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Mediastinal Germ Cell Tumor TNM Finding

MedGen UID:
1637179
Concept ID:
C4687483
Finding
Synonym: Thymic Germ Cell Tumor TNM Finding

Definition

A TNM finding about one or more characteristics of a mediastinal germ cell tumor. This is not an official UICC TNM classification. (WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart, 2015) [from NCI]

Recent clinical studies

Etiology

Ruffini E, Huang J, Cilento V, Goren E, Detterbeck F, Ahmad U, Appel S, Bille A, Boubia S, Brambilla C, Cangir AK, Falkson C, Fang W, Filosso PL, Giaccone G, Girard N, Guerrera F, Infante M, Kim DK, Lucchi M, Marino M, Marom EM, Nicholson AG, Okumura M, Rami-Porta R, Rimner A, Simone CB 2nd, Asamura H; Members of the IASLC Staging and Prognostic Factors Committee and of the Advisory Boards, and Participating Institutions
J Thorac Oncol 2023 Dec;18(12):1655-1671. Epub 2023 Sep 9 doi: 10.1016/j.jtho.2023.09.002. PMID: 37689391
Watanabe T, Shimomura H, Mutoh T, Saito R, Goto R, Yamada T, Notsuda H, Matsuda Y, Noda M, Sakurada A, Taki Y, Okada Y
Surg Today 2019 Feb;49(2):143-149. Epub 2018 Sep 10 doi: 10.1007/s00595-018-1712-1. PMID: 30198048
Viti A, Bertolaccini L, Terzi A
Interact Cardiovasc Thorac Surg 2014 Dec;19(6):1054-8. Epub 2014 Sep 4 doi: 10.1093/icvts/ivu281. PMID: 25193970
Fukai I, Masaoka A, Fujii Y, Yamakawa Y, Yokoyama T, Murase T, Eimoto T
Ann Thorac Surg 1999 Jan;67(1):208-11. doi: 10.1016/s0003-4975(98)01063-7. PMID: 10086551
Bajorin DF, Mazumdar M, Meyers M, Motzer RJ, Vlamis V, Lin P, Bosl GJ
J Clin Oncol 1998 Feb;16(2):707-15. doi: 10.1200/JCO.1998.16.2.707. PMID: 9469361

Diagnosis

Watanabe T, Shimomura H, Mutoh T, Saito R, Goto R, Yamada T, Notsuda H, Matsuda Y, Noda M, Sakurada A, Taki Y, Okada Y
Surg Today 2019 Feb;49(2):143-149. Epub 2018 Sep 10 doi: 10.1007/s00595-018-1712-1. PMID: 30198048
Gao S, Li J, Feng X, Shi S, He J
Sci Rep 2016 Apr 1;6:23804. doi: 10.1038/srep23804. PMID: 27033424Free PMC Article
Wang S, Tachimori Y, Hokamura N, Igaki H, Kishino T, Kushima R
Ann Thorac Surg 2013 Sep;96(3):1002-6. Epub 2013 Jun 25 doi: 10.1016/j.athoracsur.2013.04.072. PMID: 23810175
Fukai I, Masaoka A, Fujii Y, Yamakawa Y, Yokoyama T, Murase T, Eimoto T
Ann Thorac Surg 1999 Jan;67(1):208-11. doi: 10.1016/s0003-4975(98)01063-7. PMID: 10086551
Armstrong JD 2nd, Bragg DG
Int J Radiat Oncol Biol Phys 1984 Jan;10(1):109-35. doi: 10.1016/0360-3016(84)90419-x. PMID: 6321408

Therapy

Viti A, Bertolaccini L, Terzi A
Interact Cardiovasc Thorac Surg 2014 Dec;19(6):1054-8. Epub 2014 Sep 4 doi: 10.1093/icvts/ivu281. PMID: 25193970
Nakamura Y, Okada Y, Endo C, Aikawa H, Sakurada A, Sato M, Kondo T
Lung Cancer 2003 Feb;39(2):227-9. doi: 10.1016/s0169-5002(02)00450-6. PMID: 12581578
Bajorin DF, Mazumdar M, Meyers M, Motzer RJ, Vlamis V, Lin P, Bosl GJ
J Clin Oncol 1998 Feb;16(2):707-15. doi: 10.1200/JCO.1998.16.2.707. PMID: 9469361

Prognosis

Ruffini E, Huang J, Cilento V, Goren E, Detterbeck F, Ahmad U, Appel S, Bille A, Boubia S, Brambilla C, Cangir AK, Falkson C, Fang W, Filosso PL, Giaccone G, Girard N, Guerrera F, Infante M, Kim DK, Lucchi M, Marino M, Marom EM, Nicholson AG, Okumura M, Rami-Porta R, Rimner A, Simone CB 2nd, Asamura H; Members of the IASLC Staging and Prognostic Factors Committee and of the Advisory Boards, and Participating Institutions
J Thorac Oncol 2023 Dec;18(12):1655-1671. Epub 2023 Sep 9 doi: 10.1016/j.jtho.2023.09.002. PMID: 37689391
Okumura M, Marino M, Cilento V, Goren E, Ruffini E, Dibaba D, Ahmad U, Appel S, Bille A, Boubia S, Brambilla C, Cangir AK, Detterbeck F, Falkson C, Fang W, Filosso PL, Giaccone G, Girard N, Guerrera F, Huang J, Infante M, Kim DK, Lucchi M, Marom EM, Nicholson AG, Rami-Porta R, Rimner A, Simone CB 2nd, Asamura H; Members of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and of the Advisory Boards and Participating Institutions
J Thorac Oncol 2023 Dec;18(12):1638-1654. Epub 2023 Aug 25 doi: 10.1016/j.jtho.2023.08.024. PMID: 37634808
Gao S, Li J, Feng X, Shi S, He J
Sci Rep 2016 Apr 1;6:23804. doi: 10.1038/srep23804. PMID: 27033424Free PMC Article
Viti A, Bertolaccini L, Terzi A
Interact Cardiovasc Thorac Surg 2014 Dec;19(6):1054-8. Epub 2014 Sep 4 doi: 10.1093/icvts/ivu281. PMID: 25193970
Yamakawa Y, Masaoka A, Hashimoto T, Niwa H, Mizuno T, Fujii Y, Nakahara K
Cancer 1991 Nov 1;68(9):1984-7. doi: 10.1002/1097-0142(19911101)68:9<1984::aid-cncr2820680923>3.0.co;2-p. PMID: 1913546

Clinical prediction guides

Gao S, Li J, Feng X, Shi S, He J
Sci Rep 2016 Apr 1;6:23804. doi: 10.1038/srep23804. PMID: 27033424Free PMC Article
Das-Neves-Pereira JC, Bagan P, Milanez-de-Campos JR, Capelozzi VL, Danel C, Jatene FB, Bernaudin JF, Riquet M
Eur J Cardiothorac Surg 2008 Sep;34(3):473-7; discussion 477-8. Epub 2008 Jul 29 doi: 10.1016/j.ejcts.2008.06.008. PMID: 18667324
Fukai I, Masaoka A, Fujii Y, Yamakawa Y, Yokoyama T, Murase T, Eimoto T
Ann Thorac Surg 1999 Jan;67(1):208-11. doi: 10.1016/s0003-4975(98)01063-7. PMID: 10086551
Bajorin DF, Mazumdar M, Meyers M, Motzer RJ, Vlamis V, Lin P, Bosl GJ
J Clin Oncol 1998 Feb;16(2):707-15. doi: 10.1200/JCO.1998.16.2.707. PMID: 9469361
Yamakawa Y, Masaoka A, Hashimoto T, Niwa H, Mizuno T, Fujii Y, Nakahara K
Cancer 1991 Nov 1;68(9):1984-7. doi: 10.1002/1097-0142(19911101)68:9<1984::aid-cncr2820680923>3.0.co;2-p. PMID: 1913546

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