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Lyme Disease, Chronic

MedGen UID:
1641487
•Concept ID:
C2063079
•
Disease or Syndrome
Synonyms: Chronic Lyme Disease; Post Lyme Disease Syndrome; Post-Lyme Disease Syndrome; Post-Lyme Disease Syndromes; Syndrome, Post-Lyme Disease; Syndromes, Post-Lyme Disease

Definition

A condition caused by long-lasting and ongoing infection with the spirochete Borrelia burgdorferi resulting in progressive inflammatory neurologic, neuromuscular, and dermatologic manifestations including ENCEPHALITIS; MYELITIS; acrodermatitis chronica atrophicans; and ARTHRITIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLyme Disease, Chronic

Professional guidelines

PubMed

Persistent Symptoms After Treatment of Lyme Disease.
Marques A
Infect Dis Clin North Am 2022 Sep;36(3):621-638. doi: 10.1016/j.idc.2022.04.004. PMID: 36116839Free PMC Article
A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist.
Wong KH, Shapiro ED, Soffer GK
Clin Rev Allergy Immunol 2022 Feb;62(1):264-271. Epub 2021 Oct 23 doi: 10.1007/s12016-021-08906-w. PMID: 34687445
Lyme neuroborreliosis-epidemiology, diagnosis and management.
Koedel U, Fingerle V, Pfister HW
Nat Rev Neurol 2015 Aug;11(8):446-56. Epub 2015 Jul 28 doi: 10.1038/nrneurol.2015.121. PMID: 26215621

Recent clinical studies

Etiology

Muscle, reticuloendothelial, and late skin manifestations of Lyme disease.
Ilowite NT
Am J Med 1995 Apr 24;98(4A):63S-68S. doi: 10.1016/s0002-9343(99)80046-1. PMID: 7726194

Diagnosis

A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist.
Wong KH, Shapiro ED, Soffer GK
Clin Rev Allergy Immunol 2022 Feb;62(1):264-271. Epub 2021 Oct 23 doi: 10.1007/s12016-021-08906-w. PMID: 34687445
Nervous system Lyme disease, chronic Lyme disease, and none of the above.
Halperin JJ
Acta Neurol Belg 2016 Mar;116(1):1-6. Epub 2015 Sep 16 doi: 10.1007/s13760-015-0541-x. PMID: 26377699
Implications of gender in chronic Lyme disease.
Wormser GP, Shapiro ED
J Womens Health (Larchmt) 2009 Jun;18(6):831-4. doi: 10.1089/jwh.2008.1193. PMID: 19514824Free PMC Article
Dispelling the chronic Lyme disease myth.
Kemperman MM, Bakken JS, Kravitz GR
Minn Med 2008 Jul;91(7):37-41. PMID: 18714930

Therapy

Nervous system Lyme disease, chronic Lyme disease, and none of the above.
Halperin JJ
Acta Neurol Belg 2016 Mar;116(1):1-6. Epub 2015 Sep 16 doi: 10.1007/s13760-015-0541-x. PMID: 26377699
Implications of gender in chronic Lyme disease.
Wormser GP, Shapiro ED
J Womens Health (Larchmt) 2009 Jun;18(6):831-4. doi: 10.1089/jwh.2008.1193. PMID: 19514824Free PMC Article
Dispelling the chronic Lyme disease myth.
Kemperman MM, Bakken JS, Kravitz GR
Minn Med 2008 Jul;91(7):37-41. PMID: 18714930

Prognosis

Nervous system Lyme disease, chronic Lyme disease, and none of the above.
Halperin JJ
Acta Neurol Belg 2016 Mar;116(1):1-6. Epub 2015 Sep 16 doi: 10.1007/s13760-015-0541-x. PMID: 26377699

Clinical prediction guides

Muscle, reticuloendothelial, and late skin manifestations of Lyme disease.
Ilowite NT
Am J Med 1995 Apr 24;98(4A):63S-68S. doi: 10.1016/s0002-9343(99)80046-1. PMID: 7726194

Supplemental Content

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