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RISS Stage III Plasma Cell Myeloma

MedGen UID:
1641034
•Concept ID:
C4683785
•
Neoplastic Process
Synonym: Revised International Staging System Stage IIII Plasma Cell Myeloma

Definition

Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRISS Stage III Plasma Cell Myeloma

Professional guidelines

PubMed

Real-world assessment of the treatment patterns and outcomes among patients with multiple myeloma across different risk stratification criteria in the United States: a retrospective cohort study.
Rahman M, Keegan A, Mateus J, Kim C
Leuk Lymphoma 2023 Feb;64(2):388-397. Epub 2022 Nov 12 doi: 10.1080/10428194.2022.2140283. PMID: 36371167
Comparison of clinical characteristics, treatment efficacy and survival in patients with newly diagnosed multiple myeloma with single- versus multi-site extramedullary invasion.
Zhao Y, Zhou F
J Cancer Res Clin Oncol 2023 Mar;149(3):995-1006. Epub 2022 Feb 25 doi: 10.1007/s00432-022-03948-9. PMID: 35212816
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article

Recent clinical studies

Etiology

Development and validation of an individualized and weighted Myeloma Prognostic Score System (MPSS) in patients with newly diagnosed multiple myeloma.
Mao X, Yan W, Mery D, Liu J, Fan H, Xu J, Xu Y, Sui W, Deng S, Zou D, Du C, Yi S, van Rhee F, Barlogie B, Shaughnessy JD Jr, Anderson KC, Zhan F, Qiu L, An G
Am J Hematol 2024 Apr;99(4):523-533. Epub 2024 Jan 21 doi: 10.1002/ajh.27207. PMID: 38247315Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Characteristics and clinical outcome of high-risk multiple myeloma patients in Korea (KMM 1805).
Kim K, Kim JS, Yoon SS, Yoon DH, Eom HS, Lee JJ, Yim HW, Park M, Lee H, Min CK; Korean Multiple Myeloma Working Party (KMMWP)
Int J Hematol 2022 Jul;116(1):110-121. Epub 2022 May 11 doi: 10.1007/s12185-022-03332-w. PMID: 35543899
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution.
Zhong L, Yang X, Zhou Y, Xiao J, Li H, Tao J, Xi Q, Chu C, Li C, Yang X, Yang C, Zhang Y, Shuai P, Liu Y, Yu M, Shi Y, Hu J, Zhang W, Gong B, Yang Z
Sci China Life Sci 2022 Sep;65(9):1811-1823. Epub 2022 Apr 7 doi: 10.1007/s11427-021-2097-1. PMID: 35437648
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Diagnosis

Development and validation of an individualized and weighted Myeloma Prognostic Score System (MPSS) in patients with newly diagnosed multiple myeloma.
Mao X, Yan W, Mery D, Liu J, Fan H, Xu J, Xu Y, Sui W, Deng S, Zou D, Du C, Yi S, van Rhee F, Barlogie B, Shaughnessy JD Jr, Anderson KC, Zhan F, Qiu L, An G
Am J Hematol 2024 Apr;99(4):523-533. Epub 2024 Jan 21 doi: 10.1002/ajh.27207. PMID: 38247315Free PMC Article
A real-world data analysis of predictors of early mortality after a diagnosis of multiple myeloma.
Grant SJ, Wildes TM, Rosko AE, Silberstein J, Giri S
Cancer 2023 Jul 1;129(13):2023-2034. Epub 2023 Mar 29 doi: 10.1002/cncr.34760. PMID: 36989073Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Therapy

Real-life experiences with CAR T-cell therapy with idecabtagene vicleucel (ide-cel) for triple-class exposed relapsed/refractory multiple myeloma patients.
Sanoyan DA, Seipel K, Bacher U, Kronig MN, Porret N, Wiedemann G, Daskalakis M, Pabst T
BMC Cancer 2023 Apr 15;23(1):345. doi: 10.1186/s12885-023-10824-3. PMID: 37061680Free PMC Article
Isatuximab Plus Carfilzomib and Dexamethasone Versus Carfilzomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: IKEMA Subgroup Analysis by Prior Transplantation.
Martin TG, Capra M, Mohty M, Suzuki K, Quach H, Cavo M, Moreau P, Dimopoulos M, Yong K, Tekle C, Foster MC, Barnes Y, Risse ML, Mikhael J
Transplant Cell Ther 2023 Feb;29(2):134.e1-134.e7. Epub 2022 Nov 11 doi: 10.1016/j.jtct.2022.11.005. PMID: 36372355
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Prognostic and predictive performance of R-ISS with SKY92 in older patients with multiple myeloma: the HOVON-87/NMSG-18 trial.
Kuiper R, Zweegman S, van Duin M, van Vliet MH, van Beers EH, Dumee B, Vermeulen M, Koenders J, van der Holt B, Visser-Wisselaar H, Hansson M, van der Velden AWG, Beverloo HB, Stevens-Kroef M, Levin MD, Broijl A, Waage A, Sonneveld P
Blood Adv 2020 Dec 22;4(24):6298-6309. doi: 10.1182/bloodadvances.2020002838. PMID: 33351127Free PMC Article
Enhancing the R-ISS classification of newly diagnosed multiple myeloma by quantifying circulating clonal plasma cells.
Gonsalves WI, Jevremovic D, Nandakumar B, Dispenzieri A, Buadi FK, Dingli D, Lacy MQ, Hayman SR, Kapoor P, Leung N, Fonder A, Hobbs M, Hwa YL, Muchtar E, Warsame R, Kourelis TV, Russell S, Lust JA, Lin Y, Go RS, Siddiqui MA, Kyle RA, Gertz MA, Rajkumar SV, Kumar SK
Am J Hematol 2020 Mar;95(3):310-315. Epub 2020 Jan 8 doi: 10.1002/ajh.25709. PMID: 31867775Free PMC Article

Prognosis

Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis.
Bao L, Wang YT, Lu MQ, Chu B, Shi L, Gao S, Fang LJ, Xiang QQ, Ding YH, Liu X, Zhao X, Wang MZ, Chen Y, Hu WK
Front Endocrinol (Lausanne) 2023;14:1157969. Epub 2023 Apr 27 doi: 10.3389/fendo.2023.1157969. PMID: 37181039Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution.
Zhong L, Yang X, Zhou Y, Xiao J, Li H, Tao J, Xi Q, Chu C, Li C, Yang X, Yang C, Zhang Y, Shuai P, Liu Y, Yu M, Shi Y, Hu J, Zhang W, Gong B, Yang Z
Sci China Life Sci 2022 Sep;65(9):1811-1823. Epub 2022 Apr 7 doi: 10.1007/s11427-021-2097-1. PMID: 35437648
Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.
Chen L, Fan F, Deng J, Xu J, Xu A, Sun C, Hu Y
Ann Hematol 2019 Apr;98(4):963-970. Epub 2019 Jan 4 doi: 10.1007/s00277-018-3582-4. PMID: 30610280
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Clinical prediction guides

Development and validation of an individualized and weighted Myeloma Prognostic Score System (MPSS) in patients with newly diagnosed multiple myeloma.
Mao X, Yan W, Mery D, Liu J, Fan H, Xu J, Xu Y, Sui W, Deng S, Zou D, Du C, Yi S, van Rhee F, Barlogie B, Shaughnessy JD Jr, Anderson KC, Zhan F, Qiu L, An G
Am J Hematol 2024 Apr;99(4):523-533. Epub 2024 Jan 21 doi: 10.1002/ajh.27207. PMID: 38247315Free PMC Article
A real-world data analysis of predictors of early mortality after a diagnosis of multiple myeloma.
Grant SJ, Wildes TM, Rosko AE, Silberstein J, Giri S
Cancer 2023 Jul 1;129(13):2023-2034. Epub 2023 Mar 29 doi: 10.1002/cncr.34760. PMID: 36989073Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma.
Zhang B, Bian B, Zhao Z, Lin F, Zhu Z, Lou M
BMC Med Imaging 2021 Jun 8;21(1):98. doi: 10.1186/s12880-021-00631-2. PMID: 34103001Free PMC Article
Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.
Chen L, Fan F, Deng J, Xu J, Xu A, Sun C, Hu Y
Ann Hematol 2019 Apr;98(4):963-970. Epub 2019 Jan 4 doi: 10.1007/s00277-018-3582-4. PMID: 30610280

Recent systematic reviews

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.
Li Q, Ai L, Zuo L, Li J, Zhao F, Xu A, Zhang B, Cai L, Hu Y, Sun C
Ann Med 2024 Dec;56(1):2338604. Epub 2024 Apr 10 doi: 10.1080/07853890.2024.2338604. PMID: 38599340Free PMC Article

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