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Small Lymphocytic Lymphoma

MedGen UID:
163602
Concept ID:
C0855095
Neoplastic Process
Synonyms: B-Cell Small Lymphocytic Lymphoma; Lymphocytic lymphoma; Lymphocytic lymphosarcoma; Malignant lymphoma - small cell; Malignant lymphoma - small lymphocytic; Malignant lymphoma, lymphocytic, diffuse; Malignant lymphoma, lymphocytic, well differentiated; Malignant lymphoma, lymphocytic, well differentiated, diffuse; Malignant lymphoma, small B lymphocytic; Malignant lymphoma, small cell; Malignant lymphoma, small cell diffuse; Malignant lymphoma, small lymphocytic; Malignant lymphoma, small lymphocytic, diffuse; Small B-Cell Lymphocytic Lymphoma; Small lymphocytic lymphoma
SNOMED CT: Malignant lymphoma, small lymphocytic (64575004); Malignant lymphoma, lymphocytic, diffuse (64575004); Malignant lymphoma, small cell (64575004); Malignant lymphoma, lymphocytic, well differentiated, diffuse (64575004); Malignant lymphoma, small lymphocytic, diffuse (64575004); Malignant lymphoma, small cell diffuse (64575004); Malignant lymphoma, small B lymphocytic (64575004); Small lymphocytic lymphoma (302841002); Malignant lymphoma, lymphocytic, well differentiated (302841002); Lymphocytic lymphoma (302841002); Lymphocytic lymphosarcoma (302841002); Malignant lymphoma - small cell (302841002); Malignant lymphoma - small lymphocytic (302841002)

Definition

A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in the lymph nodes. When the lymphoid process predominantly involves the bone marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, 2001) [from NCI]

Professional guidelines

PubMed

Yoshino T, Tanaka T, Sato Y
J Clin Exp Hematop 2020 Dec 15;60(4):124-129. Epub 2020 Apr 3 doi: 10.3960/jslrt.19041. PMID: 32249238Free PMC Article
Barrientos JC
Future Oncol 2016 Sep;12(18):2077-94. Epub 2016 Jun 21 doi: 10.2217/fon-2016-0003. PMID: 27324214
Graf SA, Gopal AK
Expert Opin Pharmacother 2016;17(2):265-74. Epub 2016 Jan 28 doi: 10.1517/14656566.2016.1135130. PMID: 26818003Free PMC Article

Recent clinical studies

Etiology

Tam CS, Brown JR, Kahl BS, Ghia P, Giannopoulos K, Jurczak W, Šimkovič M, Shadman M, Österborg A, Laurenti L, Walker P, Opat S, Chan H, Ciepluch H, Greil R, Tani M, Trněný M, Brander DM, Flinn IW, Grosicki S, Verner E, Tedeschi A, Li J, Tian T, Zhou L, Marimpietri C, Paik JC, Cohen A, Huang J, Robak T, Hillmen P
Lancet Oncol 2022 Aug;23(8):1031-1043. Epub 2022 Jul 7 doi: 10.1016/S1470-2045(22)00293-5. PMID: 35810754
Moreno C, Greil R, Demirkan F, Tedeschi A, Anz B, Larratt L, Simkovic M, Novak J, Strugov V, Gill D, Gribben JG, Kwei K, Dai S, Hsu E, Dean JP, Flinn IW
Haematologica 2022 Sep 1;107(9):2108-2120. doi: 10.3324/haematol.2021.279012. PMID: 35021599Free PMC Article
Munir T, Brown JR, O'Brien S, Barrientos JC, Barr PM, Reddy NM, Coutre S, Tam CS, Mulligan SP, Jaeger U, Kipps TJ, Moreno C, Montillo M, Burger JA, Byrd JC, Hillmen P, Dai S, Szoke A, Dean JP, Woyach JA
Am J Hematol 2019 Dec;94(12):1353-1363. Epub 2019 Oct 13 doi: 10.1002/ajh.25638. PMID: 31512258Free PMC Article
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Burger JA, Tedeschi A, Barr PM, Robak T, Owen C, Ghia P, Bairey O, Hillmen P, Bartlett NL, Li J, Simpson D, Grosicki S, Devereux S, McCarthy H, Coutre S, Quach H, Gaidano G, Maslyak Z, Stevens DA, Janssens A, Offner F, Mayer J, O'Dwyer M, Hellmann A, Schuh A, Siddiqi T, Polliack A, Tam CS, Suri D, Cheng M, Clow F, Styles L, James DF, Kipps TJ; RESONATE-2 Investigators
N Engl J Med 2015 Dec 17;373(25):2425-37. Epub 2015 Dec 6 doi: 10.1056/NEJMoa1509388. PMID: 26639149Free PMC Article

Diagnosis

Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Yoshino T, Tanaka T, Sato Y
J Clin Exp Hematop 2020 Dec 15;60(4):124-129. Epub 2020 Apr 3 doi: 10.3960/jslrt.19041. PMID: 32249238Free PMC Article
Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882
Leslie LA, Skarbnik AP, Bejot C, Stives S, Feldman TA, Goy AH
Expert Rev Hematol 2017 Apr;10(4):299-313. Epub 2017 Mar 15 doi: 10.1080/17474086.2017.1303374. PMID: 28277849
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174

Therapy

Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Tam CS, Brown JR, Kahl BS, Ghia P, Giannopoulos K, Jurczak W, Šimkovič M, Shadman M, Österborg A, Laurenti L, Walker P, Opat S, Chan H, Ciepluch H, Greil R, Tani M, Trněný M, Brander DM, Flinn IW, Grosicki S, Verner E, Tedeschi A, Li J, Tian T, Zhou L, Marimpietri C, Paik JC, Cohen A, Huang J, Robak T, Hillmen P
Lancet Oncol 2022 Aug;23(8):1031-1043. Epub 2022 Jul 7 doi: 10.1016/S1470-2045(22)00293-5. PMID: 35810754
Mato AR, Shah NN, Jurczak W, Cheah CY, Pagel JM, Woyach JA, Fakhri B, Eyre TA, Lamanna N, Patel MR, Alencar A, Lech-Maranda E, Wierda WG, Coombs CC, Gerson JN, Ghia P, Le Gouill S, Lewis DJ, Sundaram S, Cohen JB, Flinn IW, Tam CS, Barve MA, Kuss B, Taylor J, Abdel-Wahab O, Schuster SJ, Palomba ML, Lewis KL, Roeker LE, Davids MS, Tan XN, Fenske TS, Wallin J, Tsai DE, Ku NC, Zhu E, Chen J, Yin M, Nair B, Ebata K, Marella N, Brown JR, Wang M
Lancet 2021 Mar 6;397(10277):892-901. doi: 10.1016/S0140-6736(21)00224-5. PMID: 33676628
Burger JA
Cancer J 2019 Nov/Dec;25(6):386-393. doi: 10.1097/PPO.0000000000000412. PMID: 31764119Free PMC Article
Munir T, Brown JR, O'Brien S, Barrientos JC, Barr PM, Reddy NM, Coutre S, Tam CS, Mulligan SP, Jaeger U, Kipps TJ, Moreno C, Montillo M, Burger JA, Byrd JC, Hillmen P, Dai S, Szoke A, Dean JP, Woyach JA
Am J Hematol 2019 Dec;94(12):1353-1363. Epub 2019 Oct 13 doi: 10.1002/ajh.25638. PMID: 31512258Free PMC Article

Prognosis

Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Condoluci A, Rossi D
Curr Oncol Rep 2021 Feb 12;23(3):26. doi: 10.1007/s11912-020-01001-x. PMID: 33580422Free PMC Article
Munir T, Brown JR, O'Brien S, Barrientos JC, Barr PM, Reddy NM, Coutre S, Tam CS, Mulligan SP, Jaeger U, Kipps TJ, Moreno C, Montillo M, Burger JA, Byrd JC, Hillmen P, Dai S, Szoke A, Dean JP, Woyach JA
Am J Hematol 2019 Dec;94(12):1353-1363. Epub 2019 Oct 13 doi: 10.1002/ajh.25638. PMID: 31512258Free PMC Article
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174

Clinical prediction guides

Tam CS, Brown JR, Kahl BS, Ghia P, Giannopoulos K, Jurczak W, Šimkovič M, Shadman M, Österborg A, Laurenti L, Walker P, Opat S, Chan H, Ciepluch H, Greil R, Tani M, Trněný M, Brander DM, Flinn IW, Grosicki S, Verner E, Tedeschi A, Li J, Tian T, Zhou L, Marimpietri C, Paik JC, Cohen A, Huang J, Robak T, Hillmen P
Lancet Oncol 2022 Aug;23(8):1031-1043. Epub 2022 Jul 7 doi: 10.1016/S1470-2045(22)00293-5. PMID: 35810754
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Mato AR, Shah NN, Jurczak W, Cheah CY, Pagel JM, Woyach JA, Fakhri B, Eyre TA, Lamanna N, Patel MR, Alencar A, Lech-Maranda E, Wierda WG, Coombs CC, Gerson JN, Ghia P, Le Gouill S, Lewis DJ, Sundaram S, Cohen JB, Flinn IW, Tam CS, Barve MA, Kuss B, Taylor J, Abdel-Wahab O, Schuster SJ, Palomba ML, Lewis KL, Roeker LE, Davids MS, Tan XN, Fenske TS, Wallin J, Tsai DE, Ku NC, Zhu E, Chen J, Yin M, Nair B, Ebata K, Marella N, Brown JR, Wang M
Lancet 2021 Mar 6;397(10277):892-901. doi: 10.1016/S0140-6736(21)00224-5. PMID: 33676628
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Byrd JC, Brown JR, O'Brien S, Barrientos JC, Kay NE, Reddy NM, Coutre S, Tam CS, Mulligan SP, Jaeger U, Devereux S, Barr PM, Furman RR, Kipps TJ, Cymbalista F, Pocock C, Thornton P, Caligaris-Cappio F, Robak T, Delgado J, Schuster SJ, Montillo M, Schuh A, de Vos S, Gill D, Bloor A, Dearden C, Moreno C, Jones JJ, Chu AD, Fardis M, McGreivy J, Clow F, James DF, Hillmen P; RESONATE Investigators
N Engl J Med 2014 Jul 17;371(3):213-23. Epub 2014 May 31 doi: 10.1056/NEJMoa1400376. PMID: 24881631Free PMC Article

Recent systematic reviews

Banerjee T, Kim MS, Haslam A, Prasad V
JAMA Intern Med 2023 May 1;183(5):435-441. doi: 10.1001/jamainternmed.2023.0190. PMID: 36939665Free PMC Article
Davies GA, Strader C, Chibbar R, Papatheodorou S, Dmytriw AA
BMC Cancer 2020 Oct 6;20(1):962. doi: 10.1186/s12885-020-07431-x. PMID: 33023529Free PMC Article
Hidayat K, Li HJ, Shi BM
Crit Rev Oncol Hematol 2018 Sep;129:113-123. Epub 2018 Jun 6 doi: 10.1016/j.critrevonc.2018.05.018. PMID: 30097229
Chen F, Hu J, Liu P, Li J, Wei Z, Liu P
Ann Hematol 2017 Jun;96(6):957-965. Epub 2016 Dec 24 doi: 10.1007/s00277-016-2898-1. PMID: 28011986
Ye X, Casaclang N, Mahmud SM
Hematol Oncol 2015 Dec;33(4):176-86. Epub 2014 Oct 23 doi: 10.1002/hon.2165. PMID: 25345915

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