arthritis.
Tynjälä P, Lindahl P, Honkanen V, Lahdenne P, Kotaniemi K
Ann Rheum Dis 2007 Apr;66(4):548-50. Epub 2006 Oct 26 doi: 10.1136/ard.2006.058248. PMID: 17068061Free PMC Article

Recent clinical studies

Etiology

Incidence and Risk Factors of Recurrent Anterior Uveitis in Initial Acute-Onset Vogt-Koyanagi-Harada Disease.
Lim YJ, Byon I, Kim HW, Park SW, Kwon HJ, Kim E
Korean J Ophthalmol 2023 Aug;37(4):299-306. Epub 2023 Jul 3 doi: 10.3341/kjo.2023.0017. PMID: 37400085Free PMC Article
Effect of light backscattering from anterior segment structures on automated flare meter measurements.
Hasanreisoglu M, Kesim C, Yalinbas D, Yilmaz M, Uzunay NS, Aktas Z, Halim MS, Sepah YJ, Nguyen QD, Sahin A
Eur J Ophthalmol 2022 Jul;32(4):2291-2297. Epub 2021 Aug 12 doi: 10.1177/11206721211039350. PMID: 34382443Free PMC Article
Switch from BAK-preserved to preservative-free latanoprost decreases anterior chamber flare in POAG patients.
Kestelyn PA, Kestelyn PG, De Bacquer D, Stevens AM
Int Ophthalmol 2019 Jan;39(1):105-109. Epub 2017 Dec 22 doi: 10.1007/s10792-017-0792-z. PMID: 29274019
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial.
Nguyen QD, Merrill PT, Jaffe GJ, Dick AD, Kurup SK, Sheppard J, Schlaen A, Pavesio C, Cimino L, Van Calster J, Camez AA, Kwatra NV, Song AP, Kron M, Tari S, Brézin AP
Lancet 2016 Sep 17;388(10050):1183-92. Epub 2016 Aug 16 doi: 10.1016/S0140-6736(16)31339-3. PMID: 27542302

Diagnosis

Anterior chamber flare and choroidal vascular index as inflammatory markers after uncomplicated phacoemulsification surgery.
Yalçınkaya Çakır G, Altan Ç, Çakır İ
Int Ophthalmol 2024 Feb 8;44(1):35. doi: 10.1007/s10792-024-02959-4. PMID: 38332452
Anterior chamber inflammation grading methods: A critical review.
Oo HH, Mohan M, Song W, Rojas-Carabali W, Tsui E, de-la-Torre A, Cifuentes-González C, Rousselot A, Srinivas SP, Aslam T, Gupta V, Agrawal R
Surv Ophthalmol 2024 Mar-Apr;69(2):253-264. Epub 2023 Oct 5 doi: 10.1016/j.survophthal.2023.10.005. PMID: 37804869
Incidence and Risk Factors of Recurrent Anterior Uveitis in Initial Acute-Onset Vogt-Koyanagi-Harada Disease.
Lim YJ, Byon I, Kim HW, Park SW, Kwon HJ, Kim E
Korean J Ophthalmol 2023 Aug;37(4):299-306. Epub 2023 Jul 3 doi: 10.3341/kjo.2023.0017. PMID: 37400085Free PMC Article
Effect of light backscattering from anterior segment structures on automated flare meter measurements.
Hasanreisoglu M, Kesim C, Yalinbas D, Yilmaz M, Uzunay NS, Aktas Z, Halim MS, Sepah YJ, Nguyen QD, Sahin A
Eur J Ophthalmol 2022 Jul;32(4):2291-2297. Epub 2021 Aug 12 doi: 10.1177/11206721211039350. PMID: 34382443Free PMC Article
Discrepancies in assessing anterior chamber activity among uveitis specialists.
Yeo TH, Ilangovan S, Keane PA, Pavesio C, Agrawal R
Jpn J Ophthalmol 2016 May;60(3):206-11. Epub 2016 Mar 28 doi: 10.1007/s10384-016-0438-0. PMID: 27020454

Therapy

Anterior chamber flare and choroidal vascular index as inflammatory markers after uncomplicated phacoemulsification surgery.
Yalçınkaya Çakır G, Altan Ç, Çakır İ
Int Ophthalmol 2024 Feb 8;44(1):35. doi: 10.1007/s10792-024-02959-4. PMID: 38332452
Efficacy and safety of adalimumab for inflammatory flare prevention in paediatric non-infectious anterior uveitis with peripheral retinal vascular leakage: a study protocol for a single-centre, randomised controlled trial.
Song H, Zhao C, Zhang Y, Li D, Qian Y, Gao F, Xiao J, Zhang M
BMJ Open 2022 Dec 7;12(12):e062211. doi: 10.1136/bmjopen-2022-062211. PMID: 36600374Free PMC Article
Switch from BAK-preserved to preservative-free latanoprost decreases anterior chamber flare in POAG patients.
Kestelyn PA, Kestelyn PG, De Bacquer D, Stevens AM
Int Ophthalmol 2019 Jan;39(1):105-109. Epub 2017 Dec 22 doi: 10.1007/s10792-017-0792-z. PMID: 29274019
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial.
Nguyen QD, Merrill PT, Jaffe GJ, Dick AD, Kurup SK, Sheppard J, Schlaen A, Pavesio C, Cimino L, Van Calster J, Camez AA, Kwatra NV, Song AP, Kron M, Tari S, Brézin AP
Lancet 2016 Sep 17;388(10050):1183-92. Epub 2016 Aug 16 doi: 10.1016/S0140-6736(16)31339-3. PMID: 27542302

Prognosis

Incidence and Risk Factors of Recurrent Anterior Uveitis in Initial Acute-Onset Vogt-Koyanagi-Harada Disease.
Lim YJ, Byon I, Kim HW, Park SW, Kwon HJ, Kim E
Korean J Ophthalmol 2023 Aug;37(4):299-306. Epub 2023 Jul 3 doi: 10.3341/kjo.2023.0017. PMID: 37400085Free PMC Article
Efficacy and safety of adalimumab for inflammatory flare prevention in paediatric non-infectious anterior uveitis with peripheral retinal vascular leakage: a study protocol for a single-centre, randomised controlled trial.
Song H, Zhao C, Zhang Y, Li D, Qian Y, Gao F, Xiao J, Zhang M
BMJ Open 2022 Dec 7;12(12):e062211. doi: 10.1136/bmjopen-2022-062211. PMID: 36600374Free PMC Article
Comparative evaluation of femtosecond laser-assisted cataract surgery and conventional phacoemulsification in eyes with a shallow anterior chamber.
Vasavada VA, Vasavada S, Vasavada AR, Vasavada V, Srivastava S
J Cataract Refract Surg 2019 May;45(5):547-552. doi: 10.1016/j.jcrs.2018.11.037. PMID: 31030773
Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial.
Bouquet C, Vignal Clermont C, Galy A, Fitoussi S, Blouin L, Munk MR, Valero S, Meunier S, Katz B, Sahel JA, Thomasson N
JAMA Ophthalmol 2019 Apr 1;137(4):399-406. doi: 10.1001/jamaophthalmol.2018.6902. PMID: 30730541Free PMC Article
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665

Clinical prediction guides

Efficacy and safety of adalimumab for inflammatory flare prevention in paediatric non-infectious anterior uveitis with peripheral retinal vascular leakage: a study protocol for a single-centre, randomised controlled trial.
Song H, Zhao C, Zhang Y, Li D, Qian Y, Gao F, Xiao J, Zhang M
BMJ Open 2022 Dec 7;12(12):e062211. doi: 10.1136/bmjopen-2022-062211. PMID: 36600374Free PMC Article
Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial.
Bouquet C, Vignal Clermont C, Galy A, Fitoussi S, Blouin L, Munk MR, Valero S, Meunier S, Katz B, Sahel JA, Thomasson N
JAMA Ophthalmol 2019 Apr 1;137(4):399-406. doi: 10.1001/jamaophthalmol.2018.6902. PMID: 30730541Free PMC Article
Switch from BAK-preserved to preservative-free latanoprost decreases anterior chamber flare in POAG patients.
Kestelyn PA, Kestelyn PG, De Bacquer D, Stevens AM
Int Ophthalmol 2019 Jan;39(1):105-109. Epub 2017 Dec 22 doi: 10.1007/s10792-017-0792-z. PMID: 29274019
Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial.
Nguyen QD, Merrill PT, Jaffe GJ, Dick AD, Kurup SK, Sheppard J, Schlaen A, Pavesio C, Cimino L, Van Calster J, Camez AA, Kwatra NV, Song AP, Kron M, Tari S, Brézin AP
Lancet 2016 Sep 17;388(10050):1183-92. Epub 2016 Aug 16 doi: 10.1016/S0140-6736(16)31339-3. PMID: 27542302
Comparative Analysis of Anterior Chamber Flare Grading between Clinicians with Different Levels of Experience and Semi-automated Laser Flare Photometry.
Agrawal R, Keane PA, Singh J, Saihan Z, Kontos A, Pavesio CE
Ocul Immunol Inflamm 2016;24(2):184-93. Epub 2014 Dec 26 doi: 10.3109/09273948.2014.990042. PMID: 25541860

Recent systematic reviews

The Efficacy and Safety of Standard versus Soft Topical Steroids after Cataract Surgery: A Systematic Review and Meta-analysis.
Noyman DBE, Chan CC, Mimouni M, Safir M
Ophthalmology 2024 May;131(5):595-610. Epub 2023 Nov 23 doi: 10.1016/j.ophtha.2023.11.022. PMID: 38007198
Difluprednate versus Prednisolone Acetate after Cataract Surgery: a Systematic Review and Meta-Analysis.
KhalafAllah MT, Basiony A, Salama A
BMJ Open 2019 Nov 2;9(11):e026752. doi: 10.1136/bmjopen-2018-026752. PMID: 31678934Free PMC Article
Pars Plana Vitrectomy for the Treatment of Uveitis.
Henry CR, Becker MD, Yang Y, Davis JL
Am J Ophthalmol 2018 Jun;190:142-149. Epub 2018 Mar 28 doi: 10.1016/j.ajo.2018.03.031. PMID: 29601822
Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery.
Juthani VV, Clearfield E, Chuck RS
Cochrane Database Syst Rev 2017 Jul 3;7(7):CD010516. doi: 10.1002/14651858.CD010516.pub2. PMID: 28670710Free PMC Article

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