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Refractory Extensive Stage Lung Small Cell Carcinoma

MedGen UID:
1643507
•Concept ID:
C4683499
•
Neoplastic Process
Synonym: Refractory Extensive Stage Small Cell Lung Carcinoma

Definition

Extensive stage small cell lung carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Extensive Stage Lung Small Cell Carcinoma

Professional guidelines

PubMed

Extensive-stage small-cell lung cancer: Current management and future directions.
Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Management of small-cell lung cancer: incremental changes but hope for the future.
Hann CL, Rudin CM
Oncology (Williston Park) 2008 Nov 30;22(13):1486-92. PMID: 19133604Free PMC Article
Treatment of small cell lung cancer.
Kurup A, Hanna NH
Crit Rev Oncol Hematol 2004 Nov;52(2):117-26. doi: 10.1016/j.critrevonc.2004.08.005. PMID: 15501076

Recent clinical studies

Etiology

Reconsidering the Cutoff Value for Sensitive and Refractory Relapses in Extensive-Stage SCLC in the Era of Immunotherapy.
Torasawa M, Horinouchi H, Nomura S, Igawa S, Asai M, Ishii H, Wakui H, Ushio R, Asao T, Namba Y, Koyama R, Hayakawa D, Katayama I, Matsuda H, Sasaki S, Takahashi K, Hosomi Y, Naoki K, Ohe Y
J Thorac Oncol 2024 Feb;19(2):325-336. Epub 2023 Sep 23 doi: 10.1016/j.jtho.2023.09.1446. PMID: 37748690
Treatment patterns and outcomes among patients with small-cell lung cancer (SCLC) in Europe: a retrospective cohort study.
Blackhall F, Girard N, Livartowski A, McDonald L, Roset M, Lara N, Juarez García A
BMJ Open 2023 Feb 6;13(2):e052556. doi: 10.1136/bmjopen-2021-052556. PMID: 36746549Free PMC Article
Real-world efficacy and safety of anlotinib as third- or further-line treatment in refractory small cell lung cancer.
Gao X, Peng L, Zhang L, Huang K, Yi C, Li B, Meng X, Li J
J Cancer Res Clin Oncol 2022 Oct;148(10):2661-2671. Epub 2021 Nov 8 doi: 10.1007/s00432-021-03848-4. PMID: 34748028
Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study.
Morgensztern D, Besse B, Greillier L, Santana-Davila R, Ready N, Hann CL, Glisson BS, Farago AF, Dowlati A, Rudin CM, Le Moulec S, Lally S, Yalamanchili S, Wolf J, Govindan R, Carbone DP
Clin Cancer Res 2019 Dec 1;25(23):6958-6966. Epub 2019 Sep 10 doi: 10.1158/1078-0432.CCR-19-1133. PMID: 31506387Free PMC Article
Apatinib for chemotherapy-refractory extensive-stage SCLC: a retrospective study.
Li H, Zeng J, Jin X, Yu X, Zhou G, Hong W
Cancer Chemother Pharmacol 2019 Jun;83(6):1083-1090. Epub 2019 Apr 1 doi: 10.1007/s00280-019-03823-4. PMID: 30937519

Diagnosis

Reconsidering the Cutoff Value for Sensitive and Refractory Relapses in Extensive-Stage SCLC in the Era of Immunotherapy.
Torasawa M, Horinouchi H, Nomura S, Igawa S, Asai M, Ishii H, Wakui H, Ushio R, Asao T, Namba Y, Koyama R, Hayakawa D, Katayama I, Matsuda H, Sasaki S, Takahashi K, Hosomi Y, Naoki K, Ohe Y
J Thorac Oncol 2024 Feb;19(2):325-336. Epub 2023 Sep 23 doi: 10.1016/j.jtho.2023.09.1446. PMID: 37748690
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Clinical correlation of extensive-stage small-cell lung cancer genomics.
Dowlati A, Lipka MB, McColl K, Dabir S, Behtaj M, Kresak A, Miron A, Yang M, Sharma N, Fu P, Wildey G
Ann Oncol 2016 Apr;27(4):642-7. Epub 2016 Jan 22 doi: 10.1093/annonc/mdw005. PMID: 26802149Free PMC Article
Chemotherapy for advanced stage non-small cell lung cancer.
Fathi AT, Brahmer JR
Semin Thorac Cardiovasc Surg 2008 Fall;20(3):210-6. doi: 10.1053/j.semtcvs.2008.09.002. PMID: 19038730
Treatment of small cell lung cancer.
Kurup A, Hanna NH
Crit Rev Oncol Hematol 2004 Nov;52(2):117-26. doi: 10.1016/j.critrevonc.2004.08.005. PMID: 15501076

Therapy

Extensive-stage small-cell lung cancer: Current management and future directions.
Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study.
Morgensztern D, Besse B, Greillier L, Santana-Davila R, Ready N, Hann CL, Glisson BS, Farago AF, Dowlati A, Rudin CM, Le Moulec S, Lally S, Yalamanchili S, Wolf J, Govindan R, Carbone DP
Clin Cancer Res 2019 Dec 1;25(23):6958-6966. Epub 2019 Sep 10 doi: 10.1158/1078-0432.CCR-19-1133. PMID: 31506387Free PMC Article
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Chemotherapy for advanced stage non-small cell lung cancer.
Fathi AT, Brahmer JR
Semin Thorac Cardiovasc Surg 2008 Fall;20(3):210-6. doi: 10.1053/j.semtcvs.2008.09.002. PMID: 19038730
Small cell lung cancer.
Simon GR, Wagner H; American College of Chest Physicians
Chest 2003 Jan;123(1 Suppl):259S-271S. doi: 10.1378/chest.123.1_suppl.259s. PMID: 12527584

Prognosis

Current Strategies for Extensive Stage Small Cell Lung Cancer Beyond First-line Therapy.
Hao Z, Sekkath Veedu J
Clin Lung Cancer 2022 Jan;23(1):14-20. Epub 2021 Sep 17 doi: 10.1016/j.cllc.2021.09.003. PMID: 34656433
Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study.
Morgensztern D, Besse B, Greillier L, Santana-Davila R, Ready N, Hann CL, Glisson BS, Farago AF, Dowlati A, Rudin CM, Le Moulec S, Lally S, Yalamanchili S, Wolf J, Govindan R, Carbone DP
Clin Cancer Res 2019 Dec 1;25(23):6958-6966. Epub 2019 Sep 10 doi: 10.1158/1078-0432.CCR-19-1133. PMID: 31506387Free PMC Article
Chemotherapy for advanced stage non-small cell lung cancer.
Fathi AT, Brahmer JR
Semin Thorac Cardiovasc Surg 2008 Fall;20(3):210-6. doi: 10.1053/j.semtcvs.2008.09.002. PMID: 19038730
Treatment of small cell lung cancer.
Kurup A, Hanna NH
Crit Rev Oncol Hematol 2004 Nov;52(2):117-26. doi: 10.1016/j.critrevonc.2004.08.005. PMID: 15501076
Small cell lung cancer.
Simon GR, Wagner H; American College of Chest Physicians
Chest 2003 Jan;123(1 Suppl):259S-271S. doi: 10.1378/chest.123.1_suppl.259s. PMID: 12527584

Clinical prediction guides

Reconsidering the Cutoff Value for Sensitive and Refractory Relapses in Extensive-Stage SCLC in the Era of Immunotherapy.
Torasawa M, Horinouchi H, Nomura S, Igawa S, Asai M, Ishii H, Wakui H, Ushio R, Asao T, Namba Y, Koyama R, Hayakawa D, Katayama I, Matsuda H, Sasaki S, Takahashi K, Hosomi Y, Naoki K, Ohe Y
J Thorac Oncol 2024 Feb;19(2):325-336. Epub 2023 Sep 23 doi: 10.1016/j.jtho.2023.09.1446. PMID: 37748690
Efficacy and Safety of PD-1/PD-L1 Inhibitor Chemotherapy Combined with Lung Cancer Fang No. 1 in Relapsed and Refractory SCLC: A Retrospective Observational Study.
Wang L, Lei X, Wang X
Comput Math Methods Med 2022;2022:2848220. Epub 2022 May 9 doi: 10.1155/2022/2848220. PMID: 35586668Free PMC Article
Real-world efficacy and safety of anlotinib as third- or further-line treatment in refractory small cell lung cancer.
Gao X, Peng L, Zhang L, Huang K, Yi C, Li B, Meng X, Li J
J Cancer Res Clin Oncol 2022 Oct;148(10):2661-2671. Epub 2021 Nov 8 doi: 10.1007/s00432-021-03848-4. PMID: 34748028
Circulating tumor cell counts/change for outcome prediction in patients with extensive-stage small-cell lung cancer.
Cheng Y, Liu XQ, Fan Y, Liu YP, Liu Y, Liu Y, Ma LX, Liu XH, Li H, Bao HZ, Liu JJ, Zhang S, Wu CJ
Future Oncol 2016 Mar;12(6):789-99. Epub 2016 Feb 3 doi: 10.2217/fon.15.346. PMID: 26838372
Clinical correlation of extensive-stage small-cell lung cancer genomics.
Dowlati A, Lipka MB, McColl K, Dabir S, Behtaj M, Kresak A, Miron A, Yang M, Sharma N, Fu P, Wildey G
Ann Oncol 2016 Apr;27(4):642-7. Epub 2016 Jan 22 doi: 10.1093/annonc/mdw005. PMID: 26802149Free PMC Article

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