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Decreased waist to hip ratio

MedGen UID:
1643227
•Concept ID:
C4703555
•
Finding
Synonyms: Decreased waist-hip ratio; Decreased waist-to-hip ratio; Decreased WHR
 
HPO: HP:0031820

Definition

Decreased waist-to-hip ratio (WHR) is a measurement below the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased waist to hip ratio

Professional guidelines

PubMed

Back to the Future: Is GnRHa Treatment in Transgender and Gender Diverse Adolescents Only an Extended Evaluation Phase?
Fisher AD, Ristori J, Romani A, Cassioli E, Mazzoli F, Cocchetti C, Pierdominici M, Marconi M, Ricca V, Maggi M, Vignozzi L, Castellini G
J Clin Endocrinol Metab 2024 May 17;109(6):1565-1579. doi: 10.1210/clinem/dgad729. PMID: 38099569
An EASO position statement on multidisciplinary obesity management in adults.
Yumuk V, Frühbeck G, Oppert JM, Woodward E, Toplak H
Obes Facts 2014;7(2):96-101. Epub 2014 Mar 26 doi: 10.1159/000362191. PMID: 24685592Free PMC Article
Medical evaluation and treatment of the obese patient with cardiovascular disease.
Blackburn GL, Kanders BS
Am J Cardiol 1987 Oct 30;60(12):55G-58G. doi: 10.1016/0002-9149(87)90592-3. PMID: 3314451

Recent clinical studies

Etiology

Trajectories of Waist-to-Hip Ratio and Adverse Outcomes in Heart Failure with Mid-Range Ejection Fraction.
Gao F, Wan J, Xu B, Wang X, Lin X, Wang P
Obes Facts 2020;13(3):344-357. Epub 2020 Jun 22 doi: 10.1159/000507708. PMID: 32570251Free PMC Article
Decrease in waist-to-hip ratio reduced the development of chronic kidney disease in non-obese non-alcoholic fatty liver disease.
Chon YE, Kim HJ, Choi YB, Hwang SG, Rim KS, Kim MN, Lee JH, Ha Y, Lee MJ
Sci Rep 2020 Jun 2;10(1):8996. doi: 10.1038/s41598-020-65940-y. PMID: 32488147Free PMC Article
Fat mass changes during menopause: a metaanalysis.
Ambikairajah A, Walsh E, Tabatabaei-Jafari H, Cherbuin N
Am J Obstet Gynecol 2019 Nov;221(5):393-409.e50. Epub 2019 Apr 26 doi: 10.1016/j.ajog.2019.04.023. PMID: 31034807
The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial.
Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM
BMC Complement Altern Med 2016 Nov 16;16(1):471. doi: 10.1186/s12906-016-1432-2. PMID: 27852303Free PMC Article
The metabolic syndrome.
Fernandez ML
Nutr Rev 2007 Jun;65(6 Pt 2):S30-4. doi: 10.1111/j.1753-4887.2007.tb00325.x. PMID: 17605311

Diagnosis

Mendelian randomization analyses identify bidirectional causal relationships of obesity with psychiatric disorders.
Chen W, Feng J, Jiang S, Guo J, Zhang X, Zhang X, Wang C, Ma Y, Dong Z
J Affect Disord 2023 Oct 15;339:807-814. Epub 2023 Jul 19 doi: 10.1016/j.jad.2023.07.044. PMID: 37474010
Polycystic ovary syndrome and adipose tissue.
Lemaitre M, Christin-Maitre S, Kerlan V
Ann Endocrinol (Paris) 2023 Apr;84(2):308-315. Epub 2023 Jan 7 doi: 10.1016/j.ando.2022.11.004. PMID: 36623807
Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study.
Wang Y, Ye C, Kong L, Zheng J, Xu M, Xu Y, Li M, Zhao Z, Lu J, Chen Y, Wang W, Ning G, Bi Y, Wang T
Hypertension 2023 Jan;80(1):192-203. Epub 2022 Nov 10 doi: 10.1161/HYPERTENSIONAHA.122.20286. PMID: 36353998Free PMC Article
Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.
Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C
Clin Chem 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334Free PMC Article
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women.
Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH
Nutr Res 2015 May;35(5):409-20. Epub 2015 Apr 10 doi: 10.1016/j.nutres.2015.04.001. PMID: 25912765

Therapy

Mendelian randomization analyses identify bidirectional causal relationships of obesity with psychiatric disorders.
Chen W, Feng J, Jiang S, Guo J, Zhang X, Zhang X, Wang C, Ma Y, Dong Z
J Affect Disord 2023 Oct 15;339:807-814. Epub 2023 Jul 19 doi: 10.1016/j.jad.2023.07.044. PMID: 37474010
Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.
Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C
Clin Chem 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334Free PMC Article
The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials.
Maharlouei N, Tabrizi R, Lankarani KB, Rezaianzadeh A, Akbari M, Kolahdooz F, Rahimi M, Keneshlou F, Asemi Z
Crit Rev Food Sci Nutr 2019;59(11):1753-1766. Epub 2018 Feb 2 doi: 10.1080/10408398.2018.1427044. PMID: 29393665
The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial.
Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM
BMC Complement Altern Med 2016 Nov 16;16(1):471. doi: 10.1186/s12906-016-1432-2. PMID: 27852303Free PMC Article
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women.
Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH
Nutr Res 2015 May;35(5):409-20. Epub 2015 Apr 10 doi: 10.1016/j.nutres.2015.04.001. PMID: 25912765

Prognosis

Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study.
Wang Y, Ye C, Kong L, Zheng J, Xu M, Xu Y, Li M, Zhao Z, Lu J, Chen Y, Wang W, Ning G, Bi Y, Wang T
Hypertension 2023 Jan;80(1):192-203. Epub 2022 Nov 10 doi: 10.1161/HYPERTENSIONAHA.122.20286. PMID: 36353998Free PMC Article
Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.
Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C
Clin Chem 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334Free PMC Article
Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Kim J, Yun JM, Kim MK, Kwon O, Cho B
J Med Food 2018 May;21(5):454-461. Epub 2018 Apr 24 doi: 10.1089/jmf.2017.3937. PMID: 29688793
The Global Epidemic of the Metabolic Syndrome.
Saklayen MG
Curr Hypertens Rep 2018 Feb 26;20(2):12. doi: 10.1007/s11906-018-0812-z. PMID: 29480368Free PMC Article
Diabetes in Vietnam.
Khue NT
Ann Glob Health 2015 Nov-Dec;81(6):870-3. doi: 10.1016/j.aogh.2016.01.003. PMID: 27108154

Clinical prediction guides

Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.
Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C
Clin Chem 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334Free PMC Article
Trajectories of Waist-to-Hip Ratio and Adverse Outcomes in Heart Failure with Mid-Range Ejection Fraction.
Gao F, Wan J, Xu B, Wang X, Lin X, Wang P
Obes Facts 2020;13(3):344-357. Epub 2020 Jun 22 doi: 10.1159/000507708. PMID: 32570251Free PMC Article
Fat mass changes during menopause: a metaanalysis.
Ambikairajah A, Walsh E, Tabatabaei-Jafari H, Cherbuin N
Am J Obstet Gynecol 2019 Nov;221(5):393-409.e50. Epub 2019 Apr 26 doi: 10.1016/j.ajog.2019.04.023. PMID: 31034807
The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial.
Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM
BMC Complement Altern Med 2016 Nov 16;16(1):471. doi: 10.1186/s12906-016-1432-2. PMID: 27852303Free PMC Article
Diabetes in Vietnam.
Khue NT
Ann Glob Health 2015 Nov-Dec;81(6):870-3. doi: 10.1016/j.aogh.2016.01.003. PMID: 27108154

Recent systematic reviews

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Coconut oil consumption and bodyweight reduction: a systematic review and meta-analysis.
Swarnamali H, Ranasinghe P, Hills AP, Jayawardena R
Minerva Endocrinol (Torino) 2023 Mar;48(1):76-87. Epub 2021 Nov 17 doi: 10.23736/S2724-6507.21.03654-X. PMID: 34786908
Additive stress of normobaric hypoxic conditioning to improve body mass loss and cardiometabolic markers in individuals with overweight or obesity: A systematic review and meta-analysis.
Ramos-Campo DJ, Girard O, Pérez A, Rubio-Arias JÁ
Physiol Behav 2019 Aug 1;207:28-40. Epub 2019 Apr 30 doi: 10.1016/j.physbeh.2019.04.027. PMID: 31047948
The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials.
Maharlouei N, Tabrizi R, Lankarani KB, Rezaianzadeh A, Akbari M, Kolahdooz F, Rahimi M, Keneshlou F, Asemi Z
Crit Rev Food Sci Nutr 2019;59(11):1753-1766. Epub 2018 Feb 2 doi: 10.1080/10408398.2018.1427044. PMID: 29393665
Phytoestrogen supplementation and body composition in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.
Glisic M, Kastrati N, Musa J, Milic J, Asllanaj E, Portilla Fernandez E, Nano J, Ochoa Rosales C, Amiri M, Kraja B, Bano A, Bramer WM, Roks AJM, Danser AHJ, Franco OH, Muka T
Maturitas 2018 Sep;115:74-83. Epub 2018 Jun 22 doi: 10.1016/j.maturitas.2018.06.012. PMID: 30049351

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