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Lung Myoepithelial Tumor

MedGen UID:
1636836
•Concept ID:
C4688652
•
Neoplastic Process

Definition

A very rare, benign or malignant lung tumor with myoepithelial differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Myoepithelial Tumor

Professional guidelines

PubMed

Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Clinical outcomes and the role of bronchoscopic intervention in patients with primary pulmonary salivary gland-type tumors.
Kim BG, Lee K, Um SW, Han J, Cho JH, Kim J, Kim H, Jeong BH
Lung Cancer 2020 Aug;146:58-65. Epub 2020 May 22 doi: 10.1016/j.lungcan.2020.05.016. PMID: 32512274
Basal phenotype breast cancer: implications for treatment and prognosis.
Pazaiti A, Fentiman IS
Womens Health (Lond) 2011 Mar;7(2):181-202. doi: 10.2217/whe.11.5. PMID: 21410345

Recent clinical studies

Etiology

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Pulmonary Myoepithelial Tumors With Exuberant Reactive Pneumocytes: Proposed Reclassification of So-called Pneumocytic Adenomyoepithelioma.
Yuan L, Katabi N, Antonescu CR, Golden A, Travis WD, Rekhtman N
Am J Surg Pathol 2020 Jan;44(1):140-147. doi: 10.1097/PAS.0000000000001376. PMID: 31567188Free PMC Article
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Primary Pulmonary Salivary Gland-type Tumors: A Review and Update.
Falk N, Weissferdt A, Kalhor N, Moran CA
Adv Anat Pathol 2016 Jan;23(1):13-23. doi: 10.1097/PAP.0000000000000099. PMID: 26645458
Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status.
Thway K, Fisher C
Am J Surg Pathol 2012 Jul;36(7):e1-e11. doi: 10.1097/PAS.0b013e31825485c5. PMID: 22510762

Diagnosis

Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
SWI/SNF-deficient thoraco-pulmonary neoplasms.
Sesboue C, Le Loarer F
Semin Diagn Pathol 2021 May;38(3):183-194. Epub 2021 Jan 12 doi: 10.1053/j.semdp.2020.12.002. PMID: 33451916
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Myoepithelial carcinoma of the lung: a review.
Rosen LE, Singh RI, Vercillo M, Gattuso P
Appl Immunohistochem Mol Morphol 2015 Jul;23(6):397-401. doi: 10.1097/PAI.0000000000000113. PMID: 25517870
Endotracheal myoepithelioma.
Chand M, Mann JM, Sabayev V, Luo JJ, Cohen PR, Travis WD, Lee PC, Paul S
Chest 2011 Jul;140(1):242-244. doi: 10.1378/chest.10-2976. PMID: 21729896

Therapy

An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion.
Haglund C, Zemmler M, Tsagkozis P, Haglund de Flon F
Genes Chromosomes Cancer 2023 Oct;62(10):607-610. Epub 2023 May 2 doi: 10.1002/gcc.23148. PMID: 37129228
Anti-androgen for myoepithelial tumor: a potent therapy yet a potential misleader.
Hijab A, Taha T, Charas T, Bar-Sela G, Stein P, Agbarya A
Anticancer Drugs 2022 Jan 1;33(1):e747-e751. doi: 10.1097/CAD.0000000000001175. PMID: 34387605
A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion.
Xie X, Lin X, Liu M, Qin Y, Ouyang M, Li S, Gu Y, Chen S, Xiang J, Zhou C
Diagn Pathol 2020 Jun 6;15(1):71. doi: 10.1186/s13000-020-00986-0. PMID: 32505185Free PMC Article
Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice.
Achyut BR, Zhang H, Angara K, Mivechi NF, Arbab AS, Ko L
Cancer Lett 2020 Apr 28;476:57-66. Epub 2020 Feb 12 doi: 10.1016/j.canlet.2020.02.005. PMID: 32061755Free PMC Article
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature.
Kobayashi T, Hiura A, Oishi K, Maeda S, Le Pavoux AJ, Ohara K, Uruga H
Am J Dermatopathol 2016 Dec;38(12):910-914. doi: 10.1097/DAD.0000000000000703. PMID: 27870729Free PMC Article

Prognosis

Recent developments in the pathology of primary pulmonary salivary gland-type tumours.
Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Primary Salivary Gland Type Tumors of the Thymus.
Kalhor N, Weissferdt A, Moran CA
Adv Anat Pathol 2017 Jan;24(1):15-23. doi: 10.1097/PAP.0000000000000132. PMID: 27941539
Primary adenomyoepithelioma of tonsil.
Ren J, Song L, Dang Q, Zhang X, Jiang SW, Zhang G, Wang N, Liu Z, Wang J, Hwa YL, Li Z, Zhao X, Liu Y
Head Neck Oncol 2010 Mar 31;2:7. doi: 10.1186/1758-3284-2-7. PMID: 20356364Free PMC Article

Clinical prediction guides

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Recent updates in salivary gland tumors of the lung.
Roden AC
Semin Diagn Pathol 2021 Sep;38(5):98-108. Epub 2021 Mar 11 doi: 10.1053/j.semdp.2021.03.001. PMID: 33744018
APRIL promotes breast tumor growth and metastasis and is associated with aggressive basal breast cancer.
García-Castro A, Zonca M, Florindo-Pinheiro D, Carvalho-Pinto CE, Cordero A, Gutiérrez del Fernando B, García-Grande A, Mañes S, Hahne M, González-Suárez E, Planelles L
Carcinogenesis 2015 May;36(5):574-84. Epub 2015 Mar 6 doi: 10.1093/carcin/bgv020. PMID: 25750171
Distribution of basal/myoepithelial markers in benign and malignant bronchioloalveolar proliferations of the lung.
Saad RS, Liu YL, Silverman JF
Appl Immunohistochem Mol Morphol 2010 May;18(3):219-25. doi: 10.1097/PAI.0b013e3181c6feec. PMID: 20065853
Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature.
Pelosi G, Fraggetta F, Maffini F, Solli P, Cavallon A, Viale G
Mod Pathol 2001 May;14(5):521-6. doi: 10.1038/modpathol.3880341. PMID: 11353064

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