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Opioid-induced constipation

MedGen UID:
1641995
Concept ID:
C3160897
Sign or Symptom
Synonyms: Constipation, Opiate-Induced; Constipation, Opioid-Induced; Opiate Induced Constipation; Opiate-Induced Constipation; Opiate-Induced Constipations; Opioid Induced Constipation; Opioid-Induced Constipation; Opioid-Induced Constipations
 
Monarch Initiative: MONDO:0100187

Definition

Constipation that results from, or follows, treatment with an opioid or opioid-containing medication. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOpioid-induced constipation

Professional guidelines

PubMed

Bharucha AE, Lacy BE
Gastroenterology 2020 Apr;158(5):1232-1249.e3. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2019.12.034. PMID: 31945360Free PMC Article
Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M
Expert Rev Gastroenterol Hepatol 2020 Jan;14(1):39-46. Epub 2020 Jan 2 doi: 10.1080/17474124.2020.1708718. PMID: 31893959
Prichard D, Norton C, Bharucha AE
Br J Nurs 2016 May 26-Jun 8;25(10):S4-5, S8-11. doi: 10.12968/bjon.2016.25.10.S4. PMID: 27231750

Recent clinical studies

Etiology

De Giorgio R, Zucco FM, Chiarioni G, Mercadante S, Corazziari ES, Caraceni A, Odetti P, Giusti R, Marinangeli F, Pinto C
Adv Ther 2021 Jul;38(7):3589-3621. Epub 2021 Jun 4 doi: 10.1007/s12325-021-01766-y. PMID: 34086265Free PMC Article
Deb B, Prichard DO, Bharucha AE
Curr Gastroenterol Rep 2020 Aug 24;22(11):54. doi: 10.1007/s11894-020-00791-1. PMID: 32839874
Serra J, Pohl D, Azpiroz F, Chiarioni G, Ducrotté P, Gourcerol G, Hungin APS, Layer P, Mendive JM, Pfeifer J, Rogler G, Scott SM, Simrén M, Whorwell P; Functional Constipation Guidelines Working Group
Neurogastroenterol Motil 2020 Feb;32(2):e13762. Epub 2019 Nov 22 doi: 10.1111/nmo.13762. PMID: 31756783
Bharucha AE, Wald A
Mayo Clin Proc 2019 Nov;94(11):2340-2357. Epub 2019 May 1 doi: 10.1016/j.mayocp.2019.01.031. PMID: 31054770Free PMC Article
Rao SS, Rattanakovit K, Patcharatrakul T
Nat Rev Gastroenterol Hepatol 2016 May;13(5):295-305. Epub 2016 Apr 1 doi: 10.1038/nrgastro.2016.53. PMID: 27033126

Diagnosis

Deb B, Prichard DO, Bharucha AE
Curr Gastroenterol Rep 2020 Aug 24;22(11):54. doi: 10.1007/s11894-020-00791-1. PMID: 32839874
Bharucha AE, Lacy BE
Gastroenterology 2020 Apr;158(5):1232-1249.e3. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2019.12.034. PMID: 31945360Free PMC Article
Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M
Expert Rev Gastroenterol Hepatol 2020 Jan;14(1):39-46. Epub 2020 Jan 2 doi: 10.1080/17474124.2020.1708718. PMID: 31893959
Bharucha AE, Wald A
Mayo Clin Proc 2019 Nov;94(11):2340-2357. Epub 2019 May 1 doi: 10.1016/j.mayocp.2019.01.031. PMID: 31054770Free PMC Article
Farmer AD, Holt CB, Downes TJ, Ruggeri E, Del Vecchio S, De Giorgio R
Lancet Gastroenterol Hepatol 2018 Mar;3(3):203-212. doi: 10.1016/S2468-1253(18)30008-6. PMID: 29870734

Therapy

Bharucha AE, Lacy BE
Gastroenterology 2020 Apr;158(5):1232-1249.e3. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2019.12.034. PMID: 31945360Free PMC Article
Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M
Expert Rev Gastroenterol Hepatol 2020 Jan;14(1):39-46. Epub 2020 Jan 2 doi: 10.1080/17474124.2020.1708718. PMID: 31893959
Bharucha AE, Wald A
Mayo Clin Proc 2019 Nov;94(11):2340-2357. Epub 2019 May 1 doi: 10.1016/j.mayocp.2019.01.031. PMID: 31054770Free PMC Article
Müller-Lissner S, Bassotti G, Coffin B, Drewes AM, Breivik H, Eisenberg E, Emmanuel A, Laroche F, Meissner W, Morlion B
Pain Med 2017 Oct 1;18(10):1837-1863. doi: 10.1093/pm/pnw255. PMID: 28034973Free PMC Article
Prichard D, Norton C, Bharucha AE
Br J Nurs 2016 May 26-Jun 8;25(10):S4-5, S8-11. doi: 10.12968/bjon.2016.25.10.S4. PMID: 27231750

Prognosis

Habeeb EA, Tran LK, Goodberlet MZ, Lupi KE, DeGrado JR, Dube KM
Ann Pharmacother 2023 Jul;57(7):762-768. Epub 2022 Oct 29 doi: 10.1177/10600280221132851. PMID: 36314271
Engle AL, Winans ARM
J Pain Palliat Care Pharmacother 2021 Mar;35(1):63-72. Epub 2021 Feb 17 doi: 10.1080/15360288.2020.1828529. PMID: 33596159
Olson EA, Metzger AK, Mallory MJ, Mackey RM
J Pain Symptom Manage 2021 Oct;62(4):876-880. Epub 2021 Feb 5 doi: 10.1016/j.jpainsymman.2021.01.135. PMID: 33556492
Samolsky Dekel BG, Sorella MC, Vasarri A, Gori A, Melotti RM
J Opioid Manag 2019 Sep/Oct;15(5):375-387. doi: 10.5055/jom.2019.0527. PMID: 31849029
Drugs R D 2006;7(6):374-8. doi: 10.2165/00126839-200607060-00006. PMID: 17073520

Clinical prediction guides

Engle AL, Winans ARM
J Pain Palliat Care Pharmacother 2021 Mar;35(1):63-72. Epub 2021 Feb 17 doi: 10.1080/15360288.2020.1828529. PMID: 33596159
Song X, Wang D, Qu X, Dong N, Teng S
Expert Rev Clin Pharmacol 2019 Feb;12(2):121-128. Epub 2019 Jan 24 doi: 10.1080/17512433.2019.1570845. PMID: 30652502
Nusrat S, Syed T, Saleem R, Clifton S, Bielefeldt K
Dig Dis Sci 2019 Jan;64(1):39-49. Epub 2018 Oct 3 doi: 10.1007/s10620-018-5308-9. PMID: 30284134
Wald A
JAMA 2016 Jan 12;315(2):185-91. doi: 10.1001/jama.2015.16994. PMID: 26757467
Garnock-Jones KP, McKeage K
Drugs 2010 May 7;70(7):919-28. doi: 10.2165/11204520-000000000-00000. PMID: 20426500

Recent systematic reviews

Kistemaker KRJ, Sijani F, Brinkman DJ, de Graeff A, Burchell GL, Steegers MAH, van Zuylen L
Cancer Treat Rev 2024 Apr;125:102704. Epub 2024 Mar 1 doi: 10.1016/j.ctrv.2024.102704. PMID: 38452708
Candy B, Jones L, Vickerstaff V, Larkin PJ, Stone P
Cochrane Database Syst Rev 2022 Sep 15;9(9):CD006332. doi: 10.1002/14651858.CD006332.pub4. PMID: 36106667Free PMC Article
Nee J, Zakari M, Sugarman MA, Whelan J, Hirsch W, Sultan S, Ballou S, Iturrino J, Lembo A
Clin Gastroenterol Hepatol 2018 Oct;16(10):1569-1584.e2. Epub 2018 Jan 31 doi: 10.1016/j.cgh.2018.01.021. PMID: 29374616
Schwenk ES, Grant AE, Torjman MC, McNulty SE, Baratta JL, Viscusi ER
Reg Anesth Pain Med 2017 Nov/Dec;42(6):767-777. doi: 10.1097/AAP.0000000000000671. PMID: 29016552
Siemens W, Gaertner J, Becker G
Expert Opin Pharmacother 2015 Mar;16(4):515-32. Epub 2014 Dec 24 doi: 10.1517/14656566.2015.995625. PMID: 25539282

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